SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jvb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 11 ILE A 331
ASN A 333
LEU A 345
GLY A  36
MET A 322
 None
 1.35A 1hvyC-1jvbA:
0.0		 1hvyC-1jvbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 8 VAL A 202
LEU A 175
PRO A 228
VAL A 256
 None
 1.16A 1jtvA-1jvbA:
undetectable		 1jtvA-1jvbA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 5 GLY A 265
GLN A 290
VAL A 268
SER A 167
 None
 1.12A 1p6kB-1jvbA:
0.0		 1p6kB-1jvbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 5 GLY A 265
GLN A 290
VAL A 268
SER A 167
 None
 1.15A 1rs6B-1jvbA:
0.0		 1rs6B-1jvbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 6 GLY A 265
GLN A 290
VAL A 268
SER A 167
 None
 1.10A 1rs7B-1jvbA:
undetectable		 1rs7B-1jvbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 5 GLY A 265
GLN A 290
VAL A 268
SER A 167
 None
 1.12A 1zzuB-1jvbA:
0.0		 1zzuB-1jvbA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		3 / 3 ARG A 342
VAL A 314
GLY A 304
 None
 0.42A 2avvE-1jvbA:
undetectable		 2avvE-1jvbA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 120
LEU A  13
ASP A  41
ILE A   9
ILE A  54
 None
 0.94A 2bl9A-1jvbA:
3.0		 2bl9A-1jvbA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A   6
ASP A  57
ILE A 120
GLY A  50
LEU A  66
 None
 1.01A 2o4nA-1jvbA:
undetectable		 2o4nA-1jvbA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 247
GLY A 180
GLY A 178
VAL A 220
THR A 185
 None
 1.06A 3dh0B-1jvbA:
6.7		 3dh0B-1jvbA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 8 GLY A 184
ALA A 187
VAL A 163
GLY A 156
ILE A 245
 None
 1.20A 3ekpA-1jvbA:
undetectable		 3ekpA-1jvbA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		3 / 3 GLU A  69
VAL A  37
CYH A  38
 ZN  A 500 ( 3.0A)
None
ZN  A 500 ( 2.3A)
 1.00A 3fbxA-1jvbA:
0.0		 3fbxA-1jvbA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 8 GLY A 216
ALA A 217
ASP A 218
ILE A 190
 None
 0.66A 3so9A-1jvbA:
undetectable		 3so9A-1jvbA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 120
LEU A  13
ASP A  41
ILE A   9
ILE A  54
 None
 0.89A 3tq9A-1jvbA:
4.2		 3tq9A-1jvbA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 THR A 153
LEU A 118
GLY A 119
VAL A  32
ILE A  30
 None
 0.97A 4c9lA-1jvbA:
undetectable		 4c9lA-1jvbA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 THR A 153
LEU A 118
GLY A 119
VAL A  32
ILE A  30
 None
 0.94A 4c9lB-1jvbA:
undetectable		 4c9lB-1jvbA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 10 ALA A  91
ILE A  30
VAL A 130
ALA A  35
ALA A  34
 None
 1.03A 4lbgA-1jvbA:
3.7		 4lbgA-1jvbA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 ALA A  91
ILE A  30
VAL A 130
ALA A  35
ALA A  34
 None
 1.08A 4lbgB-1jvbA:
3.9		 4lbgB-1jvbA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 9 VAL A 344
VAL A   4
ALA A   3
VAL A  32
ALA A  35
 None
 1.24A 4oqrA-1jvbA:
undetectable		 4oqrA-1jvbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		3 / 3 ARG A  45
GLN A  46
GLU A 335
 None
 0.92A 4tvtA-1jvbA:
0.0		 4tvtA-1jvbA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 6 THR A 253
VAL A 256
TYR A 257
VAL A 204
 None
 0.68A 5eckA-1jvbA:
undetectable		 5eckA-1jvbA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 6 THR A 253
VAL A 256
TYR A 257
VAL A 204
 None
 0.69A 5eckD-1jvbA:
0.0		 5eckD-1jvbA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 6 THR A 253
VAL A 256
TYR A 257
VAL A 204
 None
 0.74A 5eclA-1jvbA:
0.0		 5eclA-1jvbA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		3 / 3 ALA A 330
ASN A 333
LEU A 334
 None
 0.32A 5i1nB-1jvbA:
0.0		 5i1nB-1jvbA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		3 / 3 ALA A 330
ASN A 333
LEU A 334
 None
 0.37A 5i1oA-1jvbA:
undetectable		 5i1oA-1jvbA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD2_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 4 GLY A  97
CYH A 112
ARG A 116
GLY A  99
 ZN  A 400 ( 4.6A)
ZN  A 400 ( 2.3A)
None
ZN  A 400 ( 4.8A)
 0.89A 5inzA-1jvbA:
undetectable
5inzC-1jvbA:
undetectable
5inzD-1jvbA:
undetectable		 5inzA-1jvbA:
7.04
5inzC-1jvbA:
7.04
5inzD-1jvbA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A  35
GLU A 329
ILE A 331
ARG A  45
VAL A   4
 None
 1.32A 5vlmE-1jvbA:
undetectable		 5vlmE-1jvbA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 5 GLY A 265
GLN A 290
VAL A 268
SER A 167
 None
 1.16A 5vunA-1jvbA:
0.0		 5vunA-1jvbA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		3 / 3 VAL A   4
TYR A 126
GLU A 325
 None
 0.97A 5zmqD-1jvbA:
0.0
5zmqE-1jvbA:
undetectable		 5zmqD-1jvbA:
22.19
5zmqE-1jvbA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Sulfolobus
solfataricus) 		3 / 3 GLY A 216
ASP A 218
ILE A 200
 None
 0.62A 6dgxB-1jvbA:
undetectable		 6dgxB-1jvbA:
12.42