SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1js1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		3 / 3 TRP X 256
ARG X 178
THR X 257
 None
 0.91A 1df7A-1js1X:
0.0		 1df7A-1js1X:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		3 / 3 HIS X 319
ASP X 105
ASN X  64
 None
 0.78A 1wg8B-1js1X:
4.7		 1wg8B-1js1X:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		5 / 10 ALA X  16
SER X  20
LEU X  17
PHE X   4
LEU X 155
 None
 1.47A 1y7iB-1js1X:
2.5		 1y7iB-1js1X:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		5 / 10 ALA X  16
SER X  20
LEU X  17
TRP X 191
PHE X   4
 None
 1.31A 1y7iB-1js1X:
2.5		 1y7iB-1js1X:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		4 / 6 LEU X 155
ALA X  16
ASP X 196
TYR X 197
 None
 1.17A 2dpzA-1js1X:
undetectable		 2dpzA-1js1X:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		4 / 5 ARG X 110
PHE X  43
THR X  50
LEU X  52
 PO4  X 501 (-3.0A)
None
PO4  X 501 (-4.2A)
None
 1.22A 2e1qD-1js1X:
0.0		 2e1qD-1js1X:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		5 / 12 ARG X  27
ILE X 304
ASN X 301
TYR X 161
GLU X 160
 None
 1.23A 2f10A-1js1X:
undetectable		 2f10A-1js1X:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		5 / 12 ILE X 304
ARG X  27
ASN X 301
TYR X 161
GLU X 160
 None
 1.39A 2f10A-1js1X:
undetectable		 2f10A-1js1X:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		5 / 12 LEU X  17
PHE X  21
LEU X 155
PRO X 167
VAL X 169
 None
 1.38A 2qd4B-1js1X:
2.9		 2qd4B-1js1X:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		5 / 12 SER X 140
VAL X 109
ILE X 126
PHE X 130
HIS X 133
 None
 1.23A 2vdyA-1js1X:
0.0		 2vdyA-1js1X:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		5 / 12 LEU X 313
ILE X 107
ILE X 106
MET X 141
PHE X 139
 None
 1.03A 2ygoA-1js1X:
undetectable		 2ygoA-1js1X:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		4 / 8 GLY X 229
ALA X 230
ASP X 231
THR X 172
 None
 0.68A 3el0A-1js1X:
undetectable		 3el0A-1js1X:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		3 / 3 LYS X 212
ILE X 131
PHE X 130
 None
 0.75A 3j7zS-1js1X:
0.0
3j7za-1js1X:
undetectable		 3j7zS-1js1X:
15.92
3j7za-1js1X:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		4 / 8 GLY X 229
ALA X 230
ASP X 231
THR X 202
 None
 0.47A 4eyrB-1js1X:
undetectable		 4eyrB-1js1X:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		3 / 3 GLU X 208
TRP X 173
ASN X 245
 None
 0.91A 5dv4A-1js1X:
undetectable		 5dv4A-1js1X:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		3 / 3 MET X  85
HIS X  92
GLY X  82
 None
 0.78A 5gwzB-1js1X:
0.0		 5gwzB-1js1X:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		5 / 12 LEU X  40
ILE X 126
VAL X 109
GLY X 108
ILE X 107
 None
 0.79A 5j2tC-1js1X:
undetectable		 5j2tC-1js1X:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		4 / 8 VAL X  65
LEU X 310
THR X 307
ALA X 306
 None
 0.92A 5tt3H-1js1X:
undetectable		 5tt3H-1js1X:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 1js1 TRANSCARBAMYLASE
(Bacteroides
fragilis) 		3 / 3 TRP X 191
MET X 192
ASN X 193
 None
 1.49A 5uc1A-1js1X:
0.0		 5uc1A-1js1X:
15.62