SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1js4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 8 GLY A 552
GLY A 551
TRP A 128
HIS A 376
 None
 0.78A 1dbbH-1js4A:
3.0
1dbbL-1js4A:
2.9		 1dbbH-1js4A:
17.28
1dbbL-1js4A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 4 THR A 227
LEU A 223
LEU A 216
GLN A 213
 None
 1.15A 1fbmA-1js4A:
undetectable		 1fbmA-1js4A:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		5 / 11 LEU A  49
ALA A 204
ALA A 202
HIS A 125
ARG A 138
 None
 1.34A 1iiuA-1js4A:
0.1		 1iiuA-1js4A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 8 VAL A  60
ARG A 317
GLU A 424
ASP A  58
 None
BGC  A6003 (-2.7A)
None
None
 1.12A 1s3zA-1js4A:
undetectable
1s3zB-1js4A:
undetectable		 1s3zA-1js4A:
13.85
1s3zB-1js4A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.45A 1v54A-1js4A:
0.0
1v54C-1js4A:
1.5		 1v54A-1js4A:
22.63
1v54C-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.46A 1v54N-1js4A:
0.8
1v54P-1js4A:
1.6		 1v54N-1js4A:
22.63
1v54P-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.45A 1v55A-1js4A:
0.0
1v55C-1js4A:
1.5		 1v55A-1js4A:
22.63
1v55C-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_1
(HYPOTHETICAL PROTEIN
PH0226)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 4 TYR A 429
ARG A 317
ASP A  58
ASP A 120
 None
BGC  A6003 (-2.7A)
None
None
 1.39A 1ve3A-1js4A:
0.0		 1ve3A-1js4A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_1
(HYPOTHETICAL PROTEIN
PH0226)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 4 TYR A 429
ARG A 317
ASP A  58
ASP A 120
 None
BGC  A6003 (-2.7A)
None
None
 1.42A 1ve3B-1js4A:
undetectable		 1ve3B-1js4A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 5 ALA A 182
TYR A 186
ALA A 226
TYR A 232
 None
 1.09A 1xl6A-1js4A:
0.7
1xl6B-1js4A:
3.3		 1xl6A-1js4A:
19.28
1xl6B-1js4A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		3 / 3 GLN A  20
HIS A 377
ARG A 378
 None
 0.81A 1zlqA-1js4A:
undetectable		 1zlqA-1js4A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 8 ASP A 151
GLY A  63
TYR A 206
THR A 427
 None
 1.05A 2aouA-1js4A:
undetectable		 2aouA-1js4A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		3 / 3 ASP A 170
ILE A  78
VAL A 179
 None
 0.63A 2avvD-1js4A:
undetectable		 2avvD-1js4A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.45A 2dyrA-1js4A:
2.1
2dyrC-1js4A:
1.5		 2dyrA-1js4A:
22.63
2dyrC-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.47A 2dyrN-1js4A:
0.0
2dyrP-1js4A:
1.6		 2dyrN-1js4A:
22.63
2dyrP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.44A 2dysA-1js4A:
2.3
2dysC-1js4A:
1.6		 2dysA-1js4A:
22.63
2dysC-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 377
THR A 427
TYR A 429
HIS A  59
 None
 1.47A 2dysA-1js4A:
2.3
2dysC-1js4A:
1.6		 2dysA-1js4A:
22.63
2dysC-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.45A 2dysN-1js4A:
2.3
2dysP-1js4A:
1.5		 2dysN-1js4A:
22.63
2dysP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 377
THR A 427
TYR A 429
HIS A  59
 None
 1.46A 2dysN-1js4A:
2.3
2dysP-1js4A:
1.5		 2dysN-1js4A:
22.63
2dysP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.47A 2eijA-1js4A:
2.2
2eijC-1js4A:
1.5		 2eijA-1js4A:
22.63
2eijC-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 377
THR A 427
TYR A 429
HIS A  59
 None
 1.47A 2eijA-1js4A:
2.2
2eijC-1js4A:
1.5		 2eijA-1js4A:
22.63
2eijC-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.48A 2eijN-1js4A:
0.0
2eijP-1js4A:
1.7		 2eijN-1js4A:
22.63
2eijP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.47A 2eikA-1js4A:
undetectable
2eikC-1js4A:
