SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jro'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		4 / 7 ILE A  78
PRO A 108
PHE A 105
ALA A  46
 None
None
None
FES  A3002 ( 4.9A)
 1.08A 1oniD-1jroA:
undetectable
1oniE-1jroA:
undetectable		 1oniD-1jroA:
15.95
1oniE-1jroA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		4 / 5 GLY A 205
ILE A 202
TRP A 211
VAL A 212
 FAD  A3005 (-3.3A)
None
None
None
 1.06A 1rs7A-1jroA:
undetectable		 1rs7A-1jroA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		4 / 6 GLY A 205
ILE A 202
TRP A 211
VAL A 212
 FAD  A3005 (-3.3A)
None
None
None
 1.05A 1rs7B-1jroA:
undetectable		 1rs7B-1jroA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		4 / 4 ASP A 161
LEU A   7
LEU A  75
LEU A   6
 None
 1.34A 1u18A-1jroA:
0.0		 1u18A-1jroA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		5 / 11 ALA A 262
ALA A 303
GLY A 302
ALA A 300
CYH A 367
 None
 1.16A 2f16H-1jroA:
undetectable
2f16I-1jroA:
undetectable		 2f16H-1jroA:
19.61
2f16I-1jroA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		5 / 11 ALA A 262
ALA A 303
GLY A 302
ALA A 300
CYH A 367
 None
 1.19A 2f16V-1jroA:
undetectable
2f16W-1jroA:
undetectable		 2f16V-1jroA:
19.61
2f16W-1jroA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		5 / 8 GLU A  79
LEU A  27
LEU A  26
VAL A  14
ILE A   3
 None
 1.31A 2uxpA-1jroA:
undetectable		 2uxpA-1jroA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		5 / 12 ALA A 443
PHE A 422
VAL A 364
GLY A 385
PRO A 424
 None
 1.18A 2ve3B-1jroA:
1.4		 2ve3B-1jroA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		5 / 12 ALA A 443
PHE A 422
VAL A 364
GLY A 386
PRO A 424
 None
 1.27A 2ve3B-1jroA:
1.4		 2ve3B-1jroA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		5 / 11 ILE A  51
ALA A  62
LEU A  27
LEU A  67
ILE A  70
 None
 0.98A 2w9sA-1jroA:
undetectable		 2w9sA-1jroA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		5 / 11 ILE A  51
ALA A  62
LEU A  27
LEU A  67
ILE A  70
 None
 0.96A 2w9sB-1jroA:
undetectable		 2w9sB-1jroA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		5 / 10 ILE A  51
ALA A  62
LEU A  27
LEU A  67
ILE A  70
 None
 1.04A 2w9sD-1jroA:
undetectable		 2w9sD-1jroA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		5 / 10 ILE A  51
ALA A  62
LEU A  27
LEU A  67
ILE A  70
 None
 1.06A 2w9sF-1jroA:
undetectable		 2w9sF-1jroA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		4 / 8 PHE A 384
ALA A 439
ALA A 443
LEU A 401
 None
 1.04A 2wx2B-1jroA:
undetectable		 2wx2B-1jroA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		5 / 8 LEU A  23
ILE A  70
LEU A  75
THR A  77
LEU A  27
 None
 1.46A 2xfhA-1jroA:
undetectable		 2xfhA-1jroA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		5 / 11 LEU A 252
ALA A 264
ALA A 256
VAL A 247
MET A 301
 None
 1.29A 3bszE-1jroA:
0.0		 3bszE-1jroA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		5 / 11 ALA A 262
ALA A 303
GLY A 302
ALA A 300
CYH A 367
 None
 1.14A 3mg0V-1jroA:
undetectable
3mg0W-1jroA:
undetectable		 3mg0V-1jroA:
19.61
3mg0W-1jroA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		5 / 11 ILE A 382
ALA A 395
ASP A 421
PHE A 397
LEU A 401
 None
 1.04A 3qg2B-1jroA:
undetectable		 3qg2B-1jroA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		3 / 3 PHE A 224
SER A 226
GLN A  69
 None
 1.00A 3smtA-1jroA:
0.0		 3smtA-1jroA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		4 / 5 GLY A 205
ILE A 202
TRP A 211
VAL A 212
 FAD  A3005 (-3.3A)
None
None
None
 1.12A 4d33B-1jroA:
0.0		 4d33B-1jroA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		4 / 6 GLY A 205
ILE A 202
TRP A 211
VAL A 212
 FAD  A3005 (-3.3A)
None
None
None
 1.09A 4d39B-1jroA:
undetectable		 4d39B-1jroA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		3 / 3 ARG A  58
TYR A 125
ASN A 132
 None
 0.81A 4ffwB-1jroA:
undetectable		 4ffwB-1jroA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		4 / 6 GLY A 205
ILE A 202
TRP A 211
VAL A 212
 FAD  A3005 (-3.3A)
None
None
None
 1.07A 4kcnA-1jroA:
undetectable		 4kcnA-1jroA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		5 / 12 ILE A 402
ALA A 395
THR A 410
ILE A 411
ILE A 377
 None
 1.02A 4kjjA-1jroA:
undetectable		 4kjjA-1jroA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		4 / 6 LEU A 210
ASP A  43
VAL A 278
ALA A 279
 None
FAD  A3005 (-3.7A)
None
FAD  A3005 (-3.6A)
 0.98A 4nkxA-1jroA:
0.0		 4nkxA-1jroA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		5 / 12 LEU A 129
MET A  50
ALA A 115
VAL A  91
ILE A  81
 None
 1.16A 4x1kD-1jroA:
undetectable		 4x1kD-1jroA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		5 / 10 MET A 301
LEU A 298
PRO A 259
LEU A 263
GLY A 282
 None
None
None
None
FAD  A3005 ( 4.6A)
 1.30A 4zp0A-1jroA:
0.0		 4zp0A-1jroA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		4 / 8 ILE A 411
ALA A 443
ILE A 382
ALA A 380
 None
 0.67A 5mvmA-1jroA:
0.0
5mvmB-1jroA:
0.0		 5mvmA-1jroA:
10.80
5mvmB-1jroA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 1jro XANTHINE
DEHYDROGENASE, CHAIN
A
(Rhodobacter
capsulatus) 		5 / 12 PHE A 384
ALA A 439
ALA A 443
LEU A 401
ILE A 402
 None
 1.23A 6aybA-1jroA:
undetectable		 6aybA-1jroA:
21.60