SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jjx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  64
ILE A  62
THR A  60
VAL A  84
LEU A  91
 None
 0.99A 2jn3A-1jjxA:
16.9		 2jn3A-1jjxA:
35.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN
(Homo
sapiens) 		6 / 12 PHE A  16
VAL A  25
SER A  55
ALA A  75
ARG A  78
TYR A 128
 None
 1.24A 2qm9A-1jjxA:
21.9		 2qm9A-1jjxA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN
(Homo
sapiens) 		6 / 12 PHE A  16
VAL A  25
THR A  60
ALA A  75
ARG A  78
TYR A 128
 None
 1.18A 2qm9A-1jjxA:
21.9		 2qm9A-1jjxA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN
(Homo
sapiens) 		6 / 12 PHE A  16
TYR A  19
VAL A  25
SER A  55
ARG A  78
TYR A 128
 None
 1.03A 2qm9B-1jjxA:
22.5		 2qm9B-1jjxA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN
(Homo
sapiens) 		7 / 12 PHE A  16
TYR A  19
VAL A  25
THR A  60
ALA A  75
ARG A  78
TYR A 128
 None
 1.06A 2qm9B-1jjxA:
22.5		 2qm9B-1jjxA:
55.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN
(Homo
sapiens) 		4 / 7 PHE A   4
LEU A  91
LEU A  66
LEU A  86
 None
 0.93A 3bgdB-1jjxA:
undetectable		 3bgdB-1jjxA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN
(Homo
sapiens) 		4 / 7 GLU A 107
VAL A 114
THR A 116
VAL A 125
 None
 0.35A 3em0B-1jjxA:
14.9		 3em0B-1jjxA:
30.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN
(Homo
sapiens) 		6 / 12 MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
TYR A 128
 None
 1.22A 3p6gA-1jjxA:
22.0		 3p6gA-1jjxA:
56.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  16
MET A  20
VAL A  25
ARG A  78
TYR A 128
 None
 1.05A 3p6gA-1jjxA:
22.0		 3p6gA-1jjxA:
56.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN
(Homo
sapiens) 		4 / 6 TYR A  19
GLU A  72
THR A  74
GLN A  95
 None
 0.88A 4qztA-1jjxA:
18.3		 4qztA-1jjxA:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN
(Homo
sapiens) 		5 / 6 TYR A  19
GLU A  72
THR A  74
GLN A  95
LEU A 117
 None
 0.87A 4qzuC-1jjxA:
18.4		 4qzuC-1jjxA:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  16
TYR A  19
PRO A  38
ILE A  51
SER A  55
 None
 1.08A 5hbsA-1jjxA:
18.3		 5hbsA-1jjxA:
39.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  16
TYR A  19
VAL A  25
PRO A  38
ILE A  51
 None
 1.07A 5hbsA-1jjxA:
18.3		 5hbsA-1jjxA:
39.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN
(Homo
sapiens) 		4 / 5 TYR A 128
MET A 115
THR A 116
LEU A 117
 None
 1.23A 5wauJ-1jjxA:
0.0		 5wauJ-1jjxA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN
(Homo
sapiens) 		4 / 5 TYR A 128
MET A 115
THR A 116
LEU A 117
 None
 1.23A 5x1bW-1jjxA:
undetectable		 5x1bW-1jjxA:
17.78