1.5		 2eikA-1js4A:
22.63
2eikC-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.48A 2eikN-1js4A:
2.2
2eikP-1js4A:
1.7		 2eikN-1js4A:
22.63
2eikP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.44A 2eilA-1js4A:
1.8
2eilC-1js4A:
1.5		 2eilA-1js4A:
22.63
2eilC-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 377
THR A 427
TYR A 429
HIS A  59
 None
 1.46A 2eilA-1js4A:
1.8
2eilC-1js4A:
1.5		 2eilA-1js4A:
22.63
2eilC-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.46A 2eilN-1js4A:
0.2
2eilP-1js4A:
1.6		 2eilN-1js4A:
22.63
2eilP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.44A 2eimA-1js4A:
2.8
2eimC-1js4A:
1.6		 2eimA-1js4A:
22.63
2eimC-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.50A 2eimN-1js4A:
2.8
2eimP-1js4A:
1.6		 2eimN-1js4A:
22.63
2eimP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 377
THR A 427
TYR A 429
HIS A  59
 None
 1.40A 2eimN-1js4A:
2.8
2eimP-1js4A:
1.6		 2eimN-1js4A:
22.63
2eimP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.42A 2einA-1js4A:
0.0
2einC-1js4A:
1.6		 2einA-1js4A:
22.63
2einC-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 377
THR A 427
TYR A 429
HIS A  59
 None
 1.38A 2einA-1js4A:
0.0
2einC-1js4A:
1.6		 2einA-1js4A:
22.63
2einC-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.47A 2einN-1js4A:
1.8
2einP-1js4A:
1.5		 2einN-1js4A:
22.63
2einP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 VAL A 364
SER A 362
LEU A 437
PHE A   4
 None
 1.27A 2f8dA-1js4A:
undetectable		 2f8dA-1js4A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 4 ALA A 182
TYR A 186
ALA A 226
TYR A 232
 None
 1.11A 2wlkA-1js4A:
3.5
2wlkB-1js4A:
3.2		 2wlkA-1js4A:
19.28
2wlkB-1js4A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		3 / 3 MET A 482
VAL A 539
GLU A 478
 None
 0.84A 2x9gA-1js4A:
undetectable		 2x9gA-1js4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.45A 2y69A-1js4A:
0.0
2y69C-1js4A:
1.6		 2y69A-1js4A:
22.63
2y69C-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		5 / 12 GLY A  51
THR A  50
GLY A  38
ASN A  96
PRO A  26
 None
 1.04A 2y7hB-1js4A:
undetectable		 2y7hB-1js4A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.44A 2zxwA-1js4A:
2.2
2zxwC-1js4A:
1.6		 2zxwA-1js4A:
22.63
2zxwC-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 377
THR A 427
TYR A 429
HIS A  59
 None
 1.47A 2zxwA-1js4A:
2.2
2zxwC-1js4A:
1.6		 2zxwA-1js4A:
22.63
2zxwC-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.45A 2zxwN-1js4A:
1.2
2zxwP-1js4A:
1.5		 2zxwN-1js4A:
22.63
2zxwP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.45A 3abkA-1js4A:
2.2
3abkC-1js4A:
1.5		 3abkA-1js4A:
22.63
3abkC-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.45A 3abkN-1js4A:
2.4
3abkP-1js4A:
1.7		 3abkN-1js4A:
22.63
3abkP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.45A 3abmN-1js4A:
2.1
3abmP-1js4A:
1.5		 3abmN-1js4A:
22.63
3abmP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 377
THR A 427
TYR A 429
HIS A  59
 None
 1.45A 3abmN-1js4A:
2.1
3abmP-1js4A:
1.5		 3abmN-1js4A:
22.63
3abmP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.49A 3ag1A-1js4A:
0.0
3ag1C-1js4A:
1.7		 3ag1A-1js4A:
22.63
3ag1C-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.47A 3ag1N-1js4A:
0.0
3ag1P-1js4A:
1.7		 3ag1N-1js4A:
22.63
3ag1P-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.48A 3ag2A-1js4A:
2.2
3ag2C-1js4A:
1.6		 3ag2A-1js4A:
22.63
3ag2C-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.49A 3ag2N-1js4A:
2.4
3ag2P-1js4A:
1.6		 3ag2N-1js4A:
22.63
3ag2P-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.46A 3ag3A-1js4A:
