SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1juv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  37
PHE A  40
SER A  58
ARG A  66
 None
None
None
NDP  A 194 ( 3.9A)
None
 0.93A 1ao8A-1juvA:
16.6		 1ao8A-1juvA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  37
PHE A  40
THR A  55
SER A  58
 None
None
None
NDP  A 194 (-3.3A)
NDP  A 194 ( 3.9A)
 0.72A 1ao8A-1juvA:
16.6		 1ao8A-1juvA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  28
ASP A  36
LEU A  37
PHE A  40
THR A  55
 None
None
None
None
NDP  A 194 (-3.3A)
 0.92A 1bzfA-1juvA:
17.1		 1bzfA-1juvA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  28
PHE A  40
LYS A  41
THR A  55
LEU A  63
ILE A 127
 None
None
None
NDP  A 194 (-3.3A)
None
None
 1.22A 1cd2A-1juvA:
14.8		 1cd2A-1juvA:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  28
PHE A  40
THR A  55
PRO A  60
LEU A  63
ILE A 127
 None
None
NDP  A 194 (-3.3A)
None
None
None
 1.06A 1cd2A-1juvA:
14.8		 1cd2A-1juvA:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 VAL A   5
ASP A  36
LEU A  63
ARG A  66
ILE A 127
 None
 0.85A 1d1gB-1juvA:
14.2		 1d1gB-1juvA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  37
THR A  55
LEU A  63
ARG A  66
 None
None
NDP  A 194 (-3.3A)
None
None
 0.99A 1ddrA-1juvA:
16.7		 1ddrA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
PHE A  40
LYS A  41
LEU A  63
ARG A  66
 None
 0.89A 1ddrB-1juvA:
17.0		 1ddrB-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
LYS A  41
THR A  55
LEU A  63
ARG A  66
 None
None
None
NDP  A 194 (-3.3A)
None
None
 1.29A 1ddsA-1juvA:
17.0		 1ddsA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
LYS A  41
SER A  58
LEU A  63
ARG A  66
 None
None
None
NDP  A 194 ( 3.9A)
None
None
 1.21A 1ddsB-1juvA:
17.3		 1ddsB-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  59
PRO A  60
LEU A  63
ARG A  66
 None
 0.76A 1df7A-1juvA:
16.8		 1df7A-1juvA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  59
PRO A  60
LEU A  63
ILE A 127
 None
 0.78A 1df7A-1juvA:
16.8		 1df7A-1juvA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 11 ASP A  36
PHE A  40
LEU A  59
PRO A  60
ILE A 127
 None
 0.52A 1dg5A-1juvA:
16.6		 1dg5A-1juvA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 11 ASP A  36
SER A  58
LEU A  59
PRO A  60
ILE A 127
 None
NDP  A 194 ( 3.9A)
None
None
None
 0.77A 1dg5A-1juvA:
16.6		 1dg5A-1juvA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 ASP A  36
LEU A  37
PHE A  40
LYS A  41
SER A  58
LEU A  63
ARG A  66
 None
None
None
None
NDP  A 194 ( 3.9A)
None
None
 1.15A 1dreA-1juvA:
17.7		 1dreA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
PHE A  40
LYS A  41
THR A  55
LEU A  63
 None
None
None
None
NDP  A 194 (-3.3A)
None
 1.18A 1dyiA-1juvA:
17.1		 1dyiA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
PHE A  40
LYS A  41
THR A  55
LEU A  63
 None
None
None
None
NDP  A 194 (-3.3A)
None
 1.12A 1dyiB-1juvA:
17.3		 1dyiB-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  37
PHE A  40
LYS A  41
LEU A  63
 None
 0.91A 1jolA-1juvA:
17.1		 1jolA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
PHE A  40
LYS A  41
LEU A  63
PRO A  64
 None
 0.94A 1jolB-1juvA:
17.3		 1jolB-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 11 ASP A  36
LEU A  37
PHE A  40
LYS A  41
LEU A  63
ARG A  66
 None
 1.05A 1jomA-1juvA:
16.7		 1jomA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
THR A  55
LEU A  63
ARG A  66
 None
None
None
None
NDP  A 194 (-3.3A)
None
None
 0.91A 1qzfA-1juvA:
9.3		 1qzfA-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
THR A  55
LEU A  63
ARG A  66
 None
None
None
None
NDP  A 194 (-3.3A)
None
None
 0.92A 1qzfB-1juvA:
15.6		 1qzfB-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
THR A  55
LEU A  63
ARG A  66
 None
None
None
None
NDP  A 194 (-3.3A)
None
None
 0.92A 1qzfC-1juvA:
9.8		 1qzfC-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
