SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jvw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 9 PHE A 114
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 1.05A 1bkfA-1jvwA:
15.1		 1bkfA-1jvwA:
41.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 9 TYR A  92
ASP A 103
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 0.56A 1bkfA-1jvwA:
15.1		 1bkfA-1jvwA:
41.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 9 TYR A  92
VAL A 119
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 0.43A 1bkfA-1jvwA:
15.1		 1bkfA-1jvwA:
41.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9H_A_RAPA108_1
(FKBP12.6)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 12 TYR A  92
ASP A 103
VAL A 119
ILE A 120
TYR A 146
ILE A 155
PHE A 163
 None
 0.59A 1c9hA-1jvwA:
14.9		 1c9hA-1jvwA:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9H_A_RAPA108_1
(FKBP12.6)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 12 TYR A  92
GLU A 118
VAL A 119
ILE A 120
TYR A 146
ILE A 155
PHE A 163
 None
 0.47A 1c9hA-1jvwA:
14.9		 1c9hA-1jvwA:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9H_A_RAPA108_1
(FKBP12.6)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 12 TYR A  92
PHE A 114
ILE A 120
TYR A 146
ILE A 155
PHE A 163
 None
 0.95A 1c9hA-1jvwA:
14.9		 1c9hA-1jvwA:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 12 TYR A  92
ASP A 103
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.58A 1fapA-1jvwA:
15.6		 1fapA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 12 TYR A  92
GLU A 118
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.54A 1fapA-1jvwA:
15.6		 1fapA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 12 TYR A  92
GLU A 118
VAL A 119
TRP A 123
ILE A 155
PHE A 163
 None
 1.13A 1fapA-1jvwA:
15.6		 1fapA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 12 TYR A  92
PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.93A 1fapA-1jvwA:
15.6		 1fapA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 12 PHE A 114
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 1.02A 1fkbA-1jvwA:
15.5		 1fkbA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 12 TYR A  92
ASP A 103
VAL A 119
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 0.64A 1fkbA-1jvwA:
15.5		 1fkbA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 12 TYR A  92
GLU A 118
VAL A 119
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 0.46A 1fkbA-1jvwA:
15.5		 1fkbA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 12 TYR A  92
GLU A 118
VAL A 119
TRP A 123
ILE A 155
 None
 1.17A 1fkbA-1jvwA:
15.5		 1fkbA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 11 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.00A 1fkfA-1jvwA:
15.3		 1fkfA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.43A 1fkfA-1jvwA:
15.3		 1fkfA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.56A 1fkfA-1jvwA:
15.3		 1fkfA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 11 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.01A 1fkjA-1jvwA:
15.3		 1fkjA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.44A 1fkjA-1jvwA:
15.3		 1fkjA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.59A 1fkjA-1jvwA:
15.3		 1fkjA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 12 TYR A  92
ASP A 103
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.64A 1fklA-1jvwA:
15.3		 1fklA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 12 TYR A  92
GLU A 118
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.44A 1fklA-1jvwA:
15.3		 1fklA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 12 TYR A  92
PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.90A 1fklA-1jvwA:
15.3		 1fklA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PBK_A_RAPA225_1
(FKBP25)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 12 TYR A  92
ASP A 103
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.67A 1pbkA-1jvwA:
14.9		 1pbkA-1jvwA:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PBK_A_RAPA225_1
(FKBP25)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 12 TYR A  92
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.45A 1pbkA-1jvwA:
14.9		 1pbkA-1jvwA:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 9 TYR A  92
ASP A 103