2.5
3ag3C-1js4A:
1.5		 3ag3A-1js4A:
22.63
3ag3C-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.45A 3ag3N-1js4A:
2.3
3ag3P-1js4A:
1.6		 3ag3N-1js4A:
22.63
3ag3P-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 377
THR A 427
TYR A 429
HIS A  59
 None
 1.49A 3ag3N-1js4A:
2.3
3ag3P-1js4A:
1.6		 3ag3N-1js4A:
22.63
3ag3P-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.47A 3ag4A-1js4A:
0.2
3ag4C-1js4A:
1.5		 3ag4A-1js4A:
22.63
3ag4C-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 377
THR A 427
TYR A 429
HIS A  59
 None
 1.48A 3ag4A-1js4A:
0.2
3ag4C-1js4A:
1.5		 3ag4A-1js4A:
22.63
3ag4C-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.49A 3ag4N-1js4A:
2.2
3ag4P-1js4A:
1.7		 3ag4N-1js4A:
22.63
3ag4P-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.45A 3asnA-1js4A:
0.0
3asnC-1js4A:
1.5		 3asnA-1js4A:
22.63
3asnC-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		5 / 12 VAL A 364
GLY A 400
ALA A 431
GLY A 432
LEU A 437
 None
 0.83A 3ku1A-1js4A:
undetectable		 3ku1A-1js4A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		5 / 12 VAL A 364
GLY A 400
ALA A 431
GLY A 432
LEU A 437
 None
 0.82A 3ku1C-1js4A:
undetectable		 3ku1C-1js4A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		5 / 12 GLY A  63
VAL A  60
ALA A  56
ALA A 426
GLU A 424
 None
 0.95A 3mteB-1js4A:
undetectable		 3mteB-1js4A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		5 / 12 PHE A 499
ILE A 581
PHE A 578
ALA A 586
ILE A 479
 None
 1.13A 3ndiA-1js4A:
undetectable		 3ndiA-1js4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		5 / 10 ALA A  70
LEU A  93
ASN A  96
LEU A  97
VAL A 100
 None
 0.36A 3o02A-1js4A:
0.0
3o02B-1js4A:
2.0		 3o02A-1js4A:
19.08
3o02B-1js4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		3 / 3 GLN A 468
GLU A 559
LYS A 480
 None
 1.17A 3su9A-1js4A:
undetectable		 3su9A-1js4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		3 / 3 PHE A   4
TYR A 352
LEU A  10
 None
 0.62A 3sueB-1js4A:
undetectable		 3sueB-1js4A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 5 TYR A 399
PHE A 452
PRO A 454
LEU A 449
 None
 1.18A 3tgvC-1js4A:
0.0		 3tgvC-1js4A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		3 / 3 PHE A 578
VAL A 509
ILE A 514
 None
 0.59A 4emaA-1js4A:
0.3		 4emaA-1js4A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 8 ASN A 423
ASP A 416
ASP A 415
VAL A 365
 None
 0.80A 4f8hA-1js4A:
0.3
4f8hB-1js4A:
0.1		 4f8hA-1js4A:
20.91
4f8hB-1js4A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 8 ASN A 423
ASP A 416
ASP A 415
VAL A 365
 None
 0.89A 4f8hB-1js4A:
0.1
4f8hC-1js4A:
0.3		 4f8hB-1js4A:
20.91
4f8hC-1js4A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 8 ASN A 423
ASP A 416
ASP A 415
VAL A 365
 None
 0.83A 4f8hC-1js4A:
0.3
4f8hD-1js4A:
0.4		 4f8hC-1js4A:
20.91
4f8hD-1js4A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 8 ASN A 423
ASP A 416
ASP A 415
VAL A 365
 None
 0.81A 4f8hD-1js4A:
0.4
4f8hE-1js4A:
0.4		 4f8hD-1js4A:
20.91
4f8hE-1js4A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 8 VAL A 365
ASN A 423
ASP A 416
ASP A 415
 None
 0.84A 4f8hA-1js4A:
0.3
4f8hE-1js4A:
0.4		 4f8hA-1js4A:
20.91
4f8hE-1js4A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		3 / 3 ARG A 492
GLU A 462
ASN A 485
 None
 0.88A 4imaD-1js4A:
undetectable		 4imaD-1js4A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 8 LEU A 178
ASN A 101
ASP A 102
ILE A 105
 None
 1.06A 4k0bA-1js4A:
undetectable		 4k0bA-1js4A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 8 LEU A 178
ASN A 101
ASP A 102
ILE A 105