THR A  55
LEU A  63
ARG A  66
 None
None
None
None
NDP  A 194 (-3.3A)
None
None
 0.92A 1qzfD-1juvA:
9.2		 1qzfD-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
THR A  55
LEU A  63
ARG A  66
 None
None
None
None
NDP  A 194 (-3.3A)
None
None
 0.91A 1qzfE-1juvA:
9.3		 1qzfE-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  37
PHE A  40
LEU A  63
ILE A 127
 None
 0.97A 1ra2A-1juvA:
17.0		 1ra2A-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  37
PHE A  40
THR A  55
LEU A  63
ILE A 127
 None
None
NDP  A 194 (-3.3A)
None
None
 0.94A 1ra8A-1juvA:
17.0		 1ra8A-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
PHE A  40
LYS A  41
LEU A  63
ILE A 127
 None
 1.07A 1rb2A-1juvA:
17.1		 1rb2A-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
PHE A  40
LEU A  63
ARG A  66
ILE A 127
 None
 0.97A 1rb2B-1juvA:
17.1		 1rb2B-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 ASP A  36
LEU A  37
LYS A  41
SER A  58
LEU A  63
ARG A  66
ILE A 127
 None
None
None
NDP  A 194 ( 3.9A)
None
None
None
 0.88A 1rb3B-1juvA:
17.4		 1rb3B-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  37
PHE A  40
LYS A  41
THR A  55
LEU A  63
ILE A 127
 None
None
None
NDP  A 194 (-3.3A)
None
None
 1.03A 1rd7A-1juvA:
16.7		 1rd7A-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
LYS A  41
THR A  55
LEU A  63
ILE A 127
 None
None
None
NDP  A 194 (-3.3A)
None
None
 1.19A 1rd7B-1juvA:
16.7		 1rd7B-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
PHE A  40
LYS A  41
THR A  55
ILE A 127
 None
None
None
None
NDP  A 194 (-3.3A)
None
 0.80A 1re7A-1juvA:
16.7		 1re7A-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
PHE A  40
LEU A  63
PRO A  64
ILE A 127
 None
 0.82A 1re7B-1juvA:
16.7		 1re7B-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
PHE A  40
LYS A  41
LEU A  63
PRO A  64
ILE A 127
 None
 1.29A 1re7B-1juvA:
16.7		 1re7B-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 ASP A  36
LEU A  37
PHE A  40
LYS A  41
SER A  58
LEU A  63
ARG A  66
 None
None
None
None
NDP  A 194 ( 3.9A)
None
None
 1.19A 1rh3A-1juvA:
17.8		 1rh3A-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  37
PHE A  40
LYS A  41
LEU A  63
ILE A 127
 None
 0.88A 1rx2A-1juvA:
18.0		 1rx2A-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
PHE A  40
SER A  58
LEU A  63
ARG A  66
 None
None
None
NDP  A 194 ( 3.9A)
None
None
 0.99A 1rx3A-1juvA:
18.0		 1rx3A-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
PHE A  40
THR A  55
LEU A  63
ILE A 127
 None
None
None
NDP  A 194 (-3.3A)
None
None
 0.84A 1rx7A-1juvA:
16.6		 1rx7A-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
PHE A  40
LYS A  41
THR A  55
LEU A  63
ILE A 127
 None
None
None
NDP  A 194 (-3.3A)
None
None
 1.15A 1rx7A-1juvA:
16.6		 1rx7A-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 ASP A  36
LEU A  37
PHE A  40
LYS A  41
THR A  55
LEU A  63
ARG A  66
 None
None
None
None
NDP  A 194 (-3.3A)
None
None
 1.22A 1tdrA-1juvA:
17.1		 1tdrA-1juvA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 10 ASP A  36
LEU A  37
LYS A  41
LEU A  63
ARG A  66
 None
 1.12A 1tdrB-1juvA:
17.1		 1tdrB-1juvA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  28
SER A  58
PRO A  60
LEU A  63
ARG A  66
 None
NDP  A 194 ( 3.9A)
None
None
None
 0.87A 1u72A-1juvA:
16.8		 1u72A-1juvA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 7 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 0.97A 1v55C-1juvA:
undetectable
1v55J-1juvA:
0.0		 1v55C-1juvA:
18.99
1v55J-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 7 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 0.98A 1v55P-1juvA:
undetectable
1v55W-1juvA:
undetectable		 1v55P-1juvA:
18.99
1v55W-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  28
ASP A  36
PHE A  40
SER A  58
ILE A 127
 None
None
None
NDP  A 194 ( 3.9A)
None
 0.79A 2bl9A-1juvA:
16.5		 2bl9A-1juvA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  37
