SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jsw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 8 ALA A  61
GLU A  64
LEU A 248
LEU A 230
 None
 0.94A 1ereE-1jswA:
undetectable		 1ereE-1jswA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 8 ALA A  61
GLU A  64
LEU A 248
LEU A 230
 None
 0.94A 1ereF-1jswA:
0.4		 1ereF-1jswA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 6 GLY A 238
THR A 241
PRO A 242
SER A 246
 None
 0.84A 1n4fA-1jswA:
undetectable		 1n4fA-1jswA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 7 PHE A 457
LEU A 448
VAL A 442
ILE A 411
 None
 0.93A 1t87B-1jswA:
undetectable		 1t87B-1jswA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		5 / 8 GLY A 103
GLY A 101
GLY A 100
SER A 105
HIS A  26
 None
 0.92A 1yajC-1jswA:
undetectable		 1yajC-1jswA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 7 HIS A  26
ASP A 146
THR A 144
TYR A 148
 None
 1.25A 2eijA-1jswA:
0.0
2eijC-1jswA:
4.6		 2eijA-1jswA:
20.18
2eijC-1jswA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 7 HIS A  26
ASP A 146
THR A 144
TYR A 148
 None
 1.23A 2eijN-1jswA:
undetectable
2eijP-1jswA:
4.6		 2eijN-1jswA:
20.18
2eijP-1jswA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 8 ASN A 109
TYR A 148
PHE A  34
ASN A  33
 None
 0.97A 2wekA-1jswA:
undetectable		 2wekA-1jswA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 8 ASN A 109
TYR A 148
PHE A  34
ASN A  33
 None
 0.96A 2wekB-1jswA:
undetectable		 2wekB-1jswA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 7 HIS A  26
ASP A 146
THR A 144
TYR A 148
 None
 1.23A 2y69A-1jswA:
0.0
2y69C-1jswA:
4.6		 2y69A-1jswA:
20.18
2y69C-1jswA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 7 HIS A  26
ASP A 146
THR A 144
TYR A 148
 None
 1.22A 3ag2A-1jswA:
undetectable
3ag2C-1jswA:
4.6		 3ag2A-1jswA:
20.18
3ag2C-1jswA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 7 PHE A 152
LEU A 160
VAL A 376
VAL A 350
 None
 0.97A 3fwfA-1jswA:
undetectable		 3fwfA-1jswA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 7 PHE A 152
LEU A 160
VAL A 376
VAL A 350
 None
 0.98A 3fwfB-1jswA:
undetectable		 3fwfB-1jswA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 7 PHE A 152
LEU A 160
VAL A 376
VAL A 350
 None
 0.98A 3fwjA-1jswA:
undetectable		 3fwjA-1jswA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 7 PHE A 152
LEU A 160
VAL A 376
VAL A 350
 None
 0.96A 3l63A-1jswA:
undetectable		 3l63A-1jswA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 8 LYS A 293
ASP A 297
LEU A 192
LEU A 300
 None
 0.99A 3lm8A-1jswA:
undetectable
3lm8C-1jswA:
undetectable		 3lm8A-1jswA:
18.34
3lm8C-1jswA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 8 LEU A 386
LEU A 210
ILE A 391
PHE A 174
 None
 0.91A 3ln1A-1jswA:
undetectable		 3ln1A-1jswA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 7 LEU A 386
LEU A 210
ILE A 391
PHE A 174
 None
 0.90A 3ln1B-1jswA:
undetectable		 3ln1B-1jswA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		5 / 12 GLY A 275
ALA A 371
GLY A 369
GLU A 374
ASN A 346
 None
 1.29A 3v3oB-1jswA:
0.0		 3v3oB-1jswA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 7 PHE A 152
LEU A 160
VAL A 376
VAL A 350
 None
 0.95A 3wrhA-1jswA:
undetectable		 3wrhA-1jswA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 6 PHE A 152
LEU A 160
VAL A 376
VAL A 350
 None
 0.96A 3wrhE-1jswA:
0.0		 3wrhE-1jswA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 7 PHE A 152
LEU A 160
VAL A 376
VAL A 350
 None
