SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jk0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2
(Saccharomyces
cerevisiae) 		5 / 8 THR B 224
GLY B 221
GLY B 288
LEU B 285
GLY B 284
 None
 1.48A 1jhqA-1jk0B:
undetectable		 1jhqA-1jk0B:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2
(Saccharomyces
cerevisiae) 		5 / 8 THR B 224
GLY B 221
GLY B 288
LEU B 285
GLY B 284
 None
 1.49A 1jhvA-1jk0B:
undetectable		 1jhvA-1jk0B:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU B  85
ASN B  84
GLY B  83
LEU B 209
LEU B  74
 None
 1.45A 1nhzA-1jk0B:
undetectable		 1nhzA-1jk0B:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_A_C2FA1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2
(Saccharomyces
cerevisiae) 		5 / 11 LEU B  28
SER B 173
TYR B 175
LEU B  27
HIS B 233
 None
 1.46A 2idkA-1jk0B:
undetectable
2idkB-1jk0B:
undetectable
2idkC-1jk0B:
undetectable
2idkD-1jk0B:
undetectable		 2idkA-1jk0B:
21.13
2idkB-1jk0B:
21.13
2idkC-1jk0B:
21.13
2idkD-1jk0B:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2
(Saccharomyces
cerevisiae) 		4 / 7 ASP B  76
THR B  80
ILE B 145
ASN B 144
 None
 0.90A 2jc9A-1jk0B:
undetectable		 2jc9A-1jk0B:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2
(Saccharomyces
cerevisiae) 		4 / 7 ILE B 121
GLY B 118
LEU B 108
PHE B 182
 None
 0.99A 2vctD-1jk0B:
0.0		 2vctD-1jk0B:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2
(Saccharomyces
cerevisiae) 		4 / 6 PRO B 238
ILE B 246
ASN B 291
LEU B 286
 None
 1.38A 2wekB-1jk0B:
undetectable		 2wekB-1jk0B:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2
(Saccharomyces
cerevisiae) 		4 / 8 ASN B 110
GLU B  44
LEU B 108
PHE B 226
 None
 0.88A 3rqwC-1jk0B:
2.0
3rqwD-1jk0B:
2.2		 3rqwC-1jk0B:
19.50
3rqwD-1jk0B:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2
(Saccharomyces
cerevisiae) 		4 / 8 GLU B  44
LEU B 108
PHE B 226
ASN B 110
 None
 0.90A 3rqwF-1jk0B:
undetectable
3rqwJ-1jk0B:
undetectable		 3rqwF-1jk0B:
19.50
3rqwJ-1jk0B:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU B  27
HIS B 233
SER B 173
TYR B 175
LEU B  28
 None
 1.46A 3thrA-1jk0B:
undetectable
3thrB-1jk0B:
undetectable
3thrC-1jk0B:
undetectable
3thrD-1jk0B:
undetectable		 3thrA-1jk0B:
21.13
3thrB-1jk0B:
21.13
3thrC-1jk0B:
21.13
3thrD-1jk0B:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2
(Saccharomyces
cerevisiae) 		4 / 7 SER B 227
GLN B 120
TYR B 117
LEU B 100
 None
 1.15A 4hxyB-1jk0B:
undetectable		 4hxyB-1jk0B:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		 1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2
(Saccharomyces
cerevisiae) 		5 / 12 ALA B 232
ARG B 235
ILE B  26
ILE B  45
TYR B 117
 None
 1.23A 4qe6A-1jk0B:
0.9		 4qe6A-1jk0B:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2
(Saccharomyces
cerevisiae) 		4 / 7 LYS B 185
GLU B 186
ILE B 101
LYS B 100
 None
 1.07A 4tvtA-1jk0B:
undetectable		 4tvtA-1jk0B:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2
(Saccharomyces
cerevisiae) 		5 / 11 ASP B 219
ALA B  59
VAL B 130
TYR B 131
TYR B 127
 None
 1.27A 4xnxA-1jk0B:
1.4		 4xnxA-1jk0B:
21.61