SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jpu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 8 ASP A 100
ILE A 113
GLY A  92
PRO A 125
ALA A 124
 None
 1.21A 1sguA-1jpuA:
undetectable		 1sguA-1jpuA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 242
ALA A 205
LEU A 245
SER A 249
 None
 1.13A 1tt6B-1jpuA:
undetectable		 1tt6B-1jpuA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 256
ASP A 173
THR A 122
LEU A 252
GLY A 251
 ZN  A 371 (-3.2A)
ZN  A 371 (-2.1A)
None
None
None
 1.36A 1v8bB-1jpuA:
4.0		 1v8bB-1jpuA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 6 ILE A 325
ALA A 329
THR A 333
ALA A 254
 None
 0.68A 1w0gA-1jpuA:
undetectable		 1w0gA-1jpuA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 308
CYH A 208
ASP A 173
ALA A 174
ALA A 238
 None
None
ZN  A 371 (-2.1A)
None
None
 1.11A 2br4A-1jpuA:
2.7		 2br4A-1jpuA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 9 ILE A 204
ILE A 199
GLU A 202
ALA A 203
THR A 198
 None
 1.33A 2dtjA-1jpuA:
undetectable
2dtjB-1jpuA:
undetectable		 2dtjA-1jpuA:
19.46
2dtjB-1jpuA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 5 HIS A 259
HIS A 256
VAL A 278
HIS A 274
 None
ZN  A 371 (-3.2A)
None
ZN  A 371 (-3.3A)
 0.94A 2wkoF-1jpuA:
undetectable		 2wkoF-1jpuA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		3 / 3 SER A 243
GLU A 180
ASP A 173
 None
None
ZN  A 371 (-2.1A)
 0.76A 2zthA-1jpuA:
4.0		 2zthA-1jpuA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		3 / 3 SER A 243
GLU A 180
ASP A 173
 None
None
ZN  A 371 (-2.1A)
 0.81A 3bwmA-1jpuA:
3.7		 3bwmA-1jpuA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		3 / 3 SER A 243
GLU A 180
ASP A 173
 None
None
ZN  A 371 (-2.1A)
 0.74A 3bwyA-1jpuA:
3.7		 3bwyA-1jpuA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 6 ALA A 200
LEU A 245
SER A 249
THR A 198
 None
 1.07A 3cfqA-1jpuA:
undetectable		 3cfqA-1jpuA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 174
GLY A 170
LEU A 175
GLY A 244
SER A 243
 None
 0.88A 3g2oA-1jpuA:
undetectable		 3g2oA-1jpuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 174
LEU A 175
SER A 169
GLY A 244
SER A 243
 None
 1.02A 3g2oA-1jpuA:
undetectable		 3g2oA-1jpuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		6 / 12 GLU A 180
LEU A 252
LEU A 175
SER A 169
GLY A 244
SER A 243
 None
 1.29A 3g2oA-1jpuA:
undetectable		 3g2oA-1jpuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 174
GLY A 170
LEU A 175
GLY A 244
SER A 243
 None
 0.89A 3g2oB-1jpuA:
2.9		 3g2oB-1jpuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 262
PHE A 280
ALA A 279
THR A 282
 None
 1.18A 3t3sB-1jpuA:
0.0		 3t3sB-1jpuA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 259
GLY A 281
HIS A 256
ASP A 173
GLY A 275
 None
None
ZN  A 371 (-3.2A)
ZN  A 371 (-2.1A)
None
 1.23A 4bz6C-1jpuA:
3.0		 4bz6C-1jpuA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 265
ILE A 354
VAL A 350
GLY A 261
 None
 0.81A 4eq4B-1jpuA:
undetectable		 4eq4B-1jpuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A  45
THR A 240
VAL A 236
ILE A 159
GLU A 233
 None
 0.92A 4i41A-1jpuA:
undetectable		 4i41A-1jpuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  27
LEU A  99
ILE A  91
ILE A  89
ALA A 111
 None
 0.98A 4ltwA-1jpuA:
undetectable		 4ltwA-1jpuA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 259
GLY A 281
HIS A 256
ASP A 173
GLY A 275
 None
None
ZN  A 371 (-3.2A)
ZN  A 371 (-2.1A)
None
 1.23A 4lxzC-1jpuA:
undetectable		 4lxzC-1jpuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 259
GLY A 281
HIS A 256
ASP A 173
GLY A 275
 None
None
ZN  A 371 (-3.2A)
ZN  A 371 (-2.1A)
None
 1.29A 4qa0A-1jpuA:
3.1		 4qa0A-1jpuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 9 ALA A 253
THR A 338
ALA A 254
ILE A 185
GLY A 189
 None
 1.14A 4qvqK-1jpuA:
undetectable
4qvqL-1jpuA:
undetectable		 4qvqK-1jpuA:
20.60
4qvqL-1jpuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 9 ALA A 253
THR A 338
ALA A 254
ILE A 185
GLY A 189
 None
 1.14A 4qvqY-1jpuA:
undetectable
4qvqZ-1jpuA:
undetectable		 4qvqY-1jpuA:
20.60
4qvqZ-1jpuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 274
GLY A 275
TYR A 142
VAL A 184
GLY A 281
 ZN  A 371 (-3.3A)
None
None
None
None
 1.22A 5hg0A-1jpuA:
undetectable		 5hg0A-1jpuA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A 284
GLN A 285
ALA A 332
VAL A 350
SER A 183
 None
 0.98A 5hv1A-1jpuA:
undetectable		 5hv1A-1jpuA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A 284
GLN A 285
VAL A 350
SER A 183
MET A 192
 None
 0.99A 5hv1A-1jpuA:
undetectable		 5hv1A-1jpuA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 5 HIS A 256
HIS A 274
VAL A 278
ALA A 255
 ZN  A 371 (-3.2A)
ZN  A 371 (-3.3A)
None
None
 1.39A 5i3bB-1jpuA:
undetectable		 5i3bB-1jpuA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		3 / 3 HIS A 291
SER A 292
ARG A 298
 None
 0.96A 5u63A-1jpuA:
0.8		 5u63A-1jpuA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 325
ALA A 329
THR A 333
ILE A 339
ALA A 254
 None
 1.00A 5vceA-1jpuA:
undetectable		 5vceA-1jpuA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1jpu GLYCEROL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A 365
LEU A 283
ASP A 314
 None
 0.87A 5zv2A-1jpuA:
undetectable		 5zv2A-1jpuA:
12.50