PHE A  40
THR A  55
LEU A  63
ARG A  66
 None
None
NDP  A 194 (-3.3A)
None
None
 0.95A 2d0kB-1juvA:
16.3		 2d0kB-1juvA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  37
PHE A  40
THR A  55
LEU A  63
ILE A 127
 None
None
NDP  A 194 (-3.3A)
None
None
 0.94A 2d0kB-1juvA:
16.3		 2d0kB-1juvA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  37
LYS A  41
LEU A  63
ARG A  66
 None
 1.04A 2drcB-1juvA:
17.3		 2drcB-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 7 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 1.05A 2dysP-1juvA:
undetectable
2dysW-1juvA:
0.0		 2dysP-1juvA:
18.99
2dysW-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 7 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 0.97A 2eijC-1juvA:
undetectable
2eijJ-1juvA:
undetectable		 2eijC-1juvA:
18.99
2eijJ-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 7 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 0.97A 2eijP-1juvA:
undetectable
2eijW-1juvA:
undetectable		 2eijP-1juvA:
18.99
2eijW-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 8 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 0.98A 2eilP-1juvA:
undetectable
2eilW-1juvA:
undetectable		 2eilP-1juvA:
18.99
2eilW-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 7 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 1.00A 2eimC-1juvA:
undetectable
2eimJ-1juvA:
0.0		 2eimC-1juvA:
18.99
2eimJ-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 7 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 1.04A 2einC-1juvA:
undetectable
2einJ-1juvA:
0.0		 2einC-1juvA:
18.99
2einJ-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 6 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 0.97A 2einP-1juvA:
undetectable
2einW-1juvA:
0.0		 2einP-1juvA:
18.99
2einW-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		8 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
PHE A  40
THR A  55
LEU A  63
ARG A  66
 None
None
None
None
None
NDP  A 194 (-3.3A)
None
None
 0.88A 2oipA-1juvA:
15.9		 2oipA-1juvA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 LEU A  28
ASP A  36
LEU A  37
PHE A  40
THR A  55
LEU A  63
ARG A  66
 None
None
None
None
NDP  A 194 (-3.3A)
None
None
 0.82A 2oipB-1juvA:
14.5		 2oipB-1juvA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		8 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
PHE A  40
THR A  55
LEU A  63
ARG A  66
 None
None
None
None
None
NDP  A 194 (-3.3A)
None
None
 0.80A 2oipC-1juvA:
15.9		 2oipC-1juvA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 LEU A  28
ASP A  36
LEU A  37
PHE A  40
THR A  55
LEU A  63
ARG A  66
 None
None
None
None
NDP  A 194 (-3.3A)
None
None
 0.86A 2oipD-1juvA:
16.5		 2oipD-1juvA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
PHE A  40
THR A  55
LEU A  63
ARG A  66
 None
None
None
NDP  A 194 (-3.3A)
None
None
 0.82A 2oipE-1juvA:
15.6		 2oipE-1juvA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  28
LEU A  37
PHE A  40
THR A  55
LEU A  63
ARG A  66
 None
None
None
NDP  A 194 (-3.3A)
None
None
 0.77A 2oipE-1juvA:
15.6		 2oipE-1juvA:
16.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  37
LYS A  41
LEU A  63
PRO A  64
ARG A  66
 None
 1.16A 2qk8A-1juvA:
17.6		 2qk8A-1juvA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 VAL A   5
ASP A  36
LEU A  37
PHE A  40
LEU A  59
ILE A 127
 None
 0.85A 2w3vA-1juvA:
16.8		 2w3vA-1juvA:
30.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 VAL A   5
ASP A  36
LEU A  37
SER A  58
LEU A  59
 None
None
None
NDP  A 194 ( 3.9A)
None
 0.87A 2w3vA-1juvA:
16.8		 2w3vA-1juvA:
30.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 SER A 146
ILE A 127
MET A  49
LEU A 187
TYR A 179
 None
 1.01A 2xkwA-1juvA:
0.0		 2xkwA-1juvA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 7 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 1.00A 2zxwC-1juvA:
undetectable
2zxwJ-1juvA:
undetectable		 2zxwC-1juvA:
