SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jsc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 111
VAL A 159
ILE A 182
GLY A 143
 None
 0.95A 11gsA-1jscA:
0.0		 11gsA-1jscA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 356
ASN A 361
GLY A 353
VAL A 303
 FAD  A 701 (-4.6A)
None
FAD  A 701 (-3.5A)
None
 0.92A 1dbbH-1jscA:
undetectable
1dbbL-1jscA:
undetectable		 1dbbH-1jscA:
17.69
1dbbL-1jscA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 335
THR A 334
THR A 518
THR A 495
VAL A 493
 FAD  A 701 (-4.1A)
FAD  A 701 (-2.8A)
None
None
None
 1.06A 1pkvA-1jscA:
undetectable
1pkvB-1jscA:
0.0		 1pkvA-1jscA:
10.12
1pkvB-1jscA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 493
LEU A 335
THR A 334
THR A 518
THR A 495
 None
FAD  A 701 (-4.1A)
FAD  A 701 (-2.8A)
None
None
 1.04A 1pkvA-1jscA:
undetectable
1pkvB-1jscA:
undetectable		 1pkvA-1jscA:
10.12
1pkvB-1jscA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 325
PRO A 302
ASP A 368
ALA A 299
ILE A 296
 None
 1.43A 1s14B-1jscA:
undetectable		 1s14B-1jscA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 SER A 324
ILE A 421
ALA A 372
LEU A 304
ILE A 370
 None
 1.13A 1uduA-1jscA:
undetectable		 1uduA-1jscA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 10 ASN A  99
GLY A  95
THR A 254
ILE A 118
LEU A 160
 None
 1.09A 1z11C-1jscA:
0.0		 1z11C-1jscA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 111
VAL A 159
ILE A 182
GLY A 143
 None
 0.92A 2gssA-1jscA:
undetectable		 2gssA-1jscA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 111
VAL A 159
ILE A 182
GLY A 143
 None
 0.92A 2gssB-1jscA:
undetectable		 2gssB-1jscA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 496
SER A 552
GLY A 526
HIS A 144
GLN A 140
 None
TPP  A 700 (-2.8A)
None
None
None
 1.20A 2hmaA-1jscA:
undetectable		 2hmaA-1jscA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 107
PHE A 234
ILE A 230
LEU A 226
VAL A 185
 None
 1.28A 2jn3A-1jscA:
undetectable		 2jn3A-1jscA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 477
LEU A 480
ASP A 546
ALA A 504
 None
 0.91A 2opxA-1jscA:
undetectable		 2opxA-1jscA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 162
ILE A 118
GLY A 115
TYR A 122
PHE A 133
 2HP  A 698 ( 4.1A)
None
2HP  A 698 (-3.6A)
None
None
 1.45A 2y7kA-1jscA:
0.8		 2y7kA-1jscA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 10 THR A 162
ILE A 118
GLY A 115
TYR A 122
PHE A 133
 2HP  A 698 ( 4.1A)
None
2HP  A 698 (-3.6A)
None
None
 1.44A 2y7kB-1jscA:
0.6		 2y7kB-1jscA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 10 THR A 162
ILE A 118
GLY A 115
TYR A 122
PHE A 133
 2HP  A 698 ( 4.1A)
None
2HP  A 698 (-3.6A)
None
None
 1.47A 2y7pA-1jscA:
0.8		 2y7pA-1jscA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 125
MET A 102
PHE A  98
PHE A 234
VAL A 220
 None
 1.01A 2ygqA-1jscA:
undetectable		 2ygqA-1jscA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 374
GLU A 407
SER A 409
ASP A 426
ALA A 427
 FAD  A 701 (-3.5A)
FAD  A 701 (-2.9A)
FAD  A 701 ( 3.9A)
FAD  A 701 (-3.8A)
FAD  A 701 (-3.5A)
 1.14A 3id6C-1jscA:
0.9		 3id6C-1jscA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.15A 3mg02-1jscA:
undetectable
3mg0V-1jscA:
undetectable		 3mg02-1jscA:
16.75
3mg0V-1jscA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.15A 3mg0N-1jscA:
undetectable		 3mg0N-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 111
