SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jqe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 11 LEU A  71
ASP A  67
ILE A 171
ILE A  59
ILE A  70
 None
 0.90A 1c6yA-1jqeA:
undetectable		 1c6yA-1jqeA:
16.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 7 PHE A  22
GLU A  28
GLN A 143
VAL A 173
TRP A 179
TRP A 183
ASN A 283
 None
None
None
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
None
 0.38A 1jqdA-1jqeA:
42.3		 1jqdA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 PHE A 243
GLN A 143
VAL A 173
TRP A 179
 QUN  A 500 (-4.1A)
None
None
QUN  A 500 (-3.6A)
 1.20A 1jqdA-1jqeA:
42.3		 1jqdA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JQD_B_HSMB601_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		10 / 10 PHE A  22
GLU A  28
GLN A 143
TYR A 146
VAL A 173
TRP A 179
TRP A 183
PHE A 243
ASN A 283
LEU A 285
 None
None
None
QUN  A 500 (-3.3A)
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-4.1A)
None
None
 0.37A 1jqdB-1jqeA:
42.8		 1jqdB-1jqeA:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 GLU A  86
ASN A  84
TRP A 136
 None
 1.23A 1r15F-1jqeA:
undetectable		 1r15F-1jqeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 12 ILE A  59
GLY A  60
GLY A  62
ILE A 142
SER A  91
GLU A 118
 None
SAH  A 400 (-3.3A)
SAH  A 400 (-3.2A)
SAH  A 400 (-4.1A)
SAH  A 400 (-4.7A)
None
 1.44A 1sg9B-1jqeA:
7.5		 1sg9B-1jqeA:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOT_A_2PMA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		8 / 10 GLN A 143
TYR A 146
TYR A 147
VAL A 173
TRP A 179
TRP A 183
TYR A 198
PHE A 243
 None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
None
QUN  A 500 (-4.1A)
 0.48A 2aotA-1jqeA:
42.6		 2aotA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOT_A_2PMA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 10 TYR A 146
TYR A 147
VAL A 173
TRP A 179
PHE A  22
 QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
None
QUN  A 500 (-3.6A)
None
 1.29A 2aotA-1jqeA:
42.6		 2aotA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOT_B_2PMB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		9 / 12 PHE A  22
GLN A 143
TYR A 146
TYR A 147
TRP A 179
TRP A 183
CYH A 196
TYR A 198
PHE A 243
 None
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
None
QUN  A 500 (-4.1A)
 0.60A 2aotB-1jqeA:
42.5		 2aotB-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOT_B_2PMB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		8 / 12 PHE A  22
TYR A 146
TYR A 147
TRP A 183
CYH A 196
TYR A 198
PHE A 243
GLU A 246
 None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
None
QUN  A 500 (-4.1A)
QUN  A 500 (-3.9A)
 0.84A 2aotB-1jqeA:
42.5		 2aotB-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		9 / 12 GLU A  28
GLN A  94
GLN A 143
TYR A 146
TYR A 147
VAL A 173
TRP A 179
TRP A 183
CYH A 196
 None
SAH  A 400 (-3.8A)
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
 0.51A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		9 / 12 GLU A  28
GLN A  94
GLN A 143
TYR A 146
VAL A 173
TRP A 179
TRP A 183
CYH A 196
GLU A 246
 None
SAH  A 400 (-3.8A)
None
QUN  A 500 (-3.3A)
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
QUN  A 500 (-3.9A)
 0.86A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		8 / 12 PHE A  19
GLN A  94
TYR A 146
TYR A 147
VAL A 173
TRP A 179
TRP A 183
CYH A 196
 SAH  A 400 (-3.9A)
SAH  A 400 (-3.8A)
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
 0.78A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		8 / 12 PHE A  19
GLN A  94
TYR A 146
VAL A 173
TRP A 179
TRP A 183
CYH A 196
GLU A 246
 SAH  A 400 (-3.9A)
SAH  A 400 (-3.8A)
QUN  A 500 (-3.3A)
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
QUN  A 500 (-3.9A)
 1.07A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 PHE A  22
GLN A 143
TYR A 146
CYH A 196
GLU A 246
 None
None
QUN  A 500 (-3.3A)
QUN  A 500 (-3.6A)
QUN  A 500 (-3.9A)
 1.37A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 PHE A  22
GLN A 143
TYR A 146
TYR A 147
CYH A 196
 None
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
QUN  A 500 (-3.6A)
 1.43A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 PHE A  22
GLN A 143
TYR A 146
VAL A 172
CYH A 196
 None
None
QUN  A 500 (-3.3A)
None
QUN  A 500 (-3.6A)
 1.45A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 8 ASP A 180
TRP A 183
LYS A 184
GLY A 187