 0.96A 3wrlA-1jswA:
undetectable		 3wrlA-1jswA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 7 PHE A 152
LEU A 160
VAL A 376
VAL A 350
 None
 1.00A 3wrmA-1jswA:
undetectable		 3wrmA-1jswA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 6 PHE A 152
LEU A 160
VAL A 376
VAL A 350
 None
 0.99A 4ek1A-1jswA:
undetectable		 4ek1A-1jswA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		6 / 12 GLY A 103
GLY A 101
GLY A 100
SER A 105
PHE A  34
HIS A  26
 None
 1.36A 4ey6B-1jswA:
undetectable		 4ey6B-1jswA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 5 HIS A  26
TYR A 148
GLN A  99
GLY A 103
 None
 1.20A 4fu8A-1jswA:
undetectable		 4fu8A-1jswA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 6 PHE A 152
LEU A 160
VAL A 376
VAL A 350
 None
 0.93A 4l4cA-1jswA:
undetectable		 4l4cA-1jswA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 5 TYR A 277
LEU A 361
ASP A 146
GLU A 269
 None
 1.27A 4nkvA-1jswA:
0.0		 4nkvA-1jswA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		5 / 12 ALA A 396
LEU A 301
GLY A 201
ASP A 183
ALA A 178
 None
 1.23A 4pclA-1jswA:
undetectable		 4pclA-1jswA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		5 / 11 GLY A 201
ILE A 184
GLY A 393
ILE A 312
PHE A 207
 None
 1.16A 4qoiA-1jswA:
undetectable
4qoiB-1jswA:
undetectable		 4qoiA-1jswA:
18.69
4qoiB-1jswA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		3 / 3 VAL A 156
LEU A 160
VAL A 376
 None
 0.55A 4wq4A-1jswA:
undetectable		 4wq4A-1jswA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		5 / 11 LEU A 225
LEU A 163
LEU A 160
ILE A 218
LEU A 379
 None
 1.04A 4zowA-1jswA:
2.4		 4zowA-1jswA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		3 / 3 ALA A 283
GLN A 219
THR A 221
 None
 0.71A 5n0oA-1jswA:
undetectable		 5n0oA-1jswA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		6 / 12 THR A 271
ALA A 270
ILE A 235
THR A 144
ASN A 229
LEU A 267
 None
 1.49A 5nfjA-1jswA:
undetectable		 5nfjA-1jswA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		5 / 9 VAL A 350
LEU A 379
ALA A 288
VAL A 289
SER A 292
 None
 1.28A 6c2mB-1jswA:
undetectable		 6c2mB-1jswA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		5 / 10 LEU A 163
VAL A 156
VAL A 280
ALA A 222
LEU A 284
 None
 1.07A 6czmA-1jswA:
undetectable
6czmC-1jswA:
undetectable		 6czmA-1jswA:
22.41
6czmC-1jswA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		3 / 3 LEU A 211
ASN A 337
LEU A 379
 None
 0.55A 6exiA-1jswA:
undetectable		 6exiA-1jswA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		3 / 3 THR A 221
ALA A 283
LYS A 285
 None
 0.68A 6fgcA-1jswA:
0.0		 6fgcA-1jswA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 6 GLU A 112
PHE A  93
VAL A  95
PRO A  94
 None
 1.41A 6fgdA-1jswA:
undetectable		 6fgdA-1jswA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		3 / 3 THR A 221
ALA A 283
LYS A 285
 None
 0.72A 6fgdA-1jswA:
0.0		 6fgdA-1jswA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 8 ALA A 147
GLY A 231
LEU A 230
ALA A  58
 None
 0.77A 6mdqA-1jswA:
undetectable		 6mdqA-1jswA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 6 HIS A  26
ASP A 146
THR A 144
TYR A 148
 None
 1.24A 6nknA-1jswA:
0.0
6nknC-1jswA:
4.2		 6nknA-1jswA:
20.18
6nknC-1jswA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1jsw L-ASPARTATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 7 HIS A  26
ASP A 146
THR A 144
TYR A 148
 None
 1.27A 6nmpN-1jswA:
2.4
6nmpP-1jswA:
4.6		 6nmpN-1jswA:
20.18
6nmpP-1jswA:
19.38