SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jl7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1jl7 MONOMER HEMOGLOBIN
COMPONENT III
(Glycera
dibranchiata) 		4 / 7 PHE A  45
PHE A  47
VAL A  62
HIS A  90
 HEM  A 148 (-3.7A)
None
HEM  A 148 ( 4.0A)
HEM  A 148 (-3.4A)
 0.72A 1lh6A-1jl7A:
13.8		 1lh6A-1jl7A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 1jl7 MONOMER HEMOGLOBIN
COMPONENT III
(Glycera
dibranchiata) 		4 / 4 ARG A 117
LEU A  63
ASN A  22
VAL A  26
 None
 1.47A 1lqtA-1jl7A:
undetectable		 1lqtA-1jl7A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 1jl7 MONOMER HEMOGLOBIN
COMPONENT III
(Glycera
dibranchiata) 		4 / 4 ARG A 117
LEU A  63
ASN A  22
VAL A  26
 None
 1.47A 1lqtB-1jl7A:
0.0		 1lqtB-1jl7A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 1jl7 MONOMER HEMOGLOBIN
COMPONENT III
(Glycera
dibranchiata) 		4 / 4 ARG A 117
LEU A  63
ASN A  22
VAL A  26
 None
 1.47A 1lquA-1jl7A:
undetectable		 1lquA-1jl7A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 1jl7 MONOMER HEMOGLOBIN
COMPONENT III
(Glycera
dibranchiata) 		4 / 4 ARG A 117
LEU A  63
ASN A  22
VAL A  26
 None
 1.46A 1lquB-1jl7A:
undetectable		 1lquB-1jl7A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 1jl7 MONOMER HEMOGLOBIN
COMPONENT III
(Glycera
dibranchiata) 		4 / 4 LYS A  61
LEU A  58
ALA A  60
LEU A  31
 None
CYN  A 149 ( 3.5A)
None
None
 1.46A 2roxA-1jl7A:
undetectable		 2roxA-1jl7A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1jl7 MONOMER HEMOGLOBIN
COMPONENT III
(Glycera
dibranchiata) 		4 / 7 LEU A   2
ALA A  11
GLY A  67
ILE A  66
 None
 0.84A 3spkB-1jl7A:
undetectable		 3spkB-1jl7A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 1jl7 MONOMER HEMOGLOBIN
COMPONENT III
(Glycera
dibranchiata) 		4 / 5 ILE A 137
ALA A 140
HIS A  72
MET A  79
 None
 1.26A 4ac9B-1jl7A:
undetectable
4ac9C-1jl7A:
undetectable		 4ac9B-1jl7A:
15.24
4ac9C-1jl7A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1jl7 MONOMER HEMOGLOBIN
COMPONENT III
(Glycera
dibranchiata) 		4 / 5 ILE A 137
ALA A 140
HIS A  72
MET A  79
 None
 1.27A 4acaB-1jl7A:
undetectable
4acaC-1jl7A:
undetectable		 4acaB-1jl7A:
15.24
4acaC-1jl7A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 1jl7 MONOMER HEMOGLOBIN
COMPONENT III
(Glycera
dibranchiata) 		5 / 12 PHE A  45
LEU A  63
LEU A 110
TYR A 134
ILE A 137
 HEM  A 148 (-3.7A)
None
None
None
None
 0.64A 4g1bD-1jl7A:
16.7		 4g1bD-1jl7A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 1jl7 MONOMER HEMOGLOBIN
COMPONENT III
(Glycera
dibranchiata) 		5 / 9 ALA A 113
SER A 138
ILE A 137
GLY A 107
VAL A  62
 None
None
None
None
HEM  A 148 ( 4.0A)
 1.12A 4r1zA-1jl7A:
1.4		 4r1zA-1jl7A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 1jl7 MONOMER HEMOGLOBIN
COMPONENT III
(Glycera
dibranchiata) 		5 / 12 ALA A  60
GLY A  59
LYS A  28
LYS A  33
LEU A 106
 None
None
None
None
HEM  A 148 ( 4.2A)
 1.07A 5nwuA-1jl7A:
undetectable		 5nwuA-1jl7A:
17.01