18.99
2zxwJ-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 6 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 0.99A 2zxwP-1juvA:
undetectable
2zxwW-1juvA:
0.0		 2zxwP-1juvA:
18.99
2zxwW-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 7 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 0.99A 3ag2C-1juvA:
undetectable		 3ag2C-1juvA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 7 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 0.97A 3ag2P-1juvA:
undetectable
3ag2W-1juvA:
undetectable		 3ag2P-1juvA:
18.99
3ag2W-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 8 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 0.98A 3asoC-1juvA:
undetectable
3asoJ-1juvA:
undetectable		 3asoC-1juvA:
18.99
3asoJ-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
THR A  55
PRO A  60
LEU A  63
PRO A  64
ARG A  66
 None
NDP  A 194 (-3.3A)
None
None
None
None
 0.88A 3cl9A-1juvA:
13.0		 3cl9A-1juvA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
PHE A  40
THR A  55
SER A  58
ILE A 127
 None
None
NDP  A 194 (-3.3A)
NDP  A 194 ( 3.9A)
None
 0.52A 3clbB-1juvA:
8.3		 3clbB-1juvA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 VAL A   5
ASP A  36
THR A  55
LEU A  63
ILE A 127
 None
None
NDP  A 194 (-3.3A)
None
None
 0.94A 3clbC-1juvA:
14.9		 3clbC-1juvA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 VAL A   5
ASP A  36
THR A  55
PRO A  60
ILE A 127
 None
None
NDP  A 194 (-3.3A)
None
None
 0.96A 3clbC-1juvA:
14.9		 3clbC-1juvA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  37
LYS A  41
LEU A  63
ARG A  66
 None
 1.05A 3dauA-1juvA:
18.2		 3dauA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  28
ASP A  36
LEU A  37
PRO A  60
LEU A  63
ARG A  66
 None
 0.93A 3dfrA-1juvA:
17.9		 3dfrA-1juvA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  28
ASP A  36
LEU A  37
SER A  58
PRO A  60
LEU A  63
 None
None
None
NDP  A 194 ( 3.9A)
None
None
 0.81A 3dfrA-1juvA:
17.9		 3dfrA-1juvA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  37
LYS A  41
LEU A  63
ARG A  66
 None
 1.01A 3drcB-1juvA:
17.4		 3drcB-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  37
LYS A  41
LEU A  63
ILE A 127
 None
 1.07A 3drcB-1juvA:
17.4		 3drcB-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 9 VAL A   5
ASP A  36
THR A  55
SER A  58
ILE A 127
 None
None
NDP  A 194 (-3.3A)
NDP  A 194 ( 3.9A)
None
 0.70A 3hbbB-1juvA:
14.5		 3hbbB-1juvA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 LEU A  28
ASP A  36
LEU A  37
PHE A  40
THR A  55
LEU A  63
ARG A  66
 None
None
None
None
NDP  A 194 (-3.3A)
None
None
 0.89A 3hj3A-1juvA:
16.5		 3hj3A-1juvA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 LEU A  28
ASP A  36
LEU A  37
PHE A  40
THR A  55
LEU A  63
ARG A  66
 None
None
None
None
NDP  A 194 (-3.3A)
None
None
 0.89A 3hj3B-1juvA:
16.5		 3hj3B-1juvA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		8 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
PHE A  40
THR A  55
LEU A  63
ARG A  66
 None
None
None
None
None
NDP  A 194 (-3.3A)
None
None
 0.84A 3hj3C-1juvA:
15.3		 3hj3C-1juvA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 VAL A   5
ASP A  36
LEU A  37
PHE A  40
THR A  55
LEU A  63
ARG A  66
 None
None
None
None
NDP  A 194 (-3.3A)
None
None
 0.99A 3hj3D-1juvA:
6.5		 3hj3D-1juvA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 VAL A   5
LEU A  28
LEU A  37
PHE A  40
THR A  55
LEU A  63
ARG A  66
 None
None
None
None
NDP  A 194 (-3.3A)
None
None
 0.83A 3hj3D-1juvA:
6.5		 3hj3D-1juvA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  37
LYS A  41
SER A  58
LEU A  63
ARG A  66
 None
None
NDP  A 194 ( 3.9A)
None
None
 1.23A 3ia4A-1juvA:
18.3		 3ia4A-1juvA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  37
PHE A  40
LYS A  41
SER A  58
LEU A  63
ARG A  66
 None
None
None
NDP  A 194 ( 3.9A)
None
None
 1.09A 3ia4C-1juvA:
