SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jmo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		6 / 12 ILE A 460
LEU A 375
PHE A 456
PHE A 458
PRO A 477
LEU A 380
 None
 1.21A 1drfA-1jmoA:
undetectable		 1drfA-1jmoA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		6 / 12 ILE A 460
PHE A 456
PHE A 458
PRO A 477
LEU A 380
TYR A 330
 None
 1.31A 1drfA-1jmoA:
undetectable		 1drfA-1jmoA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		4 / 4 GLY A 144
SER A 147
ILE A 176
HIS A 159
 None
 1.21A 1yajJ-1jmoA:
undetectable		 1yajJ-1jmoA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		5 / 11 VAL A 221
PHE A 217
GLY A 144
ILE A 270
LEU A 205
 None
 0.91A 1z11A-1jmoA:
0.0		 1z11A-1jmoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		5 / 11 VAL A 221
PHE A 217
GLY A 144
ILE A 270
LEU A 205
 None
 0.93A 1z11B-1jmoA:
0.0		 1z11B-1jmoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		5 / 12 ILE A 460
LEU A 375
PHE A 458
PRO A 477
LEU A 380
 None
 1.17A 2w3bB-1jmoA:
undetectable		 2w3bB-1jmoA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		5 / 12 ILE A 460
LEU A 375
PHE A 456
PHE A 458
ASN A 131
 None
 1.31A 2w3mB-1jmoA:
undetectable		 2w3mB-1jmoA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		5 / 11 ILE A 270
LEU A 205
ILE A 408
VAL A 158
LEU A 398
 None
 0.92A 3a51A-1jmoA:
0.0		 3a51A-1jmoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		5 / 12 ILE A 270
LEU A 205
ILE A 408
VAL A 158
LEU A 398
 None
 0.95A 3a51D-1jmoA:
0.0		 3a51D-1jmoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		4 / 8 GLY A 394
PHE A 183
PHE A 114
PHE A 164
 None
 1.05A 3ko0D-1jmoA:
undetectable
3ko0E-1jmoA:
undetectable		 3ko0D-1jmoA:
11.67
3ko0E-1jmoA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		3 / 3 GLN A 267
THR A 266
LEU A 398
 None
 0.76A 3ondA-1jmoA:
undetectable		 3ondA-1jmoA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		3 / 3 GLN A 267
THR A 266
LEU A 398
 None
 0.76A 3ondB-1jmoA:
undetectable		 3ondB-1jmoA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		5 / 12 LEU A 386
LEU A 457
MET A 471
ILE A 134
ILE A 139
 None
 1.09A 4ltwA-1jmoA:
undetectable		 4ltwA-1jmoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		6 / 12 ILE A 460
LEU A 375
PHE A 456
PHE A 458
PRO A 477
TYR A 330
 None
 1.34A 4m6kA-1jmoA:
undetectable		 4m6kA-1jmoA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		6 / 12 ILE A 460
LEU A 375
PHE A 458
PRO A 477
LEU A 380
TYR A 330
 None
 1.33A 4m6kA-1jmoA:
undetectable		 4m6kA-1jmoA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		4 / 7 ASP A 453
THR A 451
PHE A 294
HIS A 292
 None
 1.50A 4o4dA-1jmoA:
0.0		 4o4dA-1jmoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		3 / 3 LEU A 162
LEU A  95
ASN A 108
 None
 0.60A 4otwA-1jmoA:
undetectable		 4otwA-1jmoA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		3 / 3 LEU A 417
PHE A 399
ILE A 270
 None
 0.75A 5dzk1-1jmoA:
undetectable
5dzkF-1jmoA:
0.0
5dzkM-1jmoA:
0.0		 5dzk1-1jmoA:
5.56
5dzkF-1jmoA:
15.93
5dzkM-1jmoA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		5 / 12 VAL A 452
ASP A 453
LEU A 350
THR A 349
ARG A 295
 None
None
None
None
TYS  A  60 ( 3.9A)
 1.38A 5hnxB-1jmoA:
undetectable		 5hnxB-1jmoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		4 / 7 THR A 187
LEU A 148
VAL A 158
GLU A 175
 None
 0.95A 5tudA-1jmoA:
0.4		 5tudA-1jmoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		4 / 5 HIS A 159
SER A 147
GLY A 144
TYR A 225
 None
 1.18A 5yodB-1jmoA:
0.0		 5yodB-1jmoA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		4 / 5 HIS A 159
SER A 147
GLY A 144
TYR A 225
 None
 1.06A 5yodD-1jmoA:
undetectable		 5yodD-1jmoA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		4 / 5 HIS A 159
SER A 147
GLY A 144
TYR A 225
 None
 1.05A 5yodH-1jmoA:
undetectable		 5yodH-1jmoA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		3 / 3 ARG A 120
LYS A 123
ARG A 479
 None
 1.34A 6c06D-1jmoA:
0.0		 6c06D-1jmoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 1jmo HEPARIN COFACTOR II
(Homo
sapiens) 		5 / 10 LEU A 468
LEU A 186
MET A 143
THR A 141
LEU A 162
 None
 1.38A 6hupD-1jmoA:
0.0
6hupE-1jmoA:
undetectable		 6hupD-1jmoA:
10.87
6hupE-1jmoA:
11.11