PHE A 190
THR A 247
 None
QUN  A 500 (-4.9A)
None
None
None
None
 1.07A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 8 ASP A 180
TRP A 183
LYS A 184
PHE A 190
TYR A 198
THR A 247
 None
QUN  A 500 (-4.9A)
None
None
None
None
 1.09A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 8 TRP A 183
LYS A 181
PHE A 190
TYR A 198
THR A 247
 QUN  A 500 (-4.9A)
None
None
None
None
 1.25A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_B_CQAB400_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLN A  94
TYR A 146
VAL A 173
TRP A 183
PHE A  22
 SAH  A 400 (-3.8A)
QUN  A 500 (-3.3A)
None
QUN  A 500 (-4.9A)
None
 1.42A 2aouB-1jqeA:
42.9		 2aouB-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_B_CQAB400_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		9 / 12 GLU A  28
GLN A  94
GLN A 143
TYR A 146
VAL A 173
TRP A 183
CYH A 196
PHE A 243
GLU A 246
 None
SAH  A 400 (-3.8A)
None
QUN  A 500 (-3.3A)
None
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.1A)
QUN  A 500 (-3.9A)
 0.87A 2aouB-1jqeA:
42.9		 2aouB-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_B_CQAB400_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		10 / 12 GLU A  28
SER A  91
GLN A  94
GLN A 143
TYR A 146
TYR A 147
VAL A 173
TRP A 183
CYH A 196
PHE A 243
 None
SAH  A 400 (-4.7A)
SAH  A 400 (-3.8A)
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
None
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.1A)
 0.64A 2aouB-1jqeA:
42.9		 2aouB-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 TRP A 183
GLY A 187
PHE A 190
THR A 247
 QUN  A 500 (-4.9A)
None
None
None
 1.04A 2aouB-1jqeA:
42.9		 2aouB-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 TRP A 183
PHE A 190
TYR A 198
THR A 247
 QUN  A 500 (-4.9A)
None
None
None
 1.03A 2aouB-1jqeA:
42.9		 2aouB-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 7 PHE A  22
GLU A  28
GLN A 143
TYR A 147
TRP A 179
TRP A 183
GLU A 246
 None
None
None
QUN  A 500 ( 3.6A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.9A)
 0.74A 2aowA-1jqeA:
40.2		 2aowA-1jqeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOW_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		9 / 9 PHE A  22
GLU A  28
GLN A 143
TYR A 146
TYR A 147
TRP A 179
TRP A 183
CYH A 196
GLU A 246
 None
None
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
QUN  A 500 (-3.9A)
 0.76A 2aowB-1jqeA:
40.2		 2aowB-1jqeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 8 PHE A  19
PHE A  22
GLU A  28
TYR A 146
TYR A 147
TRP A 179
TRP A 183
 SAH  A 400 (-3.9A)
None
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
 0.76A 2aoxA-1jqeA:
39.8		 2aoxA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 8 PHE A  22
GLU A  28
GLN A 143
TYR A 146
TYR A 147
TRP A 179
TRP A 183
 None
None
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
 0.51A 2aoxA-1jqeA:
39.8		 2aoxA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOX_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 7 PHE A  19
PHE A  22
GLU A  28
GLN A 143
TYR A 147
TRP A 179
TRP A 183
 SAH  A 400 (-3.9A)
None
None
None
QUN  A 500 ( 3.6A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
 0.80A 2aoxB-1jqeA:
39.8		 2aoxB-1jqeA:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 9 LEU A  71
ASP A  67
ILE A 171
ILE A  59
ILE A  70
 None
 1.01A 2avoA-1jqeA:
undetectable		 2avoA-1jqeA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 151
GLY A  60
LEU A 161
TYR A 123
MET A 127
 None
SAH  A 400 (-3.3A)
None
None
None
 1.27A 2nyrB-1jqeA:
2.0		 2nyrB-1jqeA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 TYR A 146
PRO A 152
ALA A 153
MET A 141
MET A 207
 QUN  A 500 (-3.3A)
None
None
None
None
 0.98A 2x2nB-1jqeA:
undetectable		 2x2nB-1jqeA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 5 ILE A 151
MET A 168
LEU A 211
LEU A 208
 None
 1.16A 2zb7A-1jqeA:
3.3		 2zb7A-1jqeA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 5 LEU A  71
ASP A  67
ILE A  54
ILE A  70
 None
 0.97A 3bufA-1jqeA:
undetectable		 3bufA-1jqeA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 9 LEU A  71
ASP A  67
ILE A 171
ILE A  59
ILE A  70
 None
 1.06A 3d1yB-1jqeA:
undetectable		 3d1yB-1jqeA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 9 LEU A  71
ASP A  67
ILE A 171
ILE A 139
ILE A  70
 None
 1.14A 3d1yB-1jqeA:
undetectable		 3d1yB-1jqeA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 237