18.3		 3ia4C-1juvA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  37
PHE A  40
LYS A  41
LEU A  63
ARG A  66
 None
 1.02A 3ia4D-1juvA:
18.5		 3ia4D-1juvA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  28
LEU A  37
GLN A  38
LYS A  41
LEU A  63
ARG A  66
 None
 0.97A 3ix9A-1juvA:
18.5		 3ix9A-1juvA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  28
LEU A  37
LYS A  41
LEU A  63
ARG A  66
 None
 1.01A 3ix9B-1juvA:
19.1		 3ix9B-1juvA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 VAL A   5
ASP A  36
PHE A  40
THR A  55
SER A  58
LEU A  59
ILE A 127
 None
None
None
NDP  A 194 (-3.3A)
NDP  A 194 ( 3.9A)
None
None
 0.62A 3qfxA-1juvA:
14.7		 3qfxA-1juvA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 VAL A   5
ASP A  36
PHE A  40
THR A  55
SER A  58
LEU A  59
ILE A 127
 None
None
None
NDP  A 194 (-3.3A)
NDP  A 194 ( 3.9A)
None
None
 0.60A 3qfxB-1juvA:
14.6		 3qfxB-1juvA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  37
PHE A  40
LYS A  41
LEU A  63
ARG A  66
 None
 1.07A 3ql0A-1juvA:
18.4		 3ql0A-1juvA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 LEU A  28
ASP A  36
LEU A  37
LYS A  41
SER A  58
LEU A  63
ARG A  66
 None
None
None
None
NDP  A 194 ( 3.9A)
None
None
 1.20A 3tq9A-1juvA:
17.9		 3tq9A-1juvA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 LEU A  28
ASP A  36
LEU A  37
LYS A  41
SER A  58
LEU A  63
ILE A 127
 None
None
None
None
NDP  A 194 ( 3.9A)
None
None
 1.11A 3tq9A-1juvA:
17.9		 3tq9A-1juvA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		8 / 11 LEU A  28
ASP A  36
LEU A  37
LYS A  41
THR A  55
LEU A  63
ARG A  66
ILE A 127
 None
None
None
None
NDP  A 194 (-3.3A)
None
None
None
 1.19A 3tqbA-1juvA:
17.9		 3tqbA-1juvA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 10 ASP A  36
PHE A  40
THR A  55
SER A  58
ILE A 127
 None
None
NDP  A 194 (-3.3A)
NDP  A 194 ( 3.9A)
None
 0.63A 3um5A-1juvA:
15.9		 3um5A-1juvA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 10 ASP A  36
PHE A  40
THR A  55
SER A  58
ILE A 127
 None
None
NDP  A 194 (-3.3A)
NDP  A 194 ( 3.9A)
None
 0.66A 3um5B-1juvA:
15.7		 3um5B-1juvA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 7 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 0.97A 3x2qP-1juvA:
undetectable
3x2qW-1juvA:
undetectable		 3x2qP-1juvA:
18.99
3x2qW-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
LYS A  41
THR A  55
LEU A  63
ARG A  66
 None
None
None
NDP  A 194 (-3.3A)
None
None
 1.27A 4dfrA-1juvA:
17.1		 4dfrA-1juvA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  37
LYS A  41
LEU A  63
ARG A  66
 None
 1.05A 4dfrB-1juvA:
17.4		 4dfrB-1juvA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 VAL A   5
LEU A  28
PHE A  40
LEU A  63
ARG A  66
 None
 1.04A 4eckA-1juvA:
14.8		 4eckA-1juvA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 VAL A   5
LEU A  28
PHE A  40
LEU A  63
ARG A  66
 None
 1.14A 4eckB-1juvA:
15.1		 4eckB-1juvA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  37
PHE A  40
LYS A  41
THR A  55
LEU A  63
ILE A 127
 None
None
None
NDP  A 194 (-3.3A)
None
None
 1.11A 4ej1A-1juvA:
16.6		 4ej1A-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ILE A 127
LEU A  37
PHE A  40
LYS A  41
LEU A  63
ARG A  66
 None
 1.49A 4fhbA-1juvA:
17.2		 4fhbA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 LEU A  37
PHE A  40
LYS A  41
THR A  55
LEU A  63
ARG A  66
ILE A 127
 None
None
None
NDP  A 194 (-3.3A)
None
None
None
 1.12A 4fhbA-1juvA:
17.2		 4fhbA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  37
SER A  58
LEU A  63
ARG A  66
 None
None
NDP  A 194 ( 3.9A)
None
None
 0.72A 4gh8A-1juvA:
18.1		 4gh8A-1juvA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  37
SER A  58
PRO A  60
ARG A  66
 None
None
NDP  A 194 ( 3.9A)
None
None
 0.82A 4gh8A-1juvA:
18.1		 4gh8A-1juvA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
LYS A  41
SER A  58
PRO A  60
ARG A  66
 None
