SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jr1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		3 / 3 THR A  52
PRO A  64
THR A  63
 None
 0.96A 1dscC-1jr1A:
undetectable		 1dscC-1jr1A:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 11 LEU A 390
LEU A 377
MET A 386
VAL A 457
ILE A 464
 None
 1.41A 1ee2A-1jr1A:
undetectable		 1ee2A-1jr1A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		4 / 6 VAL A 323
VAL A  66
ILE A 300
MET A  82
 None
 1.14A 1iepA-1jr1A:
undetectable		 1iepA-1jr1A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		4 / 6 ALA A 308
LYS A 311
ASP A 315
ALA A 316
 None
 0.48A 1iwhA-1jr1A:
undetectable		 1iwhA-1jr1A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 12 LEU A 337
GLY A 413
GLY A 415
CYH A 331
THR A 333
 None
IMP  A1331 (-3.5A)
IMP  A1331 ( 3.1A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
 1.11A 1likA-1jr1A:
undetectable		 1likA-1jr1A:
23.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 8 ASP A 274
SER A 275
ASN A 303
GLY A 326
CYH A 331
GLY A 415
 MOA  A1332 (-3.5A)
None
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
IMP  A1331 ( 3.1A)
 0.79A 1me7A-1jr1A:
48.8		 1me7A-1jr1A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 8 ASP A 274
SER A 276
ASN A 303
GLY A 326
CYH A 331
GLY A 415
 MOA  A1332 (-3.5A)
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
IMP  A1331 ( 3.1A)
 0.48A 1me7A-1jr1A:
48.8		 1me7A-1jr1A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 10 ASP A 274
SER A 275
SER A 276
ASN A 303
GLY A 326
GLY A 415
 MOA  A1332 (-3.5A)
None
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 ( 3.1A)
 0.75A 1mehA-1jr1A:
47.1		 1mehA-1jr1A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		4 / 8 ASP A 274
SER A 275
ASN A 303
GLY A 415
 MOA  A1332 (-3.5A)
None
MOA  A1332 (-3.7A)
IMP  A1331 ( 3.1A)
 0.91A 1meiA-1jr1A:
48.3		 1meiA-1jr1A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		4 / 8 ASP A 274
SER A 276
ASN A 303
GLY A 415
 MOA  A1332 (-3.5A)
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
IMP  A1331 ( 3.1A)
 0.40A 1meiA-1jr1A:
48.3		 1meiA-1jr1A:
32.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		4 / 5 GLY A 472
ILE A 471
VAL A  49
SER A 467
 None
 1.18A 1rs7A-1jr1A:
0.0		 1rs7A-1jr1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		4 / 6 GLY A 472
ILE A 471
VAL A  49
SER A 467
 None
 1.05A 1rs7B-1jr1A:
0.0		 1rs7B-1jr1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 8 GLY A  86
GLY A  87
SER A 237
ALA A  83
ILE A  59
 None
 0.97A 1yajC-1jr1A:
undetectable		 1yajC-1jr1A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		4 / 6 LEU A 245
VAL A 323
ILE A 300
MET A  82
 None
 1.14A 2hyyC-1jr1A:
undetectable		 2hyyC-1jr1A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		4 / 6 LEU A 273
VAL A 271
MET A 286
ILE A 287
 None
 0.89A 2piwA-1jr1A:
undetectable		 2piwA-1jr1A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 12 ILE A 362
LEU A 476
ALA A 374
VAL A  66
LEU A  65
LEU A 460
 None
 1.49A 2yqzA-1jr1A:
undetectable		 2yqzA-1jr1A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 12 SER A 276
GLY A 326
GLY A 340
SER A 275
GLY A 324
 MOA  A1332 (-2.6A)
MOA  A1332 ( 3.5A)
None
None
None
 0.94A 3axzA-1jr1A:
0.0		 3axzA-1jr1A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 12 VAL A 347
SER A  53
MET A 386
ILE A 367
VAL A  49
 None
 1.16A 3g8iA-1jr1A:
undetectable		 3g8iA-1jr1A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		3 / 3 SER A 275
GLY A 302
SER A 280
 None
 0.56A 3loqA-1jr1A:
undetectable		 3loqA-1jr1A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		4 / 6 VAL A 323
VAL A  66
ILE A 300
MET A  82
 None
 1.13A 3mssC-1jr1A:
undetectable		 3mssC-1jr1A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 8 GLY A  86
TYR A 233
LYS A 238
SER A 237
GLU A 111
 None
 1.46A 3u9hB-1jr1A:
undetectable		 3u9hB-1jr1A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		4 / 5 ILE A 471
