SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jl2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 1jl2 CHIMERA OF
RIBONUCLEASE HI,
RIBONUCLEASE H
(Thermus
thermophilus;
Escherichia
coli) 		4 / 6 GLN A   4
ASP A  66
VAL A 117
HIS A 120
 None
 1.45A 1ekjG-1jl2A:
undetectable
1ekjH-1jl2A:
undetectable		 1ekjG-1jl2A:
21.37
1ekjH-1jl2A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1jl2 CHIMERA OF
RIBONUCLEASE HI,
RIBONUCLEASE H
(Escherichia
coli;
Thermus
thermophilus) 		5 / 9 SER A  12
GLY A  21
ALA A 140
LEU A 137
GLY A  23
 None
 1.43A 1jb0A-1jl2A:
undetectable		 1jb0A-1jl2A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 1jl2 CHIMERA OF
RIBONUCLEASE HI,
RIBONUCLEASE H
(Escherichia
coli;
Thermus
thermophilus) 		5 / 12 ALA A  51
ALA A  52
LEU A  67
ALA A  24
HIS A  72
 None
 1.02A 1xiuB-1jl2A:
undetectable		 1xiuB-1jl2A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 1jl2 CHIMERA OF
RIBONUCLEASE HI,
RIBONUCLEASE H
(Escherichia
coli;
Thermus
thermophilus) 		5 / 12 VAL A  99
TRP A  91
LEU A 104
ARG A  46
MET A 112
 None
 1.48A 3h52C-1jl2A:
undetectable		 3h52C-1jl2A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1jl2 CHIMERA OF
RIBONUCLEASE HI,
RIBONUCLEASE H
(Escherichia
coli;
Thermus
thermophilus) 		5 / 9 SER A  12
GLY A  21
ALA A 140
LEU A 137
GLY A  23
 None
 1.43A 3pcqA-1jl2A:
undetectable		 3pcqA-1jl2A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1jl2 CHIMERA OF
RIBONUCLEASE HI,
RIBONUCLEASE H
(Thermus
thermophilus;
Escherichia
coli) 		3 / 3 ARG A  41
ASP A 149
ARG A  46
 None
 0.58A 4wq4B-1jl2A:
1.4		 4wq4B-1jl2A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1jl2 CHIMERA OF
RIBONUCLEASE HI,
RIBONUCLEASE H
(Escherichia
coli;
Thermus
thermophilus) 		5 / 9 SER A  12
GLY A  21
ALA A 140
LEU A 137
GLY A  23
 None
 1.44A 5l8rA-1jl2A:
undetectable		 5l8rA-1jl2A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 1jl2 CHIMERA OF
RIBONUCLEASE HI,
RIBONUCLEASE H
(Thermus
thermophilus;
Escherichia
coli) 		5 / 12 ALA A  52
GLU A   6
LEU A  26
ILE A  25
ARG A 133
 None
 1.31A 5vlmE-1jl2A:
undetectable		 5vlmE-1jl2A:
23.59