None
None
NDP  A 194 ( 3.9A)
None
None
 1.07A 4gh8B-1juvA:
18.4		 4gh8B-1juvA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  37
PHE A  40
LYS A  41
THR A  55
LEU A  63
ILE A 127
 None
None
None
NDP  A 194 (-3.3A)
None
None
 1.11A 4i13A-1juvA:
16.8		 4i13A-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 11 ASP A  36
LEU A  37
PHE A  40
LYS A  41
LEU A  63
ARG A  66
 None
 0.99A 4i1nA-1juvA:
16.7		 4i1nA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 7 PHE A  40
GLU A 189
SER A 146
VAL A 144
 None
 1.20A 4k5jA-1juvA:
undetectable
4k5jB-1juvA:
undetectable		 4k5jA-1juvA:
17.42
4k5jB-1juvA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 PHE A  40
LYS A  41
THR A  55
LEU A  63
ILE A 127
 None
None
NDP  A 194 (-3.3A)
None
None
 1.08A 4kjkA-1juvA:
18.1		 4kjkA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 10 ASP A  36
PHE A  40
THR A  55
LEU A  59
ILE A 127
 None
None
NDP  A 194 (-3.3A)
None
None
 0.78A 4km0A-1juvA:
15.8		 4km0A-1juvA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
PHE A  40
THR A  55
LEU A  59
ILE A 127
 None
None
NDP  A 194 (-3.3A)
None
None
 0.75A 4km0B-1juvA:
16.2		 4km0B-1juvA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
LEU A  63
ARG A  66
 None
 0.91A 4ky8A-1juvA:
4.6		 4ky8A-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
SER A  58
ARG A  66
 None
None
None
None
NDP  A 194 ( 3.9A)
None
 0.87A 4ky8A-1juvA:
4.6		 4ky8A-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
LEU A  63
ARG A  66
 None
 0.86A 4ky8B-1juvA:
11.8		 4ky8B-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
SER A  58
ARG A  66
 None
None
None
None
NDP  A 194 ( 3.9A)
None
 0.85A 4ky8B-1juvA:
11.8		 4ky8B-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
LEU A  63
ARG A  66
 None
 0.91A 4ky8C-1juvA:
16.5		 4ky8C-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
LEU A  63
ARG A  66
 None
 0.89A 4ky8D-1juvA:
2.5		 4ky8D-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
SER A  58
ARG A  66
 None
None
None
None
NDP  A 194 ( 3.9A)
None
 0.87A 4ky8D-1juvA:
2.5		 4ky8D-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
LEU A  63
ARG A  66
 None
 0.91A 4ky8E-1juvA:
16.4		 4ky8E-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
SER A  58
ARG A  66
 None
None
None
None
NDP  A 194 ( 3.9A)
None
 0.91A 4ky8E-1juvA:
16.4		 4ky8E-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 11 VAL A   5
ASP A  36
THR A  55
LEU A  63
ARG A  66
 None
None
NDP  A 194 (-3.3A)
None
None
 0.82A 4kyaA-1juvA:
15.7		 4kyaA-1juvA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 11 VAL A   5
ASP A  36
THR A  55
LEU A  63
ARG A  66
 None
None
NDP  A 194 (-3.3A)
None
None
 0.80A 4kyaE-1juvA:
15.5		 4kyaE-1juvA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 11 VAL A   5
ASP A  36
THR A  55
LEU A  63
ARG A  66
 None
None
NDP  A 194 (-3.3A)
None
None
 0.83A 4kyaG-1juvA:
15.6		 4kyaG-1juvA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
PHE A  40
LEU A  59
LEU A  63
ILE A 127
 None
 0.81A 4m2xA-1juvA:
16.7		 4m2xA-1juvA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
PHE A  40
LEU A  59
PRO A  60
ILE A 127
 None
 0.40A 4m2xA-1juvA:
16.7		 4m2xA-1juvA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  59
PRO A  60
LEU A  63
ILE A 127
 None
 0.77A 4m2xC-1juvA:
16.8		 4m2xC-1juvA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  59
PRO A  60
LEU A  63
ILE A 127
 None
 0.84A 4m2xE-1juvA:
16.6		 4m2xE-1juvA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  37
PHE A  40
LYS A  41
THR A  55
LEU A  63
ILE A 127
 None
None
None
NDP  A 194 (-3.3A)
None
None
 0.85A 4nx6A-1juvA:
18.0		 4nx6A-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  37
PHE A  40
LYS A  41
THR A  55
LEU A  63
ILE A 127
 None
None
None
NDP  A 194 (-3.3A)
None
None
 0.83A 4nx7A-1juvA:
18.1		 4nx7A-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 PHE A  40
LYS A  41
THR A  55
