SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jof'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		5 / 10 LEU A   5
LEU A 334
THR A 327
PHE A  47
THR A  46
 None
 1.09A 1i18A-1jofA:
0.0
1i18B-1jofA:
0.0		 1i18A-1jofA:
15.31
1i18B-1jofA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		5 / 10 PHE A  47
THR A  46
LEU A   5
LEU A 334
THR A 327
 None
 1.10A 1i18A-1jofA:
0.0
1i18B-1jofA:
0.0		 1i18A-1jofA:
15.31
1i18B-1jofA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		4 / 8 HIS A 172
LEU A 182
LEU A 159
SER A 161
 None
 1.08A 1i7zA-1jofA:
undetectable		 1i7zA-1jofA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		5 / 11 MET A 324
THR A 327
GLY A 308
GLU A 335
SER A 311
 None
 1.49A 1odiB-1jofA:
undetectable		 1odiB-1jofA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		5 / 11 MET A 324
THR A 327
GLY A 308
GLU A 335
SER A 311
 None
 1.45A 1odiC-1jofA:
undetectable		 1odiC-1jofA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		4 / 7 THR A 306
GLU A 335
THR A 304
VAL A 259
 None
 1.12A 1tv8A-1jofA:
undetectable		 1tv8A-1jofA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		3 / 3 GLU A 296
GLU A 219
LEU A 262
 None
 0.62A 1v8bA-1jofA:
undetectable		 1v8bA-1jofA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		3 / 3 GLU A 296
GLU A 219
LEU A 262
 None
 0.61A 1v8bB-1jofA:
undetectable		 1v8bB-1jofA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		4 / 8 THR A 306
GLU A 335
THR A 304
VAL A 259
 None
 1.16A 2fb2A-1jofA:
undetectable		 2fb2A-1jofA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		3 / 3 ASN A 205
ILE A 295
MET A 269
 None
 0.82A 2h42C-1jofA:
undetectable		 2h42C-1jofA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		4 / 7 THR A  46
TYR A 139
ASN A 112
LEU A 159
 None
 1.07A 2hzqA-1jofA:
0.2		 2hzqA-1jofA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		3 / 3 HIS A   3
ILE A 336
LEU A  26
 BME  A 368 (-3.3A)
None
None
 0.71A 2kceA-1jofA:
undetectable		 2kceA-1jofA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		5 / 10 THR A   9
GLY A   8
GLY A  14
PHE A  65
ILE A  36
 None
 1.33A 2y7pA-1jofA:
undetectable		 2y7pA-1jofA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		5 / 11 ASN A 215
ALA A 257
ASP A 258
GLY A 282
PRO A 240
 None
 1.07A 3spkA-1jofA:
undetectable		 3spkA-1jofA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		3 / 3 ASP A 341
ARG A 338
LYS A 340
 None
 1.22A 3wipG-1jofA:
0.0		 3wipG-1jofA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		5 / 12 GLY A   8
ASN A 360
ILE A  36
PHE A  47
ILE A  54
 None
 1.19A 4fglA-1jofA:
undetectable
4fglB-1jofA:
undetectable		 4fglA-1jofA:
21.86
4fglB-1jofA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		5 / 11 GLY A 358
ILE A 336
THR A 304
PRO A 305
THR A 306
 None
 0.87A 4l1aA-1jofA:
undetectable		 4l1aA-1jofA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		5 / 12 GLY A   8
ASN A 360
ILE A  36
PHE A  47
ILE A  54
 None
 1.25A 4zvmA-1jofA:
undetectable
4zvmB-1jofA:
undetectable		 4zvmA-1jofA:
22.44
4zvmB-1jofA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		3 / 3 ARG A  86
THR A  92
ASP A  91
 None
 0.92A 5g5gA-1jofA:
0.0
5g5gB-1jofA:
0.0		 5g5gA-1jofA:
20.71
5g5gB-1jofA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		5 / 12 ASP A 329
ALA A 313
VAL A 259
THR A 306
PHE A 278
 None
 1.24A 5igiA-1jofA:
0.0		 5igiA-1jofA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		3 / 3 GLN A 330
THR A 306
ASP A 328
 None
 0.87A 5k9dA-1jofA:
undetectable		 5k9dA-1jofA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		3 / 3 LEU A 210
ALA A 209
LEU A 238
 None
 0.46A 5uunB-1jofA:
undetectable		 5uunB-1jofA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		4 / 7 PHE A 270
ILE A 295
SER A 265
THR A 263
 None
 0.96A 5vkqA-1jofA:
undetectable
5vkqD-1jofA:
undetectable		 5vkqA-1jofA:
11.64
5vkqD-1jofA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		4 / 7 SER A 265
THR A 263
PHE A 270
ILE A 295
 None
 1.00A 5vkqA-1jofA:
undetectable
5vkqB-1jofA:
undetectable		 5vkqA-1jofA:
11.64
5vkqB-1jofA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		4 / 8 SER A 265
THR A 263
PHE A 270
ILE A 295
 None
 1.01A 5vkqB-1jofA:
undetectable
5vkqC-1jofA:
undetectable		 5vkqB-1jofA:
11.64
5vkqC-1jofA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE
(Neurospora
crassa) 		4 / 7 SER A 265
THR A 263
PHE A 270
ILE A 295
 None
 0.98A 5vkqC-1jofA:
undetectable
5vkqD-1jofA:
undetectable		 5vkqC-1jofA:
11.64
5vkqD-1jofA:
11.64