SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jp4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE
(Rattus
norvegicus) 		3 / 3 ALA A 250
VAL A 116
TRP A 246
 None
 1.02A 1gmkA-1jp4A:
undetectable
1gmkB-1jp4A:
undetectable		 1gmkA-1jp4A:
3.97
1gmkB-1jp4A:
3.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE
(Rattus
norvegicus) 		5 / 12 ASP A 120
LEU A 270
GLY A 220
THR A 248
LEU A 262
 MG  A 701 (-3.1A)
None
AMP  A 601 (-3.5A)
None
None
 1.00A 1liiA-1jp4A:
undetectable		 1liiA-1jp4A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE
(Rattus
norvegicus) 		4 / 7 LEU A  62
ILE A  58
ALA A  15
ILE A 150
 None
 1.00A 1oniB-1jp4A:
0.0
1oniC-1jp4A:
undetectable		 1oniB-1jp4A:
19.68
1oniC-1jp4A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE
(Rattus
norvegicus) 		4 / 7 LEU A 306
ILE A 207
PRO A 299
ILE A 265
 None
 0.79A 2aojB-1jp4A:
undetectable		 2aojB-1jp4A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQJ_A_TRPA650_0
(TRYPTOPHAN
HALOGENASE, PRNA)		 1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE
(Rattus
norvegicus) 		5 / 11 PRO A 269
ILE A 265
TYR A 272
GLU A 252
ASN A 280
 None
 1.23A 2aqjA-1jp4A:
0.3		 2aqjA-1jp4A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKC_A_TRPA1520_0
(FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA)		 1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE
(Rattus
norvegicus) 		5 / 10 PRO A 269
ILE A 265
TYR A 272
GLU A 252
ASN A 280
 None
 1.35A 2jkcA-1jp4A:
0.0		 2jkcA-1jp4A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2002_0
(TRYPTOPHAN
HALOGENASE)		 1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE
(Rattus
norvegicus) 		5 / 12 PRO A 269
ILE A 265
TYR A 272
GLU A 252
ASN A 280
 None
 1.32A 2oa1A-1jp4A:
0.2		 2oa1A-1jp4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2003_0
(TRYPTOPHAN
HALOGENASE)		 1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE
(Rattus
norvegicus) 		5 / 12 PRO A 269
ILE A 265
TYR A 272
GLU A 252
ASN A 280
 None
 1.33A 2oa1B-1jp4A:
1.2		 2oa1B-1jp4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE
(Rattus
norvegicus) 		4 / 8 VAL A 237
CYH A 243
TYR A 236
VAL A 203
 None
AMP  A 601 (-4.1A)
None
None
 0.99A 4aftD-1jp4A:
0.0
4aftE-1jp4A:
0.0		 4aftD-1jp4A:
21.68
4aftE-1jp4A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE
(Rattus
norvegicus) 		5 / 12 ASP A 120
LEU A 270
GLY A 220
THR A 248
LEU A 262
 MG  A 701 (-3.1A)
None
AMP  A 601 (-3.5A)
None
None
 0.92A 4dc3A-1jp4A:
undetectable		 4dc3A-1jp4A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE
(Rattus
norvegicus) 		5 / 12 ASP A 120
LEU A 270
GLY A 220
THR A 248
LEU A 262
 MG  A 701 (-3.1A)
None
AMP  A 601 (-3.5A)
None
None
 0.93A 4dc3B-1jp4A:
undetectable		 4dc3B-1jp4A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE
(Rattus
norvegicus) 		5 / 11 ILE A 191
ALA A 185
GLY A 231
GLU A 230
GLY A 260
 None
 1.20A 4e47A-1jp4A:
undetectable		 4e47A-1jp4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE
(Rattus
norvegicus) 		5 / 11 ILE A 191
ALA A 185
GLY A 231
GLU A 230
GLY A 260
 None
 1.21A 4e47B-1jp4A:
undetectable		 4e47B-1jp4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE
(Rattus
norvegicus) 		4 / 6 ASP A 117
ASP A 247
ASN A 280
ASP A 120
 MG  A 702 (-2.5A)
MG  A 701 ( 2.7A)
None
MG  A 701 (-3.1A)
 1.21A 4mdaA-1jp4A:
0.0		 4mdaA-1jp4A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE
(Rattus
norvegicus) 		5 / 8 SER A  14
LEU A  62
LEU A  69
VAL A 114
ILE A 139
 None
 1.40A 4oj4A-1jp4A:
0.0		 4oj4A-1jp4A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE
(Rattus
norvegicus) 		5 / 12 TYR A 272
GLY A 148
GLY A 138
ILE A 146
ILE A 150
 None
 0.86A 4qtuB-1jp4A:
undetectable		 4qtuB-1jp4A:
21.18