LEU A  63
ILE A 127
 None
None
NDP  A 194 (-3.3A)
None
None
 0.78A 4p3qA-1juvA:
17.9		 4p3qA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 PHE A  40
LYS A  41
THR A  55
LEU A  63
PRO A  64
 None
None
NDP  A 194 (-3.3A)
None
None
 0.82A 4p3qA-1juvA:
17.9		 4p3qA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  37
PHE A  40
LYS A  41
THR A  55
LEU A  63
ILE A 127
 None
None
None
NDP  A 194 (-3.3A)
None
None
 1.03A 4p3rA-1juvA:
18.2		 4p3rA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 11 ASP A  36
LEU A  37
LYS A  41
LEU A  63
ARG A  66
 None
 1.12A 4p66A-1juvA:
18.0		 4p66A-1juvA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 11 ASP A  36
LEU A  37
LYS A  41
LEU A  63
ILE A 127
 None
 1.14A 4p66A-1juvA:
18.0		 4p66A-1juvA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 11 ASP A  36
PHE A  40
LYS A  41
SER A  58
ARG A  66
 None
None
None
NDP  A 194 ( 3.9A)
None
 1.34A 4p68A-1juvA:
17.8		 4p68A-1juvA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 11 ASP A  36
PHE A  40
LYS A  41
SER A  58
ILE A 127
 None
None
None
NDP  A 194 ( 3.9A)
None
 0.91A 4p68A-1juvA:
17.8		 4p68A-1juvA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  37
PHE A  40
THR A  55
LEU A  63
ILE A 127
 None
None
NDP  A 194 (-3.3A)
None
None
 0.89A 4pssA-1juvA:
undetectable		 4pssA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  37
PHE A  40
LYS A  41
THR A  55
LEU A  63
ILE A 127
 None
None
None
NDP  A 194 (-3.3A)
None
None
 1.03A 4pstA-1juvA:
undetectable		 4pstA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		3 / 3 ASP A  36
LEU A  37
PHE A  40
 None
 0.45A 4pthA-1juvA:
18.0		 4pthA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
LEU A  63
ARG A  66
 None
 0.88A 4q0dA-1juvA:
16.3		 4q0dA-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
LEU A  63
ARG A  66
 None
 0.88A 4q0dB-1juvA:
16.3		 4q0dB-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  28
ASP A  36
LEU A  37
LEU A  63
ARG A  66
 None
 0.91A 4q0dC-1juvA:
16.3		 4q0dC-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  28
ASP A  36
LEU A  37
LEU A  63
ARG A  66
 None
 0.92A 4q0dD-1juvA:
16.3		 4q0dD-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 VAL A   5
LEU A  28
ASP A  36
LEU A  37
LEU A  63
ARG A  66
 None
 0.88A 4q0dE-1juvA:
16.3		 4q0dE-1juvA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  37
LYS A  41
LEU A  63
ARG A  66
 None
 1.09A 4qi9A-1juvA:
15.5		 4qi9A-1juvA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  37
LYS A  41
LEU A  63
ARG A  66
 None
 1.13A 4qi9B-1juvA:
15.7		 4qi9B-1juvA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
PHE A  40
LYS A  41
THR A  55
LEU A  63
 None
None
None
None
NDP  A 194 (-3.3A)
None
 1.16A 4qleA-1juvA:
17.4		 4qleA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 11 ASP A  36
LEU A  37
LYS A  41
LEU A  63
ARG A  66
 None
 0.98A 4qleB-1juvA:
17.4		 4qleB-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 11 ASP A  36
LEU A  37
PHE A  40
LYS A  41
LEU A  63
ARG A  66
 None
 0.88A 4qlfA-1juvA:
15.1		 4qlfA-1juvA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
PHE A  40
LYS A  41
LEU A  63
ARG A  66
 None
 1.06A 4qlgA-1juvA:
17.3		 4qlgA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		7 / 12 ASP A  36
LEU A  37
PHE A  40
LYS A  41
THR A  55
LEU A  63
ARG A  66
 None
None
None
None
NDP  A 194 (-3.3A)
None
None
 1.12A 4qlgB-1juvA:
17.1		 4qlgB-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
PHE A  40
LYS A  41
LEU A  63
ARG A  66
 None
 1.07A 4rgcA-1juvA:
18.1		 4rgcA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  37
PHE A  40
THR A  55
LEU A  63
ARG A  66
 None
None
NDP  A 194 (-3.3A)
None
None
 0.86A 4x5fA-1juvA:
16.9		 4x5fA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  37
PHE A  40
THR A  55
LEU A  63
ARG A  66
 None
None
NDP  A 194 (-3.3A)
None
None
 0.86A 4x5fB-1juvA:
