SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jmm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 1jmm PROTEIN I/II
V-REGION
(Streptococcus
mutans) 		5 / 12 LEU A 645
GLY A 654
ASP A 650
ALA A 606
ILE A 647
 None
 0.86A 1rl8B-1jmmA:
undetectable		 1rl8B-1jmmA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1jmm PROTEIN I/II
V-REGION
(Streptococcus
mutans) 		3 / 3 LYS A 739
SER A 753
GLN A 754
 None
 1.23A 3si7A-1jmmA:
undetectable		 3si7A-1jmmA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 1jmm PROTEIN I/II
V-REGION
(Streptococcus
mutans) 		4 / 5 THR A 631
ILE A 672
LYS A 673
PHE A 638
 None
 1.47A 4ac9C-1jmmA:
undetectable		 4ac9C-1jmmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1jmm PROTEIN I/II
V-REGION
(Streptococcus
mutans) 		4 / 5 THR A 631
ILE A 672
LYS A 673
PHE A 638
 None
 1.46A 4acaC-1jmmA:
undetectable		 4acaC-1jmmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1jmm PROTEIN I/II
V-REGION
(Streptococcus
mutans) 		4 / 5 THR A 631
ILE A 672
LYS A 673
PHE A 638
 None
 1.43A 4acbC-1jmmA:
undetectable		 4acbC-1jmmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1jmm PROTEIN I/II
V-REGION
(Streptococcus
mutans) 		4 / 8 ASP A 760
ASP A 554
ASP A 555
ASN A 699
 NA  A3001 ( 4.4A)
None
None
NA  A3001 (-3.4A)
 1.10A 4feuD-1jmmA:
undetectable		 4feuD-1jmmA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1jmm PROTEIN I/II
V-REGION
(Streptococcus
mutans) 		5 / 11 GLY A 821
GLY A 620
ILE A 623
PHE A 678
PHE A 688
 None
 0.98A 4qoiA-1jmmA:
undetectable
4qoiB-1jmmA:
undetectable		 4qoiA-1jmmA:
21.04
4qoiB-1jmmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_1
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 1jmm PROTEIN I/II
V-REGION
(Streptococcus
mutans) 		4 / 6 LEU A 736
GLU A 742
LYS A 805
TYR A 750
 None
 1.48A 4wcxC-1jmmA:
undetectable		 4wcxC-1jmmA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 1jmm PROTEIN I/II
V-REGION
(Streptococcus
mutans) 		5 / 9 ALA A 696
GLY A 772
ALA A 732
SER A 722
GLY A 724
 None
 1.07A 6bklE-1jmmA:
undetectable
6bklF-1jmmA:
undetectable
6bklG-1jmmA:
undetectable
6bklH-1jmmA:
undetectable		 6bklE-1jmmA:
5.11
6bklF-1jmmA:
5.11
6bklG-1jmmA:
5.11
6bklH-1jmmA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1jmm PROTEIN I/II
V-REGION
(Streptococcus
mutans) 		4 / 9 VAL A 828
LEU A 693
SER A 818
ASP A 512
 None
 0.97A 6c2mD-1jmmA:
undetectable		 6c2mD-1jmmA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1jmm PROTEIN I/II
V-REGION
(Streptococcus
mutans) 		5 / 12 GLY A 662
GLY A 575
THR A 585
LEU A 553
THR A 541
 None
 1.21A 6e8qA-1jmmA:
undetectable		 6e8qA-1jmmA:
12.47