SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jqg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		5 / 12 ILE A 100
ILE A  52
MET A  64
ALA A 301
LEU A  99
 None
 1.12A 1bsxA-1jqgA:
0.0		 1bsxA-1jqgA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		5 / 12 ILE A 100
ILE A  52
MET A  64
ALA A 301
LEU A  99
 None
 1.12A 1bsxB-1jqgA:
0.0		 1bsxB-1jqgA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		5 / 10 LEU A  50
LEU A  22
ILE A  47
PHE A  55
ILE A 182
 None
 1.41A 1i18A-1jqgA:
undetectable
1i18B-1jqgA:
0.0		 1i18A-1jqgA:
12.47
1i18B-1jqgA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		5 / 10 PHE A  55
ILE A 182
LEU A  50
LEU A  22
ILE A  47
 None
 1.43A 1i18A-1jqgA:
0.0
1i18B-1jqgA:
0.0		 1i18A-1jqgA:
12.47
1i18B-1jqgA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		3 / 3 ARG A 302
ILE A 100
TRP A 105
 None
 1.14A 1nodB-1jqgA:
undetectable		 1nodB-1jqgA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		3 / 3 ARG A 302
ILE A 100
TRP A 105
 None
 1.01A 1qomA-1jqgA:
undetectable		 1qomA-1jqgA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		5 / 10 ILE A  52
LEU A  99
LYS A  85
ILE A 297
ILE A 107
 None
 1.26A 1rb3A-1jqgA:
undetectable		 1rb3A-1jqgA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		4 / 6 LEU A 191
PHE A 265
ALA A 263
LEU A 193
 None
 0.90A 1ukbA-1jqgA:
4.4		 1ukbA-1jqgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		5 / 12 GLY A 296
GLY A 300
ASP A 231
ILE A 230
TYR A 238
 None
 0.92A 1x1aA-1jqgA:
undetectable		 1x1aA-1jqgA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		4 / 5 SER A 197
LEU A 280
GLY A 278
ARG A 124
 None
 1.12A 2j2pA-1jqgA:
0.0
2j2pB-1jqgA:
undetectable		 2j2pA-1jqgA:
17.78
2j2pB-1jqgA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		3 / 3 ARG A 302
ILE A 100
TRP A 105
 None
 1.11A 2nodB-1jqgA:
undetectable		 2nodB-1jqgA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		3 / 3 GLU A 270
HIS A  69
GLU A  72
 ZN  A 413 ( 4.9A)
ZN  A 413 (-3.2A)
ZN  A 413 (-2.4A)
 0.77A 2x45B-1jqgA:
0.0		 2x45B-1jqgA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		3 / 3 GLU A 270
HIS A  69
GLU A  72
 ZN  A 413 ( 4.9A)
ZN  A 413 (-3.2A)
ZN  A 413 (-2.4A)
 0.79A 2x45C-1jqgA:
0.0		 2x45C-1jqgA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		5 / 11 ILE A  52
LEU A  99
LYS A  85
ILE A 297
THR A  54
 None
 1.15A 2zzaB-1jqgA:
undetectable		 2zzaB-1jqgA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		5 / 12 THR A  75
ALA A 254
ALA A 111
GLU A  72
THR A 164
 None
None
None
ZN  A 413 (-2.4A)
None
 1.25A 3dl9B-1jqgA:
0.0		 3dl9B-1jqgA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		3 / 3 ARG A 302
ILE A 100
TRP A 105
 None
 1.19A 3e6tB-1jqgA:
0.0		 3e6tB-1jqgA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		3 / 3 ARG A 302
ILE A 100
TRP A 105
 None
 1.06A 3e7iB-1jqgA:
0.0		 3e7iB-1jqgA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		3 / 3 ARG A 302
ILE A 100
TRP A 105
 None
 1.02A 3nw2A-1jqgA:
0.0		 3nw2A-1jqgA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		3 / 3 ARG A 302
ILE A 100
TRP A 105
 None
 1.03A 3nw2B-1jqgA:
undetectable		 3nw2B-1jqgA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		5 / 8 GLY A 296
ALA A 229
ASP A 231
GLY A 223
ILE A 222
 None
 1.31A 3so9A-1jqgA:
undetectable		 3so9A-1jqgA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		4 / 7 VAL A  56
VAL A  26
PHE A  29
ILE A  63
 None
 0.90A 3zjqA-1jqgA:
0.0		 3zjqA-1jqgA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		4 / 7 VAL A  56
VAL A  26
PHE A  29
ILE A  63
 None
 0.92A 3zjqB-1jqgA:
0.0		 3zjqB-1jqgA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		4 / 8 ASP A  36
CYH A  70
GLU A  72
ASP A 123
 None
None
ZN  A 413 (-2.4A)
None
 0.98A 4gkhD-1jqgA:
0.0		 4gkhD-1jqgA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		4 / 8 LEU A 212
SER A 255
VAL A 224
GLY A 223
 None
 0.98A 4klrB-1jqgA:
2.7		 4klrB-1jqgA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		3 / 3 HIS A  13
TRP A  73
SER A   2
 None
 1.18A 4lrhD-1jqgA:
undetectable		 4lrhD-1jqgA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		4 / 6 GLU A 292
THR A 293
THR A 268
HIS A 196
 None
None
None
ZN  A 413 (-3.2A)
 1.30A 4pfjB-1jqgA:
undetectable		 4pfjB-1jqgA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		5 / 11 SER A  39
LEU A  86
VAL A  82
ASP A  90
TRP A  73
 None
 1.44A 4pghC-1jqgA:
undetectable		 4pghC-1jqgA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		4 / 5 SER A  41
GLY A  44
ARG A  45
GLU A  43
 None
 1.26A 4r82A-1jqgA:
0.0
4r82B-1jqgA:
0.0		 4r82A-1jqgA:
17.62
4r82B-1jqgA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		3 / 3 VAL A  36
THR A  34
ARG A  51
 None
 0.77A 5b2sB-1jqgA:
0.0		 5b2sB-1jqgA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		3 / 3 ILE A 297
ILE A 202
MET A  64
 None
 0.66A 5i9yA-1jqgA:
undetectable		 5i9yA-1jqgA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		3 / 3 SER A  14
TYR A  15
TYR A 116
 None
 0.81A 5lakC-1jqgA:
0.0
5lakJ-1jqgA:
undetectable		 5lakC-1jqgA:
21.49
5lakJ-1jqgA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		4 / 5 LEU A  76
LEU A  67
MET A  64
TYR A  81
 None
 1.43A 5uc3A-1jqgA:
0.0		 5uc3A-1jqgA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1jqg CARBOXYPEPTIDASE A
(Helicoverpa
armigera) 		3 / 3 TYR A 125
ARG A  71
THR A 119
 None
 0.92A 5z84J-1jqgA:
0.0		 5z84J-1jqgA:
10.34