17.0		 4x5fB-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  37
PHE A  40
THR A  55
LEU A  63
 None
None
None
NDP  A 194 (-3.3A)
None
 0.86A 4x5gA-1juvA:
17.1		 4x5gA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 7 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 0.94A 5b1aP-1juvA:
undetectable
5b1aW-1juvA:
undetectable		 5b1aP-1juvA:
18.99
5b1aW-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 7 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 1.00A 5b1bP-1juvA:
undetectable
5b1bW-1juvA:
0.0		 5b1bP-1juvA:
18.99
5b1bW-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 7 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 0.98A 5b3sP-1juvA:
undetectable		 5b3sP-1juvA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  37
PHE A  40
LYS A  41
THR A  55
ILE A 127
 None
None
None
NDP  A 194 (-3.3A)
None
 0.76A 5e8qA-1juvA:
17.2		 5e8qA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		3 / 3 ASP A  36
LEU A  63
ARG A  66
 None
 0.86A 5e8qA-1juvA:
17.2		 5e8qA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  37
PHE A  40
LYS A  41
THR A  55
LEU A  63
PRO A  64
 None
None
None
NDP  A 194 (-3.3A)
None
None
 1.30A 5eajB-1juvA:
17.3		 5eajB-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 4 THR A  44
LEU A  63
HIS A  68
GLY A  65
 None
 1.33A 5gwyA-1juvA:
undetectable		 5gwyA-1juvA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 ASP A  36
LEU A  37
LYS A  41
LEU A  63
ARG A  66
 None
 1.12A 5hi6A-1juvA:
17.0		 5hi6A-1juvA:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ASP A  36
LEU A  37
LYS A  41
SER A  58
LEU A  63
ARG A  66
 None
None
None
NDP  A 194 ( 3.9A)
None
None
 1.21A 5hi6B-1juvA:
17.1		 5hi6B-1juvA:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 6 THR A 157
GLY A  23
PHE A  22
ILE A 148
 None
NDP  A 194 (-3.3A)
NDP  A 194 (-3.6A)
None
 0.86A 5kmfA-1juvA:
undetectable
5kmfC-1juvA:
undetectable		 5kmfA-1juvA:
22.76
5kmfC-1juvA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 GLY A 128
GLY A  52
ALA A 131
LEU A 133
ALA A 136
 NDP  A 194 (-3.5A)
NDP  A 194 (-2.8A)
None
None
None
 0.89A 5kpcA-1juvA:
undetectable		 5kpcA-1juvA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  37
PHE A  40
LYS A  41
THR A  55
LEU A  63
ILE A 127
 None
None
None
NDP  A 194 (-3.3A)
None
None
 1.22A 5ujxA-1juvA:
17.2		 5ujxA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 ILE A 127
LEU A  37
PHE A  40
LYS A  41
LEU A  63
ARG A  66
 None
 1.46A 5ujxB-1juvA:
17.3		 5ujxB-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  37
PHE A  40
LYS A  41
THR A  55
LEU A  63
ARG A  66
 None
None
None
NDP  A 194 (-3.3A)
None
None
 1.18A 5ujxB-1juvA:
17.3		 5ujxB-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 12 LEU A  37
PHE A  40
LYS A  41
THR A  55
ARG A  66
 None
None
None
NDP  A 194 (-3.3A)
None
 1.03A 5z6fA-1juvA:
17.8		 5z6fA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  37
PHE A  40
LYS A  41
THR A  55
LEU A  63
ILE A 127
 None
None
None
NDP  A 194 (-3.3A)
None
None
 1.13A 5z6jA-1juvA:
18.0		 5z6jA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		6 / 12 LEU A  37
PHE A  40
LYS A  41
THR A  55
LEU A  63
ILE A 127
 None
None
None
NDP  A 194 (-3.3A)
None
None
 1.16A 5z6kA-1juvA:
18.0		 5z6kA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 9 ASP A  36
LEU A  37
LYS A  41
PRO A  64
ARG A  66
 None
 1.21A 5z6lA-1juvA:
17.6		 5z6lA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		5 / 9 ILE A 127
LEU A  37
LYS A  41
PRO A  64
ARG A  66
 None
 1.46A 5z6lA-1juvA:
17.6		 5z6lA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		4 / 7 SER A 146
VAL A 144
PHE A  40
GLU A 189
 None
 1.25A 6av7A-1juvA:
0.0
6av7B-1juvA:
undetectable		 6av7A-1juvA:
13.40
6av7B-1juvA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1juv DIHYDROFOLATE
REDUCTASE
(Escherichia
virus
T4) 		3 / 3 ASP A  36
LEU A  37
ARG A  66
 None
 0.61A 7dfrA-1juvA:
17.9		 7dfrA-1juvA:
27.22