SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jl0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens) 		5 / 8 PHE A  18
ILE A 107
PHE A 141
LEU A  94
VAL A  16
 None
 1.25A 1fslA-1jl0A:
undetectable		 1fslA-1jl0A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens) 		4 / 5 GLU A   8
GLY A  83
THR A 245
PHE A   7
 None
None
TRS  A 402 ( 4.0A)
TRS  A 402 (-3.5A)
 1.32A 1icvC-1jl0A:
0.0
1icvD-1jl0A:
0.0		 1icvC-1jl0A:
22.84
1icvD-1jl0A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens) 		5 / 12 LEU A  97
LEU A  94
LEU A  91
MET A  70
LEU A  44
 None
 1.16A 1sqnB-1jl0A:
undetectable		 1sqnB-1jl0A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens) 		3 / 3 TRP A 240
THR A 204
TYR A 228
 None
 1.27A 2a3aA-1jl0A:
undetectable		 2a3aA-1jl0A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens) 		3 / 3 ASP A 155
ILE A 179
VAL A 321
 None
 0.67A 2avvD-1jl0A:
undetectable		 2avvD-1jl0A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens) 		5 / 12 LEU A 180
ILE A 268
LEU A 177
THR A 176
LEU A 284
 None
None
None
PUT  A 401 (-3.7A)
None
 1.06A 2bdmA-1jl0A:
0.0		 2bdmA-1jl0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens) 		4 / 6 PHE A  18
LEU A  91
LEU A  97
ALA A  98
 None
 0.98A 2vcvB-1jl0A:
0.0		 2vcvB-1jl0A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens) 		3 / 3 SER A  73
GLN A  60
PHE A  71
 None
 0.82A 3g4lC-1jl0A:
0.0		 3g4lC-1jl0A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens) 		4 / 8 SER A 109
ASP A 174
TYR A 318
LEU A  13
 None
PUT  A 401 (-3.4A)
PUT  A 401 (-4.0A)
PUT  A 401 (-4.4A)
 1.04A 3jq7C-1jl0A:
undetectable		 3jq7C-1jl0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens) 		5 / 12 VAL A  64
ALA A  62
PHE A 255
VAL A 253
THR A  55
 None
 1.22A 4eckA-1jl0A:
undetectable		 4eckA-1jl0A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens) 		4 / 8 SER A 312
LEU A 177
LEU A 284
THR A 323
 None
 0.76A 4ikjA-1jl0A:
undetectable
4ikjB-1jl0A:
undetectable		 4ikjA-1jl0A:
19.41
4ikjB-1jl0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens) 		4 / 8 LEU A 177
LEU A 284
THR A 323
SER A 312
 None
 0.71A 4ikkA-1jl0A:
undetectable
4ikkB-1jl0A:
undetectable		 4ikkA-1jl0A:
19.41
4ikkB-1jl0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens) 		4 / 8 SER A 312
LEU A 177
LEU A 284
THR A 323
 None
 0.66A 4iklA-1jl0A:
undetectable
4iklB-1jl0A:
undetectable		 4iklA-1jl0A:
19.41
4iklB-1jl0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens) 		4 / 8 LEU A  79
TYR A  63
TRP A  40
LEU A  44
 None
 1.13A 4pwdC-1jl0A:
2.5		 4pwdC-1jl0A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens) 		4 / 5 PHE A 325
ARG A 269
ILE A 268
ILE A 302
 None
 1.08A 5dzk4-1jl0A:
undetectable
5dzkg-1jl0A:
undetectable
5dzkm-1jl0A:
undetectable
5dzkn-1jl0A:
undetectable		 5dzk4-1jl0A:
14.29
5dzkg-1jl0A:
18.73
5dzkm-1jl0A:
21.83
5dzkn-1jl0A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens) 		5 / 8 VAL A 271
ILE A 209
LEU A 212
ILE A 242
ILE A 244
 None
 1.44A 5numA-1jl0A:
2.8		 5numA-1jl0A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1S_B_SAMB604_0
(RADICAL SAM)		 1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens) 		5 / 9 LEU A 180
THR A 241
SER A  69
TYR A 112
SER A 113
 None
None
None
None
PUT  A 401 ( 4.3A)
 1.35A 5v1sB-1jl0A:
undetectable		 5v1sB-1jl0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens) 		3 / 3 TYR A 264
ASP A 266
GLN A 261
 None
 0.96A 6g1pA-1jl0A:
0.0		 6g1pA-1jl0A:
17.81