SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1js6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		5 / 12 ALA A 313
LEU A 122
LEU A 305
LEU A 406
ALA A 272
 None
 1.05A 1bzfA-1js6A:
undetectable		 1bzfA-1js6A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		5 / 12 ALA A 278
ILE A 378
LEU A 122
LEU A 126
PHE A 297
 None
 1.19A 1dtlA-1js6A:
undetectable		 1dtlA-1js6A:
15.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JS3_A_142A701_1
(DOPA DECARBOXYLASE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		7 / 9 TRP A  71
TYR A  79
PHE A  80
THR A  82
HIS A 192
THR A 246
HIS A 302
 None
None
PLP  A 601 (-4.7A)
None
PLP  A 601 (-3.4A)
PLP  A 601 (-4.3A)
PLP  A 601 (-4.2A)
 0.29A 1js3A-1js6A:
67.4
1js3B-1js6A:
67.4		 1js3A-1js6A:
100.00
1js3B-1js6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JS3_A_142A701_1
(DOPA DECARBOXYLASE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		7 / 9 TRP A  71
TYR A  79
PHE A  80
THR A  82
HIS A 192
THR A 246
LYS A 303
 None
None
PLP  A 601 (-4.7A)
None
PLP  A 601 (-3.4A)
PLP  A 601 (-4.3A)
PLP  A 601 (-1.2A)
 0.59A 1js3A-1js6A:
67.4
1js3B-1js6A:
67.4		 1js3A-1js6A:
100.00
1js3B-1js6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JS3_B_142B702_1
(DOPA DECARBOXYLASE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		7 / 9 TRP A  71
TYR A  79
PHE A  80
THR A  82
HIS A 192
THR A 246
HIS A 302
 None
None
PLP  A 601 (-4.7A)
None
PLP  A 601 (-3.4A)
PLP  A 601 (-4.3A)
PLP  A 601 (-4.2A)
 0.30A 1js3A-1js6A:
67.4
1js3B-1js6A:
67.4		 1js3A-1js6A:
100.00
1js3B-1js6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JS3_B_142B702_1
(DOPA DECARBOXYLASE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		7 / 9 TRP A  71
TYR A  79
PHE A  80
THR A  82
HIS A 192
THR A 246
LYS A 303
 None
None
PLP  A 601 (-4.7A)
None
PLP  A 601 (-3.4A)
PLP  A 601 (-4.3A)
PLP  A 601 (-1.2A)
 0.60A 1js3A-1js6A:
67.4
1js3B-1js6A:
67.4		 1js3A-1js6A:
100.00
1js3B-1js6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 6 TRP A 464
GLU A 465
ARG A 397
ILE A 467
 None
 1.19A 1nsiA-1js6A:
0.3
1nsiB-1js6A:
0.6		 1nsiA-1js6A:
21.05
1nsiB-1js6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		5 / 12 ALA A 131
GLU A 130
GLN A 127
ASN A 289
LEU A 288
 None
 1.25A 1u72A-1js6A:
2.5		 1u72A-1js6A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 8 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.91A 1v54P-1js6A:
undetectable
1v54W-1js6A:
0.0		 1v54P-1js6A:
19.84
1v54W-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		5 / 12 ALA A 185
GLY A 203
GLY A 202
LEU A 156
LEU A 157
 None
 0.89A 1ya4A-1js6A:
2.3		 1ya4A-1js6A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 8 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.89A 2eikP-1js6A:
undetectable
2eikW-1js6A:
0.0		 2eikP-1js6A:
19.84
2eikW-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 8 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.91A 2eilP-1js6A:
undetectable
2eilW-1js6A:
undetectable		 2eilP-1js6A:
19.84
2eilW-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 7 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.93A 2eimP-1js6A:
undetectable
2eimW-1js6A:
0.0		 2eimP-1js6A:
19.84
2eimW-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2001_1
(SERUM ALBUMIN)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		5 / 12 LEU A 424
ILE A 467
HIS A 466
ARG A 426
GLY A 469
 None
 1.34A 2vufA-1js6A:
0.0		 2vufA-1js6A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 7 GLY A 341
THR A 112
ARG A 319
LEU A 342
 None
 1.01A 2xrhA-1js6A:
undetectable		 2xrhA-1js6A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 6 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 1.01A 3abkP-1js6A:
undetectable
3abkW-1js6A:
0.0		 3abkP-1js6A:
19.84