VAL A 159
ILE A 182
GLY A 143
 None
 0.87A 3n9jA-1jscA:
undetectable		 3n9jA-1jscA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 374
GLU A 407
SER A 409
ASP A 426
ALA A 427
 FAD  A 701 (-3.5A)
FAD  A 701 (-2.9A)
FAD  A 701 ( 3.9A)
FAD  A 701 (-3.8A)
FAD  A 701 (-3.5A)
 1.07A 3nmuA-1jscA:
0.0
3nmuF-1jscA:
undetectable		 3nmuA-1jscA:
20.82
3nmuF-1jscA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 GLN A 501
GLY A 520
ASP A 176
ALA A 531
ALA A 532
 None
FAD  A 701 ( 4.4A)
None
None
None
 1.11A 3sufC-1jscA:
undetectable		 3sufC-1jscA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 534
GLY A 157
ALA A 150
ALA A 177
ASP A 180
 None
 1.07A 3sugA-1jscA:
undetectable		 3sugA-1jscA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 493
GLY A 157
ALA A 150
ALA A 177
ASP A 180
 None
 1.04A 3sugA-1jscA:
undetectable		 3sugA-1jscA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 533
GLY A 534
VAL A 564
THR A 568
GLY A 567
 None
 1.32A 4acaB-1jscA:
undetectable
4acaC-1jscA:
3.0		 4acaB-1jscA:
22.78
4acaC-1jscA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 504
GLY A 549
ILE A 547
ASP A 550
GLU A 578
 None
TPP  A 700 (-3.6A)
None
MG  A 699 ( 2.8A)
None
 1.03A 4dcmA-1jscA:
3.7		 4dcmA-1jscA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 403
ALA A 392
ALA A 389
ILE A 385
VAL A 417
 None
 1.16A 4h1nA-1jscA:
0.0		 4h1nA-1jscA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 230
LEU A 226
ILE A 125
GLY A 189
 None
 0.80A 4hb8A-1jscA:
undetectable		 4hb8A-1jscA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 THR A 518
THR A 495
HIS A 355
LEU A 335
 None
None
FAD  A 701 (-3.9A)
FAD  A 701 (-4.1A)
 0.97A 4pgfA-1jscA:
3.6		 4pgfA-1jscA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.08A 4qvlV-1jscA:
undetectable
4qvlb-1jscA:
undetectable		 4qvlV-1jscA:
17.64
4qvlb-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.08A 4qvlH-1jscA:
undetectable
4qvlN-1jscA:
undetectable		 4qvlH-1jscA:
17.64
4qvlN-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.08A 4qvmV-1jscA:
undetectable
4qvmb-1jscA:
undetectable		 4qvmV-1jscA:
17.64
4qvmb-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.08A 4qvmH-1jscA:
undetectable
4qvmN-1jscA:
undetectable		 4qvmH-1jscA:
17.64
4qvmN-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.08A 4qvwV-1jscA:
undetectable
4qvwb-1jscA:
undetectable		 4qvwV-1jscA:
17.64
4qvwb-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.08A 4qvwH-1jscA:
undetectable
4qvwN-1jscA:
undetectable		 4qvwH-1jscA:
17.64
4qvwN-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.07A 4qw0V-1jscA:
undetectable
4qw0b-1jscA:
undetectable		 4qw0V-1jscA:
17.64
4qw0b-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.07A 4qw0H-1jscA:
undetectable
4qw0N-1jscA:
undetectable		 4qw0H-1jscA:
17.64
4qw0N-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.08A 4qw3V-1jscA:
undetectable
4qw3b-1jscA:
undetectable		 4qw3V-1jscA:
17.64
4qw3b-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.08A 4qw3H-1jscA:
undetectable
4qw3N-1jscA:
undetectable		 4qw3H-1jscA:
17.64
4qw3N-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 389
VAL A 364
LEU A 320
ALA A 372
PHE A 377
 None
 0.87A 4v04B-1jscA:
undetectable		 4v04B-1jscA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.07A 5cz7H-1jscA:
undetectable
5cz7N-1jscA:
undetectable		 5cz7H-1jscA:
17.64
