SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jr7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		5 / 11 MET A 157
HIS A 160
ASP A 162
HIS A 292
ARG A 305
 None
FE2  A 501 (-3.9A)
FE2  A 501 (-2.7A)
FE2  A 501 (-3.9A)
None
 0.86A 1uofA-1jr7A:
4.8		 1uofA-1jr7A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		5 / 11 PHE A 297
MET A 157
HIS A 160
HIS A 292
ARG A 305
 None
None
FE2  A 501 (-3.9A)
FE2  A 501 (-3.9A)
None
 1.49A 1uofA-1jr7A:
4.8		 1uofA-1jr7A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		5 / 9 LEU A 193
HIS A 205
ALA A 208
GLU A 255
LEU A 259
 None
 1.42A 2azqA-1jr7A:
0.0		 2azqA-1jr7A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		5 / 12 LEU A  95
LEU A 174
GLN A 310
LEU A 121
THR A  86
 None
 1.26A 2oaxA-1jr7A:
undetectable		 2oaxA-1jr7A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		4 / 5 ILE A 122
LEU A  83
ALA A 119
PHE A  37
 None
 0.92A 2opxA-1jr7A:
undetectable		 2opxA-1jr7A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		4 / 8 MET A 308
LEU A 174
SER A 131
VAL A  54
 None
 1.01A 2qd2A-1jr7A:
undetectable		 2qd2A-1jr7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		5 / 11 ALA A  99
ILE A  97
MET A 176
ALA A 115
VAL A 118
 None
 1.02A 2qhfA-1jr7A:
undetectable		 2qhfA-1jr7A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		4 / 6 LEU A 207
PHE A 214
ASP A 225
GLU A 255
 None
 1.23A 2vn1B-1jr7A:
0.0		 2vn1B-1jr7A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		5 / 11 ARG A 294
TYR A 165
ALA A 129
MET A 157
LEU A 150
 None
 1.43A 3jwqA-1jr7A:
undetectable
3jwqD-1jr7A:
undetectable		 3jwqA-1jr7A:
21.63
3jwqD-1jr7A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		3 / 3 ASN A 286
ASP A 171
ARG A 209
 None
 0.91A 3k13C-1jr7A:
0.5		 3k13C-1jr7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		3 / 4 SER A  26
GLY A 271
GLU A 267
 None
 0.67A 3raeA-1jr7A:
0.0
3raeC-1jr7A:
1.1		 3raeA-1jr7A:
18.81
3raeC-1jr7A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		5 / 12 PHE A  37
LEU A  87
ILE A 122
TYR A 172
ALA A 115
 None
 1.42A 4a83A-1jr7A:
undetectable		 4a83A-1jr7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		3 / 3 GLU A 110
ASP A 109
ASP A 104
 None
 0.76A 4gc9A-1jr7A:
undetectable		 4gc9A-1jr7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		3 / 4 SER A  26
GLY A 271
GLU A 267
 None
 0.62A 4juoA-1jr7A:
0.0
4juoC-1jr7A:
undetectable		 4juoA-1jr7A:
18.81
4juoC-1jr7A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		4 / 6 ARG A 242
ASP A 162
ARG A 311
GLY A 312
 None
FE2  A 501 (-2.7A)
None
None
 0.97A 5cdqA-1jr7A:
undetectable
5cdqC-1jr7A:
undetectable
5cdqD-1jr7A:
undetectable		 5cdqA-1jr7A:
20.61
5cdqC-1jr7A:
20.61
5cdqD-1jr7A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		5 / 8 ARG A 242
TYR A 243
ILE A 266
ASP A 194
LEU A 193
 None
 1.18A 5nooD-1jr7A:
undetectable		 5nooD-1jr7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		4 / 6 LEU A 283
VAL A 173
LEU A 190
GLU A  92
 None
 0.99A 5tudD-1jr7A:
undetectable		 5tudD-1jr7A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		5 / 12 PHE A  37
LEU A 121
ILE A 122
PHE A  21
LEU A 284
 None
 1.32A 5uanB-1jr7A:
undetectable		 5uanB-1jr7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		4 / 5 HIS A 160
ASP A 162
HIS A 292
ARG A 311
 FE2  A 501 (-3.9A)
FE2  A 501 (-2.7A)
FE2  A 501 (-3.9A)
None
 0.88A 6dchA-1jr7A:
18.5		 6dchA-1jr7A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		5 / 6 ALA A 136
SER A 125
GLY A 312
THR A 170
PHE A 247
 None
 1.47A 6f8cA-1jr7A:
undetectable		 6f8cA-1jr7A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION
(Escherichia
coli) 		5 / 9 LEU A 262
SER A 263
GLU A 267
LEU A 191
ASN A 161
 None
 1.09A 6ftpA-1jr7A:
0.0
6ftpB-1jr7A:
undetectable		 6ftpA-1jr7A:
12.86
6ftpB-1jr7A:
8.97