SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jmc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 1jmc PROTEIN (REPLICATION
PROTEIN A (RPA))
(Homo
sapiens) 		5 / 12 GLU A 225
ILE A 233
ASP A 275
ILE A 187
ALA A 201
 None
 1.07A 1kijB-1jmcA:
undetectable		 1kijB-1jmcA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 1jmc PROTEIN (REPLICATION
PROTEIN A (RPA))
(Homo
sapiens) 		4 / 4 SER A 207
VAL A 203
PHE A 246
VAL A 242
 None
 1.49A 1o86A-1jmcA:
undetectable		 1o86A-1jmcA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1jmc PROTEIN (REPLICATION
PROTEIN A (RPA))
(Homo
sapiens) 		5 / 8 ALA A 358
ILE A 378
ILE A 319
GLY A 321
ILE A 322
 None
 1.37A 1sh9A-1jmcA:
undetectable		 1sh9A-1jmcA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 1jmc PROTEIN (REPLICATION
PROTEIN A (RPA))
(Homo
sapiens) 		3 / 3 GLU A 283
GLY A 260
THR A 261
 None
 0.42A 3iazA-1jmcA:
0.0		 3iazA-1jmcA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1jmc PROTEIN (REPLICATION
PROTEIN A (RPA))
(Homo
sapiens) 		4 / 5 GLY A 231
ASP A 228
GLU A 225
VAL A 251
 None
 1.17A 4nkvD-1jmcA:
0.0		 4nkvD-1jmcA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1jmc PROTEIN (REPLICATION
PROTEIN A (RPA))
(Homo
sapiens) 		3 / 3 ARG A 412
ASN A 402
ASP A 369
 None
 0.92A 5gwxA-1jmcA:
undetectable		 5gwxA-1jmcA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1jmc PROTEIN (REPLICATION
PROTEIN A (RPA))
(Homo
sapiens) 		3 / 3 GLY A 260
THR A 279
ASN A 281
 None
 0.70A 5odiG-1jmcA:
undetectable		 5odiG-1jmcA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1jmc PROTEIN (REPLICATION
PROTEIN A (RPA))
(Homo
sapiens) 		3 / 3 PHE A 415
ARG A 412
GLN A 420
 None
 1.02A 6g1pB-1jmcA:
undetectable		 6g1pB-1jmcA:
20.56