SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jsd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 7 LEU A 184
THR A 145
LEU A 241
GLY A 239
 None
 0.90A 1gtiB-1jsdA:
0.0		 1gtiB-1jsdA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 6 LEU A 144
VAL A 226
VAL A 194
ILE A 116
 None
 1.03A 2hyyB-1jsdA:
undetectable		 2hyyB-1jsdA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 7 ASN A  38
GLY A 277
THR A 274
MET A  40
 None
 1.01A 2o5yH-1jsdA:
undetectable
2o5yL-1jsdA:
undetectable		 2o5yH-1jsdA:
20.25
2o5yL-1jsdA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 1jsd HAEMAGGLUTININ (HA2
CHAIN)
(Influenza
A
virus) 		3 / 3 ASP B 133
PHE B 138
LEU B 140
 None
 0.71A 2zi9A-1jsdB:
undetectable		 2zi9A-1jsdB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 6 THR A 261
ILE A  51
SER A 265
LEU A  41
 None
 0.88A 3deuB-1jsdA:
undetectable		 3deuB-1jsdA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 6 LEU A 144
VAL A 226
VAL A 194
ILE A 116
 None
 1.08A 3k5vA-1jsdA:
undetectable		 3k5vA-1jsdA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 6 LEU A 144
VAL A 226
VAL A 194
ILE A 116
 None
 1.02A 3k5vB-1jsdA:
undetectable		 3k5vB-1jsdA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		5 / 12 ALA A 156
GLN A 157
LEU A 233
ILE A 172
LEU A 144
 NAG  A 321 ( 4.3A)
None
None
None
None
 0.86A 3oapA-1jsdA:
undetectable		 3oapA-1jsdA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 5 GLU A 275
LEU A 263
HIS A  37
GLY A  39
 None
 1.27A 3pp1A-1jsdA:
undetectable		 3pp1A-1jsdA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 7 LEU A 184
TYR A 185
ILE A 242
GLY A 128
 None
 0.86A 4eq4A-1jsdA:
undetectable		 4eq4A-1jsdA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 7 LEU A 184
TYR A 185
ILE A 242
GLY A 128
 None
 0.87A 4eqlA-1jsdA:
undetectable		 4eqlA-1jsdA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 7 LEU A 184
TYR A 185
ILE A 242
GLY A 128
 None
 0.88A 4eqlB-1jsdA:
undetectable		 4eqlB-1jsdA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		5 / 12 LEU A 233
VAL A 235
PRO A 244
HIS A 248
GLY A  63
 None
 1.23A 4hvcB-1jsdA:
undetectable		 4hvcB-1jsdA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 1jsd HAEMAGGLUTININ (HA2
CHAIN)
(Influenza
A
virus) 		5 / 12 GLY B   4
ILE B   6
ALA B   7
ALA B 113
ASP B 109
 None
 1.23A 4kicA-1jsdB:
undetectable		 4kicA-1jsdB:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
HAEMAGGLUTININ (HA2
CHAIN)
(Influenza
A
virus;
Influenza
A
virus) 		4 / 8 LEU A  32
LEU A 305
LYS B  51
ILE B  55
 None
 0.77A 4klaA-1jsdA:
undetectable		 4klaA-1jsdA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 6 LEU A 184
TYR A 185
ILE A 242
GLY A 128
 None
 0.89A 4l39A-1jsdA:
0.0		 4l39A-1jsdA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 7 LEU A 184
TYR A 185
ILE A 242
GLY A 128
 None
 0.90A 4l39B-1jsdA:
undetectable		 4l39B-1jsdA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
HAEMAGGLUTININ (HA2
CHAIN)
(Influenza
A
virus) 		5 / 10 VAL B 115
TYR A   7
GLY B 136
GLY B  23
ASP B 112
 None
 1.26A 4mmcA-1jsdB:
1.5		 4mmcA-1jsdB:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		5 / 12 LEU A 233
VAL A 235
PRO A 244
HIS A 248
GLY A  63
 None
 1.20A 4q15A-1jsdA:
undetectable		 4q15A-1jsdA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 7 TYR A 185
TYR A 151
ALA A 243
ILE A 172
 None
 1.14A 4uymB-1jsdA:
0.0		 4uymB-1jsdA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		5 / 12 LEU A 233
VAL A 235
PRO A 244
HIS A 248
GLY A  63
 None
 1.20A 4ydqA-1jsdA:
undetectable		 4ydqA-1jsdA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 6 TYR A  78
GLY A 266
SER A 265
LEU A  41
 None
 1.23A 5bphA-1jsdA:
undetectable		 5bphA-1jsdA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 4 TYR A  78
GLY A 266
SER A 265
LEU A  41
 None
 1.22A 5bphC-1jsdA:
undetectable		 5bphC-1jsdA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 6 TYR A  78
GLY A 266
SER A 265
LEU A  41
 None
 1.21A 5bphD-1jsdA:
undetectable		 5bphD-1jsdA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 4 ILE A 166
ILE A 114
ARG A 162
LEU A 250
 None
 1.29A 5dzkh-1jsdA:
0.0
5dzkn-1jsdA:
0.0
5dzkv-1jsdA:
undetectable		 5dzkh-1jsdA:
16.98
5dzkn-1jsdA:
16.98
5dzkv-1jsdA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 4 LEU A 167
TYR A 138
PRO A 244
ILE A 116
 None
 1.32A 5esgA-1jsdA:
0.0		 5esgA-1jsdA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		4 / 4 LEU A  60
ARG A 102
ILE A  61
PHE A 105
 None
 1.12A 5kirB-1jsdA:
undetectable		 5kirB-1jsdA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
HAEMAGGLUTININ (HA2
CHAIN)
(Influenza
A
virus) 		5 / 12 ARG A 312
GLY B   8
VAL A  24
GLY B  13
GLY B  12
 None
 0.91A 5koxA-1jsdA:
undetectable		 5koxA-1jsdA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		5 / 12 LEU A 233
VAL A 235
PRO A 244
HIS A 248
GLY A  63
 None
 1.23A 5xipA-1jsdA:
undetectable		 5xipA-1jsdA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		5 / 12 LEU A 233
VAL A 235
PRO A 244
HIS A 248
GLY A  63
 None
 1.22A 5xipC-1jsdA:
undetectable		 5xipC-1jsdA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		5 / 12 LEU A 233
VAL A 235
PRO A 244
HIS A 248
GLY A  63
 None
 1.28A 5xiqA-1jsdA:
undetectable		 5xiqA-1jsdA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		5 / 12 LEU A 233
VAL A 235
PRO A 244
HIS A 248
GLY A  63
 None
 1.23A 5xiqD-1jsdA:
undetectable		 5xiqD-1jsdA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1jsd HAEMAGGLUTININ (HA2
CHAIN)
(Influenza
A
virus) 		4 / 7 VAL B 100
ALA B  96
THR B  93
TYR B  94
 None
 0.94A 6cduH-1jsdB:
2.2
6cduI-1jsdB:
2.2		 6cduH-1jsdB:
18.18
6cduI-1jsdB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 1jsd HAEMAGGLUTININ (HA1
CHAIN)
(Influenza
A
virus) 		5 / 12 LEU A 233
VAL A 235
PRO A 244
HIS A 248
GLY A  63
 None
 1.24A 6mn8A-1jsdA:
undetectable		 6mn8A-1jsdA:
21.60