SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jr2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LWC_A_NVPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	1jr2	UROPORPHYRINOGEN-III SYNTHASE (Homo sapiens)	5 / 11	PRO A 142 LEU A 59 VAL A 107 GLY A 111 LEU A 50	None	1.27A	1lwcA-1jr2A: undetectable	1lwcA-1jr2A: 17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PIW_A_T3A932_1 (ANDROGEN RECEPTOR)	1jr2	UROPORPHYRINOGEN-III SYNTHASE (Homo sapiens)	4 / 6	LEU A 6 VAL A 35 ILE A 176 ILE A 208	None	0.88A	2piwA-1jr2A: undetectable	2piwA-1jr2A: 19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YVP_A_GBMA402_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1)	1jr2	UROPORPHYRINOGEN-III SYNTHASE (Homo sapiens)	5 / 11	LEU A 74 TRP A 83 ILE A 110 LEU A 140 LEU A 59	None	1.17A	4yvpA-1jr2A: undetectable	4yvpA-1jr2A: 22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YVP_B_GBMB402_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1)	1jr2	UROPORPHYRINOGEN-III SYNTHASE (Homo sapiens)	5 / 12	LEU A 74 TRP A 83 ILE A 110 LEU A 140 LEU A 59	None	1.22A	4yvpB-1jr2A: undetectable	4yvpB-1jr2A: 22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HBM_A_NVPA601_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1jr2	UROPORPHYRINOGEN-III SYNTHASE (Homo sapiens)	5 / 11	PRO A 142 LEU A 59 VAL A 107 GLY A 111 LEU A 50	None	1.23A	5hbmA-1jr2A: undetectable	5hbmA-1jr2A: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A4I_A_TRPA403_0 (TRYPTOPHAN 2,3-DIOXYGENASE)	1jr2	UROPORPHYRINOGEN-III SYNTHASE (Homo sapiens)	4 / 8	ARG A 230 THR A 228 PRO A 198 ILE A 224	None	0.99A	6a4iA-1jr2A: undetectable	6a4iA-1jr2A: 24.38

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1LWC_A_NVPA999_1","HIV-1 REVERSE TRANSCRIPTASE","1jr2","UROPORPHYRINOGEN-III SYNTHASE","Homo sapiens",5,"PRO A 142;LEU A  59;VAL A 107;GLY A 111;LEU A  50","None","1.27A","1lwcA-1jr2A:undetectable","1lwcA-1jr2A:17.86"],["2PIW_A_T3A932_1","ANDROGEN RECEPTOR","1jr2","UROPORPHYRINOGEN-III SYNTHASE","Homo sapiens",4,"LEU A   6;VAL A  35;ILE A 176;ILE A 208","None","0.88A","2piwA-1jr2A:undetectable","2piwA-1jr2A:19.59"],["4YVP_A_GBMA402_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1","1jr2","UROPORPHYRINOGEN-III SYNTHASE","Homo sapiens",5,"LEU A  74;TRP A  83;ILE A 110;LEU A 140;LEU A  59","None","1.17A","4yvpA-1jr2A:undetectable","4yvpA-1jr2A:22.57"],["4YVP_B_GBMB402_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1","1jr2","UROPORPHYRINOGEN-III SYNTHASE","Homo sapiens",5,"LEU A  74;TRP A  83;ILE A 110;LEU A 140;LEU A  59","None","1.22A","4yvpB-1jr2A:undetectable","4yvpB-1jr2A:22.57"],["5HBM_A_NVPA601_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1jr2","UROPORPHYRINOGEN-III SYNTHASE","Homo sapiens",5,"PRO A 142;LEU A  59;VAL A 107;GLY A 111;LEU A  50","None","1.23A","5hbmA-1jr2A:undetectable","5hbmA-1jr2A:19.67"],["6A4I_A_TRPA403_0","TRYPTOPHAN 2,3-DIOXYGENASE","1jr2","UROPORPHYRINOGEN-III SYNTHASE","Homo sapiens",4,"ARG A 230;THR A 228;PRO A 198;ILE A 224","None","0.99A","6a4iA-1jr2A:undetectable","6a4iA-1jr2A:24.38"]]