5cz7N-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.07A 5d0xV-1jscA:
undetectable
5d0xb-1jscA:
undetectable		 5d0xV-1jscA:
17.64
5d0xb-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.07A 5d0xH-1jscA:
undetectable
5d0xN-1jscA:
undetectable		 5d0xH-1jscA:
17.64
5d0xN-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 427
ASN A 430
LEU A 431
 FAD  A 701 (-3.5A)
None
None
 0.49A 5i1nC-1jscA:
undetectable		 5i1nC-1jscA:
7.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 115
GLY A 116
GLN A 202
 2HP  A 698 (-3.6A)
2HP  A 698 (-3.5A)
2HP  A 698 ( 3.2A)
 0.12A 5imsA-1jscA:
61.4		 5imsA-1jscA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 116
GLN A 202
LYS A 251
 2HP  A 698 (-3.5A)
2HP  A 698 ( 3.2A)
None
 0.38A 5imsB-1jscA:
57.9		 5imsB-1jscA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.08A 5l5zV-1jscA:
undetectable
5l5zb-1jscA:
undetectable		 5l5zV-1jscA:
17.64
5l5zb-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.08A 5l5zH-1jscA:
undetectable
5l5zN-1jscA:
undetectable		 5l5zH-1jscA:
17.64
5l5zN-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.09A 5l66V-1jscA:
undetectable
5l66b-1jscA:
undetectable		 5l66V-1jscA:
17.64
5l66b-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.09A 5l66H-1jscA:
undetectable
5l66N-1jscA:
undetectable		 5l66H-1jscA:
17.64
5l66N-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 352
GLY A 337
VAL A 331
LEU A 349
ALA A 360
 None
 1.01A 5o96C-1jscA:
2.1
5o96D-1jscA:
2.7		 5o96C-1jscA:
16.29
5o96D-1jscA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 352
GLY A 337
VAL A 331
LEU A 349
ALA A 360
 None
 0.96A 5o96E-1jscA:
2.7
5o96F-1jscA:
undetectable		 5o96E-1jscA:
16.29
5o96F-1jscA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 625
ILE A 471
TYR A 462
 None
 0.57A 5uunB-1jscA:
0.0		 5uunB-1jscA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 329
LEU A 320
PHE A 377
ALA A 375
GLY A 309
 None
None
None
FAD  A 701 (-3.8A)
FAD  A 701 (-3.4A)
 1.11A 5uxdB-1jscA:
0.0		 5uxdB-1jscA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 GLU A 407
SER A 409
ASP A 426
ALA A 427
ASN A 312
 FAD  A 701 (-2.9A)
FAD  A 701 ( 3.9A)
FAD  A 701 (-3.8A)
FAD  A 701 (-3.5A)
FAD  A 701 (-4.0A)
 0.96A 5x6yA-1jscA:
2.6		 5x6yA-1jscA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 150
GLY A 148
GLY A 534
ASN A 312
 None
None
None
FAD  A 701 (-4.0A)
 0.78A 5ybbB-1jscA:
undetectable		 5ybbB-1jscA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 500
GLY A 498
LEU A 529
GLY A 526
SER A 552
 TPP  A 700 (-3.9A)
TPP  A 700 (-3.3A)
None
None
TPP  A 700 (-2.8A)
 1.13A 6c2mA-1jscA:
undetectable		 6c2mA-1jscA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 563
GLY A 528
THR A 494
ILE A 492
 None
 0.90A 6f8cA-1jscA:
undetectable		 6f8cA-1jscA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.03A 6hwdV-1jscA:
undetectable
6hwdb-1jscA:
undetectable		 6hwdV-1jscA:
10.96
6hwdb-1jscA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.04A 6hwdH-1jscA:
undetectable
6hwdN-1jscA:
undetectable		 6hwdH-1jscA:
10.96
6hwdN-1jscA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 173
GLY A 523
GLY A 526
GLY A 496
ALA A 531
 None
TPP  A 700 (-4.9A)
None
None
None
 1.03A 6nj9K-1jscA:
3.6		 6nj9K-1jscA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 THR A 214
GLU A 232
ASN A 217
 None
 0.78A 6nj9K-1jscA:
3.6		 6nj9K-1jscA:
20.62