SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jne'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		5 / 9 ALA A 115
PHE A 111
GLY A  42
ALA A  41
LEU A 127
 None
 1.05A 1nr6A-1jneA:
undetectable		 1nr6A-1jneA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		5 / 12 PHE A 133
LEU A 127
VAL A 180
PHE A 111
VAL A  83
 None
 1.37A 1q23C-1jneA:
0.0		 1q23C-1jneA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		5 / 11 PHE A 133
LEU A 127
VAL A 180
PHE A 111
VAL A  83
 None
 1.36A 1q23F-1jneA:
0.0		 1q23F-1jneA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		5 / 11 PHE A 133
LEU A 127
VAL A 180
PHE A 111
VAL A  83
 None
 1.37A 1q23L-1jneA:
0.0		 1q23L-1jneA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		5 / 9 PHE A 173
VAL A 177
LEU A 191
PHE A 205
LEU A 129
 None
 1.21A 1wrkA-1jneA:
undetectable
1wrkB-1jneA:
undetectable		 1wrkA-1jneA:
11.25
1wrkB-1jneA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		4 / 6 PHE A 173
VAL A 177
LEU A 191
PHE A 205
 None
 1.03A 1wrlB-1jneA:
undetectable		 1wrlB-1jneA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		5 / 12 ALA A 255
GLN A 258
ASN A 273
LEU A 219
ILE A 416
 None
NAG  A3100 (-3.3A)
None
None
None
 1.00A 2aclA-1jneA:
undetectable
2aclE-1jneA:
undetectable		 2aclA-1jneA:
21.28
2aclE-1jneA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		5 / 11 ALA A 255
GLN A 258
ASN A 273
LEU A 219
ILE A 416
 None
NAG  A3100 (-3.3A)
None
None
None
 0.98A 2aclE-1jneA:
undetectable		 2aclE-1jneA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		4 / 6 LEU A 315
ALA A 277
HIS A  87
LYS A 312
 None
 1.11A 2dpzA-1jneA:
undetectable		 2dpzA-1jneA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		4 / 8 ASP A  58
SER A  10
TYR A   7
TYR A  40
 None
 0.88A 2xz5A-1jneA:
0.0
2xz5C-1jneA:
0.0		 2xz5A-1jneA:
20.00
2xz5C-1jneA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		4 / 5 ILE A  98
PHE A 173
VAL A  37
PHE A 111
 None
 1.22A 2ygnA-1jneA:
0.0		 2ygnA-1jneA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		4 / 6 PHE A 394
ASP A 128
TYR A   7
PRO A 197
 None
 1.44A 3jqaA-1jneA:
2.0		 3jqaA-1jneA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		4 / 6 PHE A 394
ASP A 128
TYR A   7
PRO A 197
 None
 1.43A 3jqaB-1jneA:
3.3		 3jqaB-1jneA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		4 / 6 PHE A 394
ASP A 128
TYR A   7
PRO A 197
 None
 1.49A 3jqaC-1jneA:
3.6		 3jqaC-1jneA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		4 / 6 PHE A 394
ASP A 128
TYR A   7
PRO A 197
 None
 1.44A 3jqaD-1jneA:
3.3		 3jqaD-1jneA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		4 / 7 LEU A  43
ALA A  41
ASP A  88
TYR A 131
 None
 1.17A 3rodD-1jneA:
undetectable		 3rodD-1jneA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		5 / 12 TYR A 398
GLY A 280
ILE A 240
GLY A 352
ALA A 376
 None
 1.05A 3sudB-1jneA:
undetectable		 3sudB-1jneA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		4 / 8 PHE A 267
GLY A 266
GLY A 389
ASN A 218
 None
 0.90A 3v3nB-1jneA:
undetectable		 3v3nB-1jneA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		4 / 8 PHE A 267
GLY A 266
GLY A 389
ASN A 218
 None
 0.90A 3v3nC-1jneA:
undetectable		 3v3nC-1jneA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		4 / 5 TYR A 398
SER A 397
GLY A  19
ARG A  15
 None
 1.08A 3v4tA-1jneA:
undetectable
3v4tD-1jneA:
undetectable		 3v4tA-1jneA:
22.08
3v4tD-1jneA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		4 / 8 ALA A 304
VAL A 368
GLY A 307
ILE A 366
 None
 0.68A 4ll3A-1jneA:
undetectable		 4ll3A-1jneA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		3 / 3 ARG A 249
HIS A 242
SER A 246
 None
MAN  A3103 (-3.8A)
None
 0.89A 4mjwA-1jneA:
0.0
4mjwB-1jneA:
0.0		 4mjwA-1jneA:
22.68
4mjwB-1jneA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		3 / 3 SER A 246
ARG A 249
HIS A 242
 None
None
MAN  A3103 (-3.8A)
 0.84A 4mjwA-1jneA:
0.0
4mjwB-1jneA:
0.0		 4mjwA-1jneA:
22.68
4mjwB-1jneA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		5 / 10 PHE A 111
ALA A  50
VAL A 180
LEU A 193
LEU A 176
 None
 1.26A 4zmeB-1jneA:
undetectable		 4zmeB-1jneA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		6 / 12 THR A 194
GLY A  84
GLY A  85
ALA A  50
ASP A 128
LEU A 127
 None
 1.32A 5c0oF-1jneA:
undetectable		 5c0oF-1jneA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		3 / 3 PHE A 394
ASP A   9
LEU A 316
 None
 0.75A 5uhbC-1jneA:
0.0		 5uhbC-1jneA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		3 / 3 PHE A 394
ASP A   9
LEU A 316
 None
 0.67A 5uhcC-1jneA:
undetectable		 5uhcC-1jneA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		4 / 8 TYR A 279
PHE A 222
PRO A 197
TYR A  40
 None
 1.07A 5v4vA-1jneA:
9.1		 5v4vA-1jneA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		4 / 8 TYR A 279
PHE A 222
PRO A 197
TYR A  40
 None
 1.10A 5v4vB-1jneA:
9.1		 5v4vB-1jneA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		4 / 6 ILE A  59
TYR A 122
LEU A 118
SER A  52
 None
 0.98A 6f6jA-1jneA:
0.0		 6f6jA-1jneA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		4 / 4 LYS A 379
LEU A 274
ALA A 380
LEU A 388
 None
 1.42A 6gnrA-1jneA:
0.0		 6gnrA-1jneA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		4 / 4 LYS A 379
LEU A 274
ALA A 380
LEU A 388
 None
 1.43A 6gnrB-1jneA:
0.0		 6gnrB-1jneA:
14.40