SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jnh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1jnh MONOCLONAL
ANTI-ESTRADIOL
10G6D6 FAB HEAVY
CHAIN
(Mus
musculus) 		5 / 12 VAL B 168
VAL B 186
SER B 184
ASN B 201
ASN B 160
 None
 1.45A 2y03A-1jnhB:
undetectable		 2y03A-1jnhB:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1jnh MONOCLONAL
ANTI-ESTRADIOL
10G6D6 FAB HEAVY
CHAIN
(Mus
musculus) 		5 / 12 VAL B 168
VAL B 186
SER B 184
ASN B 201
ASN B 160
 None
 1.48A 2y03B-1jnhB:
undetectable		 2y03B-1jnhB:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1jnh MONOCLONAL
ANTI-ESTRADIOL
10G6D6 FAB HEAVY
CHAIN
(Mus
musculus) 		5 / 11 GLN B   6
GLN B  82
LEU B  20
THR B 113
LEU B  70
 None
 1.46A 3fsuE-1jnhB:
undetectable		 3fsuE-1jnhB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 1jnh MONOCLONAL
ANTI-ESTRADIOL
10G6D6 FAB HEAVY
CHAIN
(Mus
musculus) 		5 / 12 VAL B 168
VAL B 186
SER B 184
ASN B 201
ASN B 160
 None
 1.40A 3nyaA-1jnhB:
undetectable		 3nyaA-1jnhB:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 1jnh MONOCLONAL
ANTI-ESTRADIOL
10G6D6 FAB HEAVY
CHAIN
(Mus
musculus) 		5 / 10 VAL B 168
VAL B 186
SER B 184
ASN B 201
ASN B 160
 None
 1.44A 4ldoA-1jnhB:
0.0		 4ldoA-1jnhB:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 1jnh MONOCLONAL
ANTI-ESTRADIOL
10G6D6 FAB HEAVY
CHAIN
(Mus
musculus) 		4 / 5 VAL B   2
TYR B  27
ARG B  98
TYR B 108
 None
 0.43A 4m7kH-1jnhB:
25.4		 4m7kH-1jnhB:
64.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 1jnh MONOCLONAL
ANTI-ESTRADIOL
10G6D6 FAB HEAVY
CHAIN
(Mus
musculus) 		5 / 12 VAL B 168
VAL B 186
SER B 184
ASN B 201
ASN B 160
 None
 1.43A 6h7mB-1jnhB:
undetectable		 6h7mB-1jnhB:
20.71