ALA A 473
MET A 482
ARG A 480
 None
 0.97A 4ac9B-1jr1A:
undetectable
4ac9C-1jr1A:
undetectable		 4ac9B-1jr1A:
22.63
4ac9C-1jr1A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		4 / 5 ILE A 471
ALA A 473
MET A 482
ARG A 480
 None
 0.94A 4acaB-1jr1A:
2.0
4acaC-1jr1A:
undetectable		 4acaB-1jr1A:
22.63
4acaC-1jr1A:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 8 ASP A 274
ASN A 303
ARG A 322
MET A 325
GLY A 413
 MOA  A1332 (-3.5A)
MOA  A1332 (-3.7A)
MOA  A1332 (-3.6A)
None
IMP  A1331 (-3.5A)
 0.95A 4af0A-1jr1A:
57.1		 4af0A-1jr1A:
56.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		8 / 8 ASP A 274
SER A 275
SER A 276
ASN A 303
ARG A 322
MET A 325
GLY A 415
GLN A 441
 MOA  A1332 (-3.5A)
None
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 (-3.6A)
None
IMP  A1331 ( 3.1A)
MOA  A1332 ( 3.8A)
 0.52A 4af0A-1jr1A:
57.1		 4af0A-1jr1A:
56.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 8 SER A 276
ASN A 303
MET A 325
GLY A 442
GLN A 441
 MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
None
IMP  A1331 (-3.0A)
MOA  A1332 ( 3.8A)
 1.09A 4af0A-1jr1A:
57.1		 4af0A-1jr1A:
56.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 10 ASP A 274
ASN A 303
ARG A 322
MET A 325
MET A 414
GLY A 413
 MOA  A1332 (-3.5A)
MOA  A1332 (-3.7A)
MOA  A1332 (-3.6A)
None
None
IMP  A1331 (-3.5A)
 1.37A 4af0B-1jr1A:
57.1		 4af0B-1jr1A:
56.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		9 / 10 ASP A 274
SER A 275
SER A 276
ASN A 303
ARG A 322
MET A 325
MET A 414
GLY A 415
GLN A 441
 MOA  A1332 (-3.5A)
None
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 (-3.6A)
None
None
IMP  A1331 ( 3.1A)
MOA  A1332 ( 3.8A)
 0.52A 4af0B-1jr1A:
57.1		 4af0B-1jr1A:
56.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 10 SER A 276
ASN A 303
ARG A 322
MET A 414
GLY A 413
 MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 (-3.6A)
None
IMP  A1331 (-3.5A)
 1.36A 4af0B-1jr1A:
57.1		 4af0B-1jr1A:
56.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 10 SER A 276
ASN A 303
MET A 325
GLY A 442
GLN A 441
 MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
None
IMP  A1331 (-3.0A)
MOA  A1332 ( 3.8A)
 1.10A 4af0B-1jr1A:
57.1		 4af0B-1jr1A:
56.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 8 GLY A  86
TYR A 233
LYS A 238
SER A 237
GLU A 111
 None
 1.48A 4bjcA-1jr1A:
undetectable		 4bjcA-1jr1A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 12 GLY A 365
ALA A 363
THR A 383
ALA A 346
VAL A 347
 IMP  A1331 ( 3.9A)
None
None
None
None
 1.37A 4df3B-1jr1A:
undetectable		 4df3B-1jr1A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		4 / 6 ALA A 320
PRO A 360
LEU A  55
THR A  56
 None
 0.90A 4dtzA-1jr1A:
undetectable		 4dtzA-1jr1A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		4 / 6 ALA A 320
PRO A 360
LEU A  55
THR A  56
 None
 0.90A 4dtzB-1jr1A:
undetectable		 4dtzB-1jr1A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		4 / 7 ALA A 320
PRO A 360
LEU A  55
THR A  56
 None
 0.85A 4du2B-1jr1A:
0.0		 4du2B-1jr1A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 10 GLN A 309
VAL A 304
LEU A 321
VAL A 323
VAL A 361
 None
 0.96A 4e3hA-1jr1A:
undetectable		 4e3hA-1jr1A:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		7 / 8 ASP A 274
SER A 275
SER A 276
ASN A 303
THR A 333
MET A 414
GLY A 415
 MOA  A1332 (-3.5A)
None
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 (-3.0A)
None
IMP  A1331 ( 3.1A)
 1.14A 4fo4A-1jr1A:
51.1		 4fo4A-1jr1A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		7 / 8 SER A 275
SER A 276
ASN A 303
CYH A 331
THR A 333
MET A 414
GLY A 415
 None
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
None
IMP  A1331 ( 3.1A)
 0.81A 4fo4A-1jr1A:
51.1		 4fo4A-1jr1A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 8 SER A 275
ASN A 303
GLY A 326
CYH A 331
THR A 333
GLY A 415
 None
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
IMP  A1331 ( 3.1A)
 0.74A 4fo4B-1jr1A:
50.8		 4fo4B-1jr1A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 8 SER A 275
ASN A 303
GLY A 326
THR A 333
MET A 414
GLY A 415
 None
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
MOA  A1332 (-3.0A)
None
IMP  A1331 ( 3.1A)
 0.69A 4fo4B-1jr1A:
50.8		 4fo4B-1jr1A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 8 SER A 276
ASN A 303
GLY A 326
CYH A 331
THR A 333
GLY A 415
 MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
IMP  A1331 ( 3.1A)
 0.53A 4fo4B-1jr1A:
50.8		 4fo4B-1jr1A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 8 SER A 276
ASN A 303
GLY A 326
THR A 333
MET A 414
GLY A 415
 MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
MOA  A1332 (-3.0A)
None
IMP  A1331 ( 3.1A)
 0.46A 4fo4B-1jr1A:
50.8		 4fo4B-1jr1A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 9 ASP A 274
SER A 275
GLY A 326
CYH A 331
THR A 333
 MOA  A1332 (-3.5A)
None
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
 1.12A 4fxsA-1jr1A:
53.2		 4fxsA-1jr1A:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 9 ASP A 274
SER A 276
GLY A 326
CYH A 331
THR A 333
 MOA  A1332 (-3.5A)
MOA  A1332 (-2.6A)
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
 0.93A 4fxsA-1jr1A:
53.2		 4fxsA-1jr1A:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 9 SER A 275
ASN A 303
GLY A 326
CYH A 331
THR A 333
ASP A 364
 None
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
IMP  A1331 (-2.8A)
 0.76A 4fxsA-1jr1A:
53.2		 4fxsA-1jr1A:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 9 SER A 276
ASN A 303
GLY A 326
CYH A 331
THR A 333
ASP A 364
 MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
IMP  A1331 (-2.8A)
 0.63A 4fxsA-1jr1A:
53.2		 4fxsA-1jr1A:
38.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 12 ALA A 248
MET A 290
VAL A 271
ALA A 264
ASP A 261
 None
 1.07A 4qrcA-1jr1A:
undetectable		 4qrcA-1jr1A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 12 SER A 276
GLY A 326
GLY A 340
SER A 275
GLY A 324
 MOA  A1332 (-2.6A)
MOA  A1332 ( 3.5A)
None
None
None
 0.99A 4yvgA-1jr1A:
undetectable		 4yvgA-1jr1A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 10 VAL A 323
ALA A 381
SER A 351
THR A  63
PRO A 360
 None
 1.44A 5mm4B-1jr1A:
0.7		 5mm4B-1jr1A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 12 LEU A 377
ALA A 381
SER A 351
THR A  52
PRO A 360
 None
 1.22A 5nd3B-1jr1A:
undetectable		 5nd3B-1jr1A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 11 LEU A 389
ILE A 367
GLY A 366
GLY A 328
LEU A 390
 None
None
IMP  A1331 (-3.7A)
IMP  A1331 ( 3.0A)
None
 0.92A 5twjD-1jr1A:
undetectable		 5twjD-1jr1A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		3 / 3 ILE A 367
VAL A 384
PRO A  64
 None
 0.63A 5uunA-1jr1A:
undetectable		 5uunA-1jr1A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		4 / 6 ALA A 266
LYS A 109
GLN A 243
ASP A 239
 None
 1.44A 5y9aA-1jr1A:
undetectable		 5y9aA-1jr1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		3 / 3 TYR A 258
ALA A 264
LEU A 265
 None
 0.67A 6ag0C-1jr1A:
6.6		 6ag0C-1jr1A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 12 ASP A  71
ASP A 256
HIS A  93
SER A  68
GLY A 415
 None
None
None
IMP  A1331 (-2.6A)
IMP  A1331 ( 3.1A)
 1.16A 6b0lB-1jr1A:
3.0		 6b0lB-1jr1A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		3 / 3 GLY A 451
THR A 394
GLU A 395
 None
 0.66A 6b58A-1jr1A:
undetectable		 6b58A-1jr1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 12 LEU A 273
VAL A 350
ARG A 322
VAL A 323
ASP A 364
 None
None
MOA  A1332 (-3.6A)
None
IMP  A1331 (-2.8A)
 1.39A 6bxlB-1jr1A:
undetectable		 6bxlB-1jr1A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 12 GLY A 413
GLY A 415
GLY A 398
ASN A  94
ARG A 412
 IMP  A1331 (-3.5A)
IMP  A1331 ( 3.1A)
None
None
None
 1.07A 6gngB-1jr1A:
undetectable		 6gngB-1jr1A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		4 / 7 VAL A 323
ILE A 300
MET A  82
GLY A  86
 None
 0.85A 6hd6B-1jr1A:
undetectable		 6hd6B-1jr1A:
8.54