3abkW-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 7 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.99A 3ag2P-1js6A:
undetectable
3ag2W-1js6A:
0.0		 3ag2P-1js6A:
19.84
3ag2W-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 7 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.92A 3ag4P-1js6A:
undetectable
3ag4W-1js6A:
0.0		 3ag4P-1js6A:
19.84
3ag4W-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 7 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.94A 3asnP-1js6A:
undetectable
3asnW-1js6A:
0.0		 3asnP-1js6A:
19.84
3asnW-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 8 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.97A 3asoC-1js6A:
undetectable
3asoJ-1js6A:
undetectable		 3asoC-1js6A:
19.84
3asoJ-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 7 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.93A 3asoP-1js6A:
undetectable
3asoW-1js6A:
0.0		 3asoP-1js6A:
19.84
3asoW-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		3 / 3 GLY A 140
GLY A 135
GLY A 138
 None
 0.41A 3bogC-1js6A:
undetectable		 3bogC-1js6A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 8 TRP A 464
GLU A 465
ARG A 397
ILE A 467
 None
 1.20A 3e7gC-1js6A:
0.8
3e7gD-1js6A:
0.6		 3e7gC-1js6A:
20.81
3e7gD-1js6A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 6 VAL A 195
ILE A 260
ALA A 185
LEU A 206
 None
 0.71A 3kk6B-1js6A:
undetectable		 3kk6B-1js6A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 8 LEU A  94
LEU A 114
ARG A 356
ILE A  98
 None
 0.95A 3ln1A-1js6A:
undetectable		 3ln1A-1js6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 7 LEU A  94
LEU A 114
ARG A 356
ILE A  98
 None
 0.94A 3ln1B-1js6A:
0.0		 3ln1B-1js6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 8 ASP A 189
SER A 188
SER A 250
CYH A 438
 None
 1.04A 3m0wE-1js6A:
undetectable
3m0wF-1js6A:
undetectable
3m0wG-1js6A:
undetectable
3m0wH-1js6A:
undetectable		 3m0wE-1js6A:
11.27
3m0wF-1js6A:
11.27
3m0wG-1js6A:
11.27
3m0wH-1js6A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		5 / 12 LEU A 180
VAL A 204
LEU A 167
ILE A 235
ALA A 159
 None
 0.92A 3mdvB-1js6A:
0.0		 3mdvB-1js6A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 5 LEU A 153
ALA A 155
PHE A 238
ASN A 298
 None
 1.42A 3uq6A-1js6A:
undetectable		 3uq6A-1js6A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 4 LEU A 153
ALA A 155
PHE A 238
ASN A 298
 None
 1.37A 3vaqA-1js6A:
3.9		 3vaqA-1js6A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 4 LEU A 153
ALA A 155
PHE A 238
ASN A 298
 None
 1.37A 3vasA-1js6A:
undetectable		 3vasA-1js6A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 6 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.98A 3wg7P-1js6A:
0.0
3wg7W-1js6A:
undetectable		 3wg7P-1js6A:
19.84
3wg7W-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 8 ARG A 397
ILE A 467
TRP A 464
GLU A 465
 None
 1.16A 4cx7A-1js6A:
0.4
4cx7B-1js6A:
0.3		 4cx7A-1js6A:
21.05
4cx7B-1js6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 8 TRP A 464
GLU A 465
ARG A 397
ILE A 467
 None
 1.19A 4cx7A-1js6A:
0.2
4cx7B-1js6A:
0.3		 4cx7A-1js6A:
21.05
4cx7B-1js6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		3 / 3 TYR A  30
HIS A 434
ARG A 431
 None
 0.99A 4e7bC-1js6A:
0.0		 4e7bC-1js6A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 7 ARG A 356
GLY A  96
ILE A  98
MET A  17
 None
 1.07A 4g0vA-1js6A:
1.3		 4g0vA-1js6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 7 TRP A 464
GLU A 465
ARG A 397
ILE A 467
 None
 1.21A 4nosA-1js6A:
0.4
4nosB-1js6A:
0.3		 4nosA-1js6A:
20.50
4nosB-1js6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 7 ARG A 397
ILE A 467
TRP A 464
GLU A 465
 None
 1.23A 4nosC-1js6A:
0.3
4nosD-1js6A:
0.3		 4nosC-1js6A:
20.50
