SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jqk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 11 ALA A 559
THR A 583
LEU A 183
ASP A 551
LEU A 552
None
1.08A 1b02A-1jqkA:
0.0
1b02A-1jqkA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
4 / 4 THR A 152
LEU A 148
VAL A 145
LEU A 141
None
0.97A 1fbmD-1jqkA:
undetectable
1fbmD-1jqkA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 12 GLU A 283
ILE A 384
ILE A 260
ALA A 289
ARG A 385
None
1.35A 1ki7A-1jqkA:
2.4
1ki7A-1jqkA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 12 GLU A 283
ILE A 293
ILE A 260
ARG A 385
ALA A 389
None
1.44A 1ki7B-1jqkA:
2.9
1ki7B-1jqkA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 12 GLU A 283
ILE A 384
ILE A 260
ALA A 289
ARG A 385
None
1.49A 1ki7B-1jqkA:
2.9
1ki7B-1jqkA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
4 / 7 GLY A 513
ILE A 512
PRO A 243
ILE A 409
None
0.78A 1n49A-1jqkA:
undetectable
1n49A-1jqkA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
4 / 7 GLY A 513
ILE A 512
PRO A 243
ILE A 409
None
0.79A 2aojB-1jqkA:
undetectable
2aojB-1jqkA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 10 THR A  92
ALA A  90
ALA A  94
GLY A 573
ALA A 569
None
None
None
None
UNX  A 802 ( 4.6A)
1.05A 2f16K-1jqkA:
undetectable
2f16L-1jqkA:
undetectable
2f16K-1jqkA:
14.75
2f16L-1jqkA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 10 THR A  92
ALA A  90
ALA A  94
GLY A 573
ALA A 569
None
None
None
None
UNX  A 802 ( 4.6A)
1.05A 2f16Y-1jqkA:
undetectable
2f16Z-1jqkA:
undetectable
2f16Y-1jqkA:
14.75
2f16Z-1jqkA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 12 ALA A 537
LEU A 540
ALA A 541
GLN A 443
ILE A 442
None
1.19A 2jjpA-1jqkA:
undetectable
2jjpA-1jqkA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
3 / 3 HIS A 527
MET A 492
MET A 306
None
1.33A 2vj1A-1jqkA:
0.0
2vj1A-1jqkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
3 / 3 HIS A 527
MET A 492
MET A 307
None
1.17A 2vj1A-1jqkA:
0.0
2vj1A-1jqkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
4 / 7 THR A 479
GLY A 480
HIS A  95
ILE A 572
None
WCC  A 800 ( 4.4A)
None
None
0.87A 2y7wC-1jqkA:
2.9
2y7wC-1jqkA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
4 / 6 LEU A  84
VAL A 591
VAL A 585
VAL A 615
None
0.84A 2z97A-1jqkA:
0.0
2z97A-1jqkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
4 / 8 LEU A  84
VAL A 591
VAL A 585
VAL A 615
None
0.88A 2zujA-1jqkA:
undetectable
2zujA-1jqkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 12 VAL A 262
ALA A 261
ALA A 387
ILE A 339
THR A 301
None
1.29A 3dl9B-1jqkA:
0.0
3dl9B-1jqkA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 12 ILE A 260
ALA A 331
GLN A 353
ALA A 390
LEU A 269
None
1.11A 3dzyA-1jqkA:
undetectable
3dzyA-1jqkA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
4 / 7 GLY A 480
GLY A 450
GLU A 304
ALA A 483
WCC  A 800 ( 4.4A)
WCC  A 800 (-4.1A)
None
None
0.83A 3fpjB-1jqkA:
2.4
3fpjB-1jqkA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
3 / 3 LEU A 214
LEU A 217
ARG A 176
None
0.67A 3hcnB-1jqkA:
3.7
3hcnB-1jqkA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
4 / 8 LEU A 325
THR A 326
GLY A 251
ILE A 298
None
0.79A 3jusB-1jqkA:
0.7
3jusB-1jqkA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 9 ALA A 277
ILE A 260
GLY A 292
ILE A 285
ILE A 384
None
1.05A 3nu4A-1jqkA:
undetectable
3nu4A-1jqkA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 12 GLY A 623
ALA A 622
SER A 460
TYR A 462
PHE A 486
None
1.23A 3s8pA-1jqkA:
undetectable
3s8pA-1jqkA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 12 GLY A 623
ALA A 622
SER A 460
TYR A 462
PHE A 486
None
1.23A 3s8pB-1jqkA:
undetectable
3s8pB-1jqkA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
4 / 7 GLY A 365
ALA A 366
VAL A 334
ILE A 346
None
0.72A 3t3cA-1jqkA:
undetectable
3t3cA-1jqkA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 10 GLY A  73
ALA A  74
GLY A  56
LEU A  48
ILE A  79
None
SF4  A 750 ( 4.0A)
SF4  A 750 ( 3.7A)
None
None
0.93A 3ttpA-1jqkA:
undetectable
3ttpA-1jqkA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
3 / 3 LEU A 104
MET A 106
ASP A 147
None
0.89A 3v5wA-1jqkA:
undetectable
3v5wA-1jqkA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
4 / 6 THR A 315
ASN A 316
CYH A 299
ILE A 339
None
None
WCC  A 800 ( 4.4A)
None
1.21A 3w9tB-1jqkA:
0.0
3w9tB-1jqkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
4 / 6 SER A 234
ASP A 235
ILE A 102
PHE A 238
None
0.99A 4acbC-1jqkA:
undetectable
4acbC-1jqkA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 12 GLY A 623
ALA A 622
SER A 460
TYR A 462
PHE A 486
None
1.22A 4bupA-1jqkA:
undetectable
4bupA-1jqkA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 11 ALA A 571
ASP A 223
SER A 535
THR A 583
VAL A 449
None
1.43A 4kyaE-1jqkA:
undetectable
4kyaE-1jqkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 11 ALA A 571
ASP A 223
SER A 535
THR A 583
VAL A 449
None
1.42A 4kyaG-1jqkA:
undetectable
4kyaG-1jqkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
4 / 8 ASP A 282
VAL A 258
GLY A 288
ALA A 387
None
0.88A 4m48A-1jqkA:
2.1
4m48A-1jqkA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 12 ARG A 100
ALA A 103
ALA A 222
GLY A 226
GLU A  97
None
1.28A 4r29C-1jqkA:
undetectable
4r29C-1jqkA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
4 / 7 LEU A 185
SER A 574
THR A 583
VAL A 609
None
0.98A 4wnvD-1jqkA:
1.8
4wnvD-1jqkA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 11 GLY A 256
ALA A 387
ILE A 260
LEU A 280
ILE A 285
None
1.17A 4xumB-1jqkA:
0.0
4xumB-1jqkA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
4 / 6 VAL A 134
LEU A 229
ILE A 190
PHE A 156
None
0.94A 5jw1A-1jqkA:
0.0
5jw1A-1jqkA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 12 VAL A 410
ALA A 487
SER A 408
GLN A 320
GLY A 297
None
1.24A 5m54E-1jqkA:
4.5
5m54E-1jqkA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 12 VAL A 410
ALA A 487
SER A 408
GLN A 320
GLY A 297
None
1.17A 5m5cB-1jqkA:
undetectable
5m5cB-1jqkA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 10 LEU A 555
GLY A 580
LEU A 544
VAL A 538
ALA A 545
None
1.01A 5o96G-1jqkA:
undetectable
5o96H-1jqkA:
3.9
5o96G-1jqkA:
18.93
5o96H-1jqkA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
4 / 7 ILE A 442
LEU A 475
MET A 526
LEU A 477
None
1.02A 5u4sA-1jqkA:
4.1
5u4sA-1jqkA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 12 ILE A 442
LEU A 469
VAL A 476
LEU A 433
LEU A 421
None
1.24A 6b54A-1jqkA:
2.1
6b54A-1jqkA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum)
5 / 11 ILE A 339
LEU A 343
PRO A 344
THR A 367
MET A 332
None
1.19A 6hupA-1jqkA:
2.7
6hupB-1jqkA:
0.0
6hupA-1jqkA:
8.41
6hupB-1jqkA:
8.35