ASN A 236
GLY A 263
LEU A 240
THR A 245
 None
 1.10A 3eeyA-1jqeA:
11.9		 3eeyA-1jqeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 237
ASN A 236
GLY A 263
LEU A 240
THR A 245
 None
 1.07A 3eeyB-1jqeA:
11.9		 3eeyB-1jqeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 237
ASN A 236
GLY A 263
LEU A 240
THR A 245
 None
 1.08A 3eeyC-1jqeA:
12.0		 3eeyC-1jqeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 237
ASN A 236
GLY A 263
LEU A 240
THR A 245
 None
 1.08A 3eeyD-1jqeA:
12.0		 3eeyD-1jqeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 9 LEU A  71
ASP A  67
ILE A 171
ILE A  59
ILE A  70
 None
 1.00A 3ekqB-1jqeA:
undetectable		 3ekqB-1jqeA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A  59
GLY A  60
GLY A  61
PRO A  90
ILE A 142
 None
SAH  A 400 (-3.3A)
SAH  A 400 ( 4.1A)
SAH  A 400 (-4.3A)
SAH  A 400 (-4.1A)
 0.63A 3jayA-1jqeA:
9.6		 3jayA-1jqeA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 GLY A  64
TRP A 115
VAL A  87
 None
 0.60A 3n62B-1jqeA:
0.0		 3n62B-1jqeA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 GLY A  64
TRP A 115
VAL A  87
 None
 0.61A 3n65B-1jqeA:
0.0		 3n65B-1jqeA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 GLY A  64
TRP A 115
VAL A  87
 None
 0.62A 3n66B-1jqeA:
undetectable		 3n66B-1jqeA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A  71
GLY A  64
ILE A 171
ILE A  59
ILE A  70
 None
 0.80A 3oxcB-1jqeA:
undetectable		 3oxcB-1jqeA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 11 ILE A 142
ILE A  70
VAL A  74
LEU A  71
VAL A 111
 SAH  A 400 (-4.1A)
None
None
None
None
 1.08A 3w67A-1jqeA:
undetectable		 3w67A-1jqeA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 142
ILE A  70
VAL A  74
LEU A  71
VAL A 111
 SAH  A 400 (-4.1A)
None
None
None
None
 0.96A 3w68C-1jqeA:
undetectable		 3w68C-1jqeA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 142
ILE A  70
VAL A  74
LEU A  71
VAL A 111
 SAH  A 400 (-4.1A)
None
None
None
None
 0.99A 3w68D-1jqeA:
undetectable		 3w68D-1jqeA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A  60
GLY A  62
VAL A  88
TYR A 147
VAL A 148
 SAH  A 400 (-3.3A)
SAH  A 400 (-3.2A)
None
QUN  A 500 ( 3.6A)
SAH  A 400 ( 4.8A)
 0.67A 4f84A-1jqeA:
13.6		 4f84A-1jqeA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A  61
TYR A  98
ILE A  59
VAL A 172
PHE A  19
 SAH  A 400 ( 4.1A)
None
None
None
SAH  A 400 (-3.9A)
 1.27A 4fglA-1jqeA:
undetectable
4fglB-1jqeA:
undetectable		 4fglA-1jqeA:
23.38
4fglB-1jqeA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A  60
GLY A  61
GLY A  62
SER A  91
VAL A 148
 SAH  A 400 (-3.3A)
SAH  A 400 ( 4.1A)
SAH  A 400 (-3.2A)
SAH  A 400 (-4.7A)
SAH  A 400 ( 4.8A)
 0.54A 4htfA-1jqeA:
15.8		 4htfA-1jqeA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A  60
GLY A  61
GLY A  62
SER A  91
VAL A 148
 SAH  A 400 (-3.3A)
SAH  A 400 ( 4.1A)
SAH  A 400 (-3.2A)
SAH  A 400 (-4.7A)
SAH  A 400 ( 4.8A)
 0.41A 4htfB-1jqeA:
15.8		 4htfB-1jqeA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 PHE A 243
CYH A 229
ASN A 251
ALA A 254
LEU A 258
 QUN  A 500 (-4.1A)
None
None
None
None
 1.49A 4oadA-1jqeA:
2.5		 4oadA-1jqeA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 11 LEU A  71
ASP A  67
ILE A 171
ILE A  59
ILE A  70
 None
 0.96A 4qgiB-1jqeA:
undetectable		 4qgiB-1jqeA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 ASP A  67
LEU A  23
ARG A  20
 None
 0.96A 5e8qA-1jqeA:
undetectable		 5e8qA-1jqeA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 139
ILE A 151
LEU A 155
PHE A 157
ILE A 170
 None
 0.71A 5mueA-1jqeA:
undetectable		 5mueA-1jqeA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 139
ILE A 151
LEU A 155
PHE A 157
ILE A 170
 None
 0.68A 5mugA-1jqeA:
undetectable		 5mugA-1jqeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 GLY A  64
TRP A 115
VAL A  87
 None
 0.59A 5vuoB-1jqeA:
0.0		 5vuoB-1jqeA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 5 LEU A 244
PHE A 250
LEU A 182
PHE A 271
 None
 1.25A 5xdxP-1jqeA:
undetectable
5xdxW-1jqeA:
0.0		 5xdxP-1jqeA:
19.57
5xdxW-1jqeA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A  71
ASP A  67
ILE A 171
ILE A  59
ILE A  70
 None
 1.03A 6difA-1jqeA:
undetectable		 6difA-1jqeA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A  71
ASP A  67
ILE A 171
ILE A 139
ILE A  70
 None
 1.08A 6difA-1jqeA:
undetectable		 6difA-1jqeA:
13.93