SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jsx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B
(Escherichia
coli) 		4 / 8 GLY A  77
GLY A  80
TYR A  27
HIS A  19
 None
 0.89A 1dbbH-1jsxA:
undetectable
1dbbL-1jsxA:
undetectable		 1dbbH-1jsxA:
20.94
1dbbL-1jsxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B
(Escherichia
coli) 		5 / 12 ALA A  90
GLU A  89
ILE A  58
LEU A  16
ILE A  85
 None
 1.03A 1draB-1jsxA:
2.5		 1draB-1jsxA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B
(Escherichia
coli) 		4 / 6 LEU A  78
LEU A  83
LEU A  24
LEU A 199
 None
 0.84A 1errA-1jsxA:
0.8		 1errA-1jsxA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B
(Escherichia
coli) 		5 / 9 ALA A  90
GLU A  89
ILE A  58
LEU A  16
ILE A  85
 None
 1.07A 3jw3B-1jsxA:
4.0		 3jw3B-1jsxA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B
(Escherichia
coli) 		5 / 12 GLY A  73
GLY A  75
LEU A  95
LEU A  98
ALA A 140
 None
 0.43A 3kkzA-1jsxA:
13.7		 3kkzA-1jsxA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B
(Escherichia
coli) 		5 / 12 LEU A 112
LEU A  24
GLY A  77
LEU A  78
PHE A 104
 None
 1.33A 3tbgA-1jsxA:
0.0		 3tbgA-1jsxA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B
(Escherichia
coli) 		4 / 5 ARG A 197
LEU A 188
VAL A 190
ASP A  56
 None
 1.18A 3ufnA-1jsxA:
0.0
3ufnB-1jsxA:
0.0		 3ufnA-1jsxA:
17.62
3ufnB-1jsxA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B
(Escherichia
coli) 		3 / 3 ARG A  68
PHE A 133
PRO A 155
 None
 0.89A 3zoaB-1jsxA:
undetectable		 3zoaB-1jsxA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B
(Escherichia
coli) 		5 / 12 PRO A 131
GLU A 130
ARG A  68
VAL A 120
GLU A 125
 None
 1.33A 4a99A-1jsxA:
2.8
4a99C-1jsxA:
2.7		 4a99A-1jsxA:
21.37
4a99C-1jsxA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B
(Escherichia
coli) 		5 / 12 GLY A  99
GLY A  75
ILE A  81
SER A  84
PRO A 119
 None
 1.18A 4rtsA-1jsxA:
9.5		 4rtsA-1jsxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B
(Escherichia
coli) 		4 / 4 ALA A 140
PRO A  76
LEU A  50
HIS A  53
 None
 1.47A 5eskA-1jsxA:
0.0		 5eskA-1jsxA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B
(Escherichia
coli) 		5 / 12 LEU A 199
ILE A 173
ASP A 171
ARG A 197
ALA A 163
 None
 1.05A 5h5fA-1jsxA:
1.6		 5h5fA-1jsxA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B
(Escherichia
coli) 		3 / 3 HIS A  19
ASN A  22
ALA A  26
 None
 0.17A 5n4tB-1jsxA:
undetectable		 5n4tB-1jsxA:
21.14