SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jlk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 1jlk RESPONSE REGULATOR
RCP1
(Synechocystis
sp.
PCC
6803) 		3 / 3 ASP A  16
LEU A  69
LEU A  71
 MN  A 627 ( 2.3A)
None
None
 0.69A 1ikeA-1jlkA:
0.0		 1ikeA-1jlkA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 1jlk RESPONSE REGULATOR
RCP1
(Synechocystis
sp.
PCC
6803) 		3 / 3 ASP A  16
LEU A  69
LEU A  71
 MN  A 627 ( 2.3A)
None
None
 0.76A 1np1B-1jlkA:
0.0		 1np1B-1jlkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 1jlk RESPONSE REGULATOR
RCP1
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL A  79
GLY A  76
LEU A  12
LEU A  40
ALA A  46
 None
 0.92A 2egvA-1jlkA:
3.1		 2egvA-1jlkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 1jlk RESPONSE REGULATOR
RCP1
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL A  79
GLY A  76
LEU A  12
LEU A  40
ALA A  46
 None
 0.97A 2egvB-1jlkA:
3.2		 2egvB-1jlkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 1jlk RESPONSE REGULATOR
RCP1
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A  71
ALA A  45
LEU A  12
VAL A  14
ILE A  83
 None
 0.99A 2w9gA-1jlkA:
undetectable		 2w9gA-1jlkA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 1jlk RESPONSE REGULATOR
RCP1
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A  71
ALA A  45
LEU A  12
VAL A  14
ILE A  83
 None
 1.03A 2w9hA-1jlkA:
undetectable		 2w9hA-1jlkA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 1jlk RESPONSE REGULATOR
RCP1
(Synechocystis
sp.
PCC
6803) 		4 / 8 LEU A  13
LEU A  23
LEU A  28
ARG A  22
 None
 1.14A 2xn3A-1jlkA:
0.0
2xn3B-1jlkA:
undetectable		 2xn3A-1jlkA:
19.58
2xn3B-1jlkA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1jlk RESPONSE REGULATOR
RCP1
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU A  71
ALA A  45
LEU A  12
VAL A  14
ILE A  83
 None
 0.97A 3frbX-1jlkA:
undetectable		 3frbX-1jlkA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1jlk RESPONSE REGULATOR
RCP1
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A  50
ALA A  48
LEU A  44
ILE A  65
LEU A  40
 None
 1.24A 3olsB-1jlkA:
undetectable		 3olsB-1jlkA:
21.31