 None
 1.06A 4l7iA-1js4A:
0.0		 4l7iA-1js4A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		3 / 3 GLY A 460
PRO A 461
GLN A 486
 None
 0.57A 4oltB-1js4A:
0.0		 4oltB-1js4A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 5 THR A 427
THR A  69
ASP A 428
TYR A 206
 None
None
BGC  A6003 ( 4.5A)
None
 1.43A 4oltB-1js4A:
0.0		 4oltB-1js4A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 ALA A   9
ILE A 350
LEU A 402
PHE A 433
 None
 1.12A 4uymB-1js4A:
0.0		 4uymB-1js4A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		3 / 3 LEU A  97
ASP A 102
ILE A 165
 None
 0.71A 4xi3D-1js4A:
undetectable		 4xi3D-1js4A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.45A 5b1aN-1js4A:
2.2
5b1aP-1js4A:
1.6		 5b1aN-1js4A:
22.63
5b1aP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.46A 5b1bN-1js4A:
0.0
5b1bP-1js4A:
1.6		 5b1bN-1js4A:
22.63
5b1bP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.47A 5b3sN-1js4A:
0.2
5b3sP-1js4A:
1.6		 5b3sN-1js4A:
22.63
5b3sP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 ASP A 419
TYR A 363
TYR A 429
LEU A 402
 None
 1.35A 5bmvB-1js4A:
undetectable		 5bmvB-1js4A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 ASN A 423
VAL A 403
ALA A 401
GLY A 366
 None
 0.95A 5fpdA-1js4A:
undetectable		 5fpdA-1js4A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.41A 5iy5A-1js4A:
0.0
5iy5C-1js4A:
1.5		 5iy5A-1js4A:
22.63
5iy5C-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		5 / 12 GLU A 137
ASP A  44
GLY A  42
ASN A  40
LEU A  39
 None
 1.34A 5kbwA-1js4A:
0.0		 5kbwA-1js4A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 LEU A 251
TRP A 287
ALA A 284
LEU A 288
 None
 1.11A 5nwvA-1js4A:
0.0		 5nwvA-1js4A:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 LEU A  10
ASN A 430
VAL A 364
GLU A  18
 None
 1.08A 5tudA-1js4A:
2.3		 5tudA-1js4A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.47A 5x19N-1js4A:
0.8
5x19P-1js4A:
1.7		 5x19N-1js4A:
22.63
5x19P-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.44A 5x1bN-1js4A:
2.1
5x1bP-1js4A:
1.8		 5x1bN-1js4A:
22.63
5x1bP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.47A 5x1fN-1js4A:
0.1
5x1fP-1js4A:
1.7		 5x1fN-1js4A:
22.63
5x1fP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.45A 5zcqN-1js4A:
2.2
5zcqP-1js4A:
1.6		 5zcqN-1js4A:
22.63
5zcqP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		5 / 12 TYR A  84
PHE A 324
GLY A  83
ALA A 438
LEU A  10
 None
 1.21A 5zwrA-1js4A:
0.0		 5zwrA-1js4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.48A 6nknA-1js4A:
1.7
6nknC-1js4A:
1.6		 6nknA-1js4A:
22.63
6nknC-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.49A 6nmfN-1js4A:
2.1
6nmfP-1js4A:
1.6		 6nmfN-1js4A:
22.63
6nmfP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 377
THR A 427
TYR A 429
HIS A  59
 None
 1.46A 6nmfN-1js4A:
2.1
6nmfP-1js4A:
1.6		 6nmfN-1js4A:
22.63
6nmfP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.45A 6nmpA-1js4A:
2.2
6nmpC-1js4A:
1.6		 6nmpA-1js4A:
22.63
6nmpC-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 6 HIS A 377
THR A 427
TYR A 429
HIS A  59
 None
 1.39A 6nmpA-1js4A:
2.2
6nmpC-1js4A:
1.6		 6nmpA-1js4A:
22.63
6nmpC-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 108
ASP A 190
TYR A 192
HIS A 181
 None
 1.49A 6nmpN-1js4A:
0.8
6nmpP-1js4A:
1.7		 6nmpN-1js4A:
22.63
6nmpP-1js4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js4 ENDO/EXOCELLULASE E4
(Thermobifida
fusca) 		4 / 7 HIS A 377
THR A 427
TYR A 429
HIS A  59
 None
 1.42A 6nmpN-1js4A:
0.8
6nmpP-1js4A:
1.7		 6nmpN-1js4A:
22.63
6nmpP-1js4A:
17.74