SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jqp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		6 / 10 GLN A 227
GLY A 231
SER A 232
PHE A 236
HIS A 380
ALA A 381
 None
 0.31A 1stfE-1jqpA:
19.8
1stfI-1jqpA:
undetectable		 1stfE-1jqpA:
19.61
1stfI-1jqpA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		5 / 12 TYR A 315
ALA A 286
GLY A 290
ILE A 281
ILE A 435
 None
 1.18A 1ve3A-1jqpA:
undetectable		 1ve3A-1jqpA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		4 / 7 ALA A   4
TYR A  83
TYR A 234
PHE A  80
 None
 1.13A 2ajvH-1jqpA:
undetectable
2ajvL-1jqpA:
undetectable		 2ajvH-1jqpA:
19.09
2ajvL-1jqpA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		3 / 3 ARG A 225
GLN A 261
PRO A 260
 None
 0.91A 2qhfA-1jqpA:
0.0		 2qhfA-1jqpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		4 / 5 PHE A 113
SER A 267
PHE A  68
ILE A 281
 None
 1.01A 2v0mD-1jqpA:
0.0		 2v0mD-1jqpA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		4 / 5 TYR A 285
ILE A 281
LEU A 242
LEU A 239
 None
 1.13A 2zb7A-1jqpA:
undetectable		 2zb7A-1jqpA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		4 / 7 GLN A 227
GLY A 231
HIS A 380
TRP A 404
 None
 0.35A 3ai8A-1jqpA:
29.6		 3ai8A-1jqpA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		3 / 3 ASN A 109
ASP A 288
GLN A 287
 None
 0.84A 3eeyE-1jqpA:
undetectable		 3eeyE-1jqpA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		5 / 12 PHE A  80
SER A 267
THR A  97
ILE A 281
ALA A 286
 None
 1.19A 3nxuB-1jqpA:
0.0		 3nxuB-1jqpA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		4 / 6 LEU A 242
PRO A 436
GLN A 254
PRO A 256
 None
 1.43A 3vkxA-1jqpA:
0.1		 3vkxA-1jqpA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		4 / 7 GLU A  84
TYR A  93
HIS A  95
VAL A 114
 None
 1.08A 4a97H-1jqpA:
0.0		 4a97H-1jqpA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		3 / 3 ARG A  25
ARG A 108
TRP A 110
 CL  A 503 (-4.5A)
None
None
 1.09A 4cpzC-1jqpA:
undetectable		 4cpzC-1jqpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		3 / 3 ARG A  25
ARG A 108
TRP A 110
 CL  A 503 (-4.5A)
None
None
 1.10A 4cpzE-1jqpA:
undetectable		 4cpzE-1jqpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		3 / 3 ARG A  25
ARG A 108
TRP A 110
 CL  A 503 (-4.5A)
None
None
 1.10A 4cpzH-1jqpA:
undetectable		 4cpzH-1jqpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		5 / 11 VAL A 264
ALA A 304
LEU A 239
VAL A 263
THR A 302
 None
 1.45A 4eilA-1jqpA:
undetectable		 4eilA-1jqpA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		5 / 10 VAL A 264
ALA A 304
LEU A 239
VAL A 263
THR A 302
 None
 1.34A 4eilB-1jqpA:
undetectable		 4eilB-1jqpA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		5 / 11 VAL A 264
ALA A 304
LEU A 239
VAL A 263
THR A 302
 None
 1.45A 4eilC-1jqpA:
undetectable		 4eilC-1jqpA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		4 / 5 LEU A 334
GLU A 426
LEU A 206
HIS A 342
 None
 1.37A 4xi3B-1jqpA:
undetectable		 4xi3B-1jqpA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		5 / 12 ASP A 104
HIS A 103
TYR A  75
HIS A  23
ILE A  28
 None
 1.19A 4ynmB-1jqpA:
undetectable		 4ynmB-1jqpA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		5 / 12 ASP A 104
HIS A 103
TYR A  75
HIS A  23
ILE A  28
 None
 1.22A 4ynpA-1jqpA:
undetectable		 4ynpA-1jqpA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		3 / 3 HIS A 352
ASP A 354
HIS A 365
 SO4  A 504 (-3.9A)
None
SO4  A 504 ( 4.9A)
 0.76A 5n1tW-1jqpA:
undetectable		 5n1tW-1jqpA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1jqp DIPEPTIDYL PEPTIDASE
I
(Rattus
norvegicus) 		4 / 8 LEU A  47
LYS A 371
TYR A   8
LYS A  45
 None
 0.84A 6ce2A-1jqpA:
undetectable		 6ce2A-1jqpA:
14.50