SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jpl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 1jpl ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens) 		3 / 3 ARG A  79
GLN A  44
PRO A  43
 None
 0.80A 2qhfA-1jplA:
undetectable		 2qhfA-1jplA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 1jpl ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens) 		3 / 3 MET A 123
VAL A  84
GLU A  70
 None
 0.83A 2x9gA-1jplA:
3.2		 2x9gA-1jplA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 1jpl ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens) 		5 / 12 ASN A  75
GLY A  77
VAL A  84
LEU A  69
ILE A  30
 None
 1.31A 3mnoA-1jplA:
undetectable		 3mnoA-1jplA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 1jpl ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens) 		5 / 12 ASN A  75
GLY A  77
VAL A  84
LEU A  69
ILE A  30
 None
 1.32A 3mnpA-1jplA:
undetectable		 3mnpA-1jplA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1jpl ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens) 		4 / 8 LEU A 118
VAL A  97
VAL A 144
LEU A  93
 None
 1.04A 4pwdC-1jplA:
undetectable		 4pwdC-1jplA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 1jpl ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens) 		4 / 8 LEU A  69
PHE A  89
LEU A 118
ILE A 131
 None
 0.97A 5mzjA-1jplA:
2.1		 5mzjA-1jplA:
18.27