4nosD-1js6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		3 / 3 PRO A  87
MET A  89
TYR A  86
 None
 0.85A 4qa2B-1js6A:
4.1		 4qa2B-1js6A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		5 / 12 ALA A 148
SER A 277
ARG A 285
LEU A 128
THR A 152
 PLP  A 601 (-3.4A)
None
None
None
None
 1.08A 4qi9A-1js6A:
2.3		 4qi9A-1js6A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		5 / 12 ALA A 148
SER A 277
ARG A 285
LEU A 128
THR A 152
 PLP  A 601 (-3.4A)
None
None
None
None
 1.14A 4qi9B-1js6A:
2.2		 4qi9B-1js6A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 6 ASP A 271
ALA A 275
THR A 242
THR A 245
 PLP  A 601 (-2.9A)
None
PLP  A 601 ( 4.6A)
None
 1.46A 4w5qA-1js6A:
2.8		 4w5qA-1js6A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 6 ASP A 271
ALA A 275
THR A 242
THR A 245
 PLP  A 601 (-2.9A)
None
PLP  A 601 ( 4.6A)
None
 1.47A 4w5tA-1js6A:
2.1		 4w5tA-1js6A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 6 ASP A 271
ALA A 275
THR A 242
THR A 245
 PLP  A 601 (-2.9A)
None
PLP  A 601 ( 4.6A)
None
 1.46A 4z4fA-1js6A:
2.1		 4z4fA-1js6A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 5 ASP A 271
ALA A 275
THR A 242
THR A 245
 PLP  A 601 (-2.9A)
None
PLP  A 601 ( 4.6A)
None
 1.47A 4z4gA-1js6A:
undetectable		 4z4gA-1js6A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 5 ALA A 151
HIS A  72
PRO A 301
PHE A 309
 None
 1.25A 4ze2A-1js6A:
0.0		 4ze2A-1js6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 7 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.96A 5b1aC-1js6A:
undetectable
5b1aJ-1js6A:
0.0		 5b1aC-1js6A:
19.84
5b1aJ-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 7 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.92A 5b1aP-1js6A:
undetectable
5b1aW-1js6A:
0.0		 5b1aP-1js6A:
19.84
5b1aW-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 7 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.88A 5b1bP-1js6A:
undetectable
5b1bW-1js6A:
0.0		 5b1bP-1js6A:
19.84
5b1bW-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		5 / 12 ALA A 148
SER A 277
ARG A 285
LEU A 128
THR A 152
 PLP  A 601 (-3.4A)
None
None
None
None
 1.05A 5hi6A-1js6A:
2.1		 5hi6A-1js6A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		3 / 3 VAL A 392
ARG A 439
PRO A 437
 None
 0.80A 5koxA-1js6A:
undetectable		 5koxA-1js6A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 5 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.97A 5x19C-1js6A:
undetectable
5x19J-1js6A:
0.0		 5x19C-1js6A:
19.84
5x19J-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 5 HIS A 302
ALA A 148
SER A 312
GLY A 146
 PLP  A 601 (-4.2A)
PLP  A 601 (-3.4A)
None
None
 1.26A 5yodD-1js6A:
undetectable		 5yodD-1js6A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 7 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.89A 5z84C-1js6A:
0.0
5z84J-1js6A:
0.0		 5z84C-1js6A:
19.84
5z84J-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 7 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.89A 5z85C-1js6A:
undetectable
5z85J-1js6A:
0.0		 5z85C-1js6A:
19.84
5z85J-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 7 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.91A 5zcoC-1js6A:
undetectable
5zcoJ-1js6A:
0.0		 5zcoC-1js6A:
19.84
5zcoJ-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 7 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.89A 5zcqC-1js6A:
undetectable
5zcqJ-1js6A:
0.0		 5zcqC-1js6A:
19.84
5zcqJ-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 7 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.88A 5zcqP-1js6A:
undetectable
5zcqW-1js6A:
0.0		 5zcqP-1js6A:
19.84
5zcqW-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1js6 DOPA DECARBOXYLASE
(Sus
scrofa) 		4 / 4 GLY A 290
ARG A 285
ASN A 289
LEU A 254
 None
 1.24A 6b58A-1js6A:
0.0		 6b58A-1js6A:
21.36