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.63A 1q6iA-1jvwA:
20.6		 1q6iA-1jvwA:
31.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		9 / 10 TYR A  92
ASP A 103
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.69A 1q6iB-1jvwA:
20.6		 1q6iB-1jvwA:
31.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 PHE A 114
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.96A 1tcoC-1jvwA:
15.2		 1tcoC-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.46A 1tcoC-1jvwA:
15.2		 1tcoC-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.76A 1tcoC-1jvwA:
15.2		 1tcoC-1jvwA:
42.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		3 / 3 LEU A 144
LEU A 138
MET A  52
 None
 0.70A 1ya3B-1jvwA:
undetectable		 1ya3B-1jvwA:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 11 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.97A 1yatA-1jvwA:
16.8		 1yatA-1jvwA:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.46A 1yatA-1jvwA:
16.8		 1yatA-1jvwA:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.62A 1yatA-1jvwA:
16.8		 1yatA-1jvwA:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
ASP A 103
VAL A 119
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 0.58A 2dg3A-1jvwA:
15.5		 2dg3A-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
GLU A 118
VAL A 119
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 0.42A 2dg3A-1jvwA:
15.5		 2dg3A-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 11 TYR A  92
PHE A 114
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 0.94A 2dg3A-1jvwA:
15.5		 2dg3A-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 11 TYR A  92
ASP A 103
VAL A 119
ILE A 120
TYR A 146
PHE A 163
 None
 0.63A 2dg4A-1jvwA:
15.0		 2dg4A-1jvwA:
41.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 11 TYR A  92
GLU A 118
VAL A 119
ILE A 120
TYR A 146
PHE A 163
 None
 0.37A 2dg4A-1jvwA:
15.0		 2dg4A-1jvwA:
41.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 11 TYR A  92
PHE A 114
ILE A 120
TYR A 146
PHE A 163
 None
 1.01A 2dg4A-1jvwA:
15.0		 2dg4A-1jvwA:
41.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
ASP A 103
GLU A 118
VAL A 119
ILE A 120
TYR A 146
PHE A 163
 None
 0.71A 2dg9A-1jvwA:
15.2		 2dg9A-1jvwA:
41.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 11 TYR A  92
PHE A 114
ILE A 120
TYR A 146
PHE A 163
 None
 0.99A 2dg9A-1jvwA:
15.2		 2dg9A-1jvwA:
41.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 11 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.01A 2fkeA-1jvwA:
15.5		 2fkeA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.43A 2fkeA-1jvwA:
15.5		 2fkeA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.59A 2fkeA-1jvwA:
15.5		 2fkeA-1jvwA:
42.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		4 / 6 ALA A 189
ASP A 192
GLU A 190
ARG A  72
 None
 0.99A 2ouzA-1jvwA:
undetectable		 2ouzA-1jvwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		4 / 6 LEU A 144
TRP A 136
MET A 130
LEU A 127
 None
 1.27A 2oz7A-1jvwA:
undetectable		 2oz7A-1jvwA:
19.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 11 TYR A  92
PHE A 102
ASP A 103
ILE A 120
TRP A 123
TYR A 146
 None
 1.02A 2vcdA-1jvwA:
18.4		 2vcdA-1jvwA:
40.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 11 TYR A  92
PHE A 102
PHE A 114
ILE A 120
TRP A 123
TYR A 146
 None
 0.98A 2vcdA-1jvwA:
18.4		 2vcdA-1jvwA:
40.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 11 TYR A  92
PHE A 114
VAL A 119
ILE A 120
TRP A 123
TYR A 146
 None
 0.78A 2vcdA-1jvwA:
18.4		 2vcdA-1jvwA:
40.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 11 PHE A 102
PHE A 114
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.09A 2vn1A-1jvwA:
15.8		 2vn1A-1jvwA:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
PHE A 102
ARG A 108
VAL A 119
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.63A 2vn1A-1jvwA:
15.8		 2vn1A-1jvwA:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
PHE A 102
ASP A 103
ARG A 108
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.78A 2vn1A-1jvwA:
15.8		 2vn1A-1jvwA:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_B_FK5B501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 10 PHE A 114
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 1.04A 2vn1B-1jvwA:
15.8		 2vn1B-1jvwA:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_B_FK5B501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 10 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 0.47A 2vn1B-1jvwA:
15.8		 2vn1B-1jvwA:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_B_FK5B501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 10 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 0.79A 2vn1B-1jvwA:
15.8		 2vn1B-1jvwA:
28.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 10 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.99A 3ihzA-1jvwA:
15.7		 3ihzA-1jvwA:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 10 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.46A 3ihzA-1jvwA:
15.7		 3ihzA-1jvwA:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 10 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.56A 3ihzA-1jvwA:
15.7		 3ihzA-1jvwA:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 8 PHE A 114
TRP A 123
TYR A 146
GLY A 152
ILE A 155
 None
 1.35A 3ihzB-1jvwA:
16.2		 3ihzB-1jvwA:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 8 PHE A 114
TRP A 123
TYR A 146
GLY A 153
ILE A 155
 None
 1.08A 3ihzB-1jvwA:
16.2		 3ihzB-1jvwA:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 8 TYR A  92
ASP A 103
TRP A 123
TYR A 146
GLY A 153
ILE A 155
 None
 0.47A 3ihzB-1jvwA:
16.2		 3ihzB-1jvwA:
36.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 10 TYR A  92
ASP A 103
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.60A 3kz7A-1jvwA:
14.9		 3kz7A-1jvwA:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 10 TYR A  92
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.42A 3kz7A-1jvwA:
14.9		 3kz7A-1jvwA:
29.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 PHE A 114
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.01A 3o5rA-1jvwA:
16.4		 3o5rA-1jvwA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.45A 3o5rA-1jvwA:
16.4		 3o5rA-1jvwA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.66A 3o5rA-1jvwA:
16.4		 3o5rA-1jvwA:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 10 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.00A 3uf8A-1jvwA:
16.8		 3uf8A-1jvwA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 10 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.49A 3uf8A-1jvwA:
16.8		 3uf8A-1jvwA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 10 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.64A 3uf8A-1jvwA:
16.8		 3uf8A-1jvwA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 10 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.01A 3uqaA-1jvwA:
16.8		 3uqaA-1jvwA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 10 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.52A 3uqaA-1jvwA:
16.8		 3uqaA-1jvwA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 10 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.72A 3uqaA-1jvwA:
16.8		 3uqaA-1jvwA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 8 PHE A 114
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.07A 3uqbA-1jvwA:
16.6		 3uqbA-1jvwA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 8 TYR A  92
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.43A 3uqbA-1jvwA:
16.6		 3uqbA-1jvwA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 11 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.01A 3vawA-1jvwA:
16.2		 3vawA-1jvwA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.45A 3vawA-1jvwA:
16.2		 3vawA-1jvwA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.67A 3vawA-1jvwA:
16.2		 3vawA-1jvwA:
27.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 12 TYR A  92
ASP A 103
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.65A 4drhA-1jvwA:
15.5		 4drhA-1jvwA:
30.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 12 TYR A  92
PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.94A 4drhA-1jvwA:
15.5		 4drhA-1jvwA:
30.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 12 TYR A  92
ASP A 103
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.61A 4drhD-1jvwA:
15.6		 4drhD-1jvwA:
30.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 12 TYR A  92
PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.95A 4drhD-1jvwA:
15.6		 4drhD-1jvwA:
30.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.70A 4driA-1jvwA:
16.4		 4driA-1jvwA:
30.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.98A 4driA-1jvwA:
16.4		 4driA-1jvwA:
30.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.90A 4driA-1jvwA:
16.4		 4driA-1jvwA:
30.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 GLU A 118
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.43A 4drjA-1jvwA:
16.1		 4drjA-1jvwA:
32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
ASP A 103
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.62A 4drjA-1jvwA:
16.1		 4drjA-1jvwA:
32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.91A 4drjA-1jvwA:
16.1		 4drjA-1jvwA:
32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.36A 4drjA-1jvwA:
16.1		 4drjA-1jvwA:
32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 ARG A 108
PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.03A 4dz2A-1jvwA:
16.7
4dz2B-1jvwA:
16.7		 4dz2A-1jvwA:
32.54
4dz2B-1jvwA:
32.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.61A 4dz2A-1jvwA:
16.7
4dz2B-1jvwA:
16.7		 4dz2A-1jvwA:
32.54
4dz2B-1jvwA:
32.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.73A 4dz2A-1jvwA:
16.7
4dz2B-1jvwA:
16.7		 4dz2A-1jvwA:
32.54
4dz2B-1jvwA:
32.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 ARG A 108
PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.02A 4dz2A-1jvwA:
16.7
4dz2B-1jvwA:
16.7		 4dz2A-1jvwA:
32.54
4dz2B-1jvwA:
32.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.57A 4dz2A-1jvwA:
16.7
4dz2B-1jvwA:
16.7		 4dz2A-1jvwA:
32.54
4dz2B-1jvwA:
32.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.70A 4dz2A-1jvwA:
16.7
4dz2B-1jvwA:
16.7		 4dz2A-1jvwA:
32.54
4dz2B-1jvwA:
32.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 10 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.99A 4dz3A-1jvwA:
16.7		 4dz3A-1jvwA:
32.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 10 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.51A 4dz3A-1jvwA:
16.7		 4dz3A-1jvwA:
32.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 10 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.68A 4dz3A-1jvwA:
16.7		 4dz3A-1jvwA:
32.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 10 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.00A 4dz3B-1jvwA:
16.7		 4dz3B-1jvwA:
32.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 10 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.43A 4dz3B-1jvwA:
16.7		 4dz3B-1jvwA:
32.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 10 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.63A 4dz3B-1jvwA:
16.7		 4dz3B-1jvwA:
32.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 10 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.99A 4laxA-1jvwA:
16.3		 4laxA-1jvwA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 10 TYR A  92
ASP A 103
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.67A 4laxA-1jvwA:
16.3		 4laxA-1jvwA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 10 TYR A  92
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.42A 4laxA-1jvwA:
16.3		 4laxA-1jvwA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		4 / 8 PHE A 102
SER A 159
ALA A 145
TYR A 146
 None
 0.94A 4lv9A-1jvwA:
0.0
4lv9B-1jvwA:
undetectable		 4lv9A-1jvwA:
13.10
4lv9B-1jvwA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		4 / 7 TYR A 146
PHE A 102
SER A 159
ALA A 145
 None
 0.94A 4lv9A-1jvwA:
undetectable
4lv9B-1jvwA:
undetectable		 4lv9A-1jvwA:
13.10
4lv9B-1jvwA:
13.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 12 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.99A 4nnrA-1jvwA:
12.6
4nnrB-1jvwA:
12.4		 4nnrA-1jvwA:
32.12
4nnrB-1jvwA:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 12 TYR A  92
ASP A 103
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.64A 4nnrA-1jvwA:
12.6
4nnrB-1jvwA:
12.4		 4nnrA-1jvwA:
32.12
4nnrB-1jvwA:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 12 TYR A  92
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.44A 4nnrA-1jvwA:
12.6
4nnrB-1jvwA:
12.4		 4nnrA-1jvwA:
32.12
4nnrB-1jvwA:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 10 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.01A 4nnrB-1jvwA:
12.4		 4nnrB-1jvwA:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 10 TYR A  92
ASP A 103
ILE A 120
TYR A 146
ILE A 155
PHE A 163
 None
 0.68A 4nnrB-1jvwA:
12.4		 4nnrB-1jvwA:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 10 TYR A  92
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.49A 4nnrB-1jvwA:
12.4		 4nnrB-1jvwA:
32.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 10 TYR A  92
ASP A 103
ILE A 120
TYR A 146
PHE A 163
 None
 0.72A 4odoA-1jvwA:
8.8		 4odoA-1jvwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 10 TYR A  92
ASP A 103
ILE A 120
TYR A 146
PHE A 163
 None
 0.69A 4odoB-1jvwA:
8.5		 4odoB-1jvwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 10 TYR A  92
ASP A 103
ILE A 120
TYR A 146
PHE A 163
 None
 0.70A 4odoC-1jvwA:
8.4		 4odoC-1jvwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 12 TYR A  92
ASP A 103
ILE A 120
TYR A 146
ILE A 155
PHE A 163
 None
 0.76A 4odrA-1jvwA:
9.9
4odrB-1jvwA:
9.9		 4odrA-1jvwA:
26.88
4odrB-1jvwA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 11 TYR A  92
ASP A 103
ILE A 120
TYR A 146
PHE A 163
 None
 0.69A 4odrA-1jvwA:
9.9
4odrB-1jvwA:
9.9		 4odrA-1jvwA:
26.88
4odrB-1jvwA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 10 TYR A  92
ASP A 103
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.62A 4qt2A-1jvwA:
16.0		 4qt2A-1jvwA:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 10 TYR A  92
GLU A 118
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.46A 4qt2A-1jvwA:
16.0		 4qt2A-1jvwA:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 10 TYR A  92
PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.90A 4qt2A-1jvwA:
16.0		 4qt2A-1jvwA:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 10 TYR A  92
ASP A 103
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.61A 4qt3A-1jvwA:
14.9		 4qt3A-1jvwA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 10 TYR A  92
GLU A 118
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.45A 4qt3A-1jvwA:
14.9		 4qt3A-1jvwA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 10 TYR A  92
PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.91A 4qt3A-1jvwA:
14.9		 4qt3A-1jvwA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		3 / 3 LEU A 129
ARG A  72
ARG A 131
 None
 0.90A 4yiaB-1jvwA:
0.0		 4yiaB-1jvwA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 12 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.02A 5b8iC-1jvwA:
14.8		 5b8iC-1jvwA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 12 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.65A 5b8iC-1jvwA:
14.8		 5b8iC-1jvwA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 12 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.81A 5b8iC-1jvwA:
14.8		 5b8iC-1jvwA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
ASP A 103
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.52A 5d75A-1jvwA:
15.0		 5d75A-1jvwA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.42A 5d75A-1jvwA:
15.0		 5d75A-1jvwA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 12 ILE A  84
GLY A 176
ARG A 177
GLU A  89
LEU A 127
 None
 1.07A 5fhzD-1jvwA:
undetectable		 5fhzD-1jvwA:
16.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
ASP A 103
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.59A 5gpgA-1jvwA:
15.8		 5gpgA-1jvwA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.37A 5gpgA-1jvwA:
15.8		 5gpgA-1jvwA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 12 TYR A  92
ASP A 103
VAL A 119
ILE A 120
TYR A 146
ILE A 155
PHE A 163
 None
 0.65A 5hkgA-1jvwA:
15.0		 5hkgA-1jvwA:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 12 TYR A  92
GLU A 118
VAL A 119
ILE A 120
TYR A 146
ILE A 155
PHE A 163
 None
 0.47A 5hkgA-1jvwA:
15.0		 5hkgA-1jvwA:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 12 TYR A  92
PHE A 114
ILE A 120
TYR A 146
ILE A 155
PHE A 163
 None
 0.96A 5hkgA-1jvwA:
15.0		 5hkgA-1jvwA:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 11 PHE A 114
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 1.04A 5huaA-1jvwA:
16.9		 5huaA-1jvwA:
32.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 0.40A 5huaA-1jvwA:
16.9		 5huaA-1jvwA:
32.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 0.65A 5huaA-1jvwA:
16.9		 5huaA-1jvwA:
32.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 11 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
 None
 1.13A 5hw8A-1jvwA:
14.7
5hw8D-1jvwA:
14.7		 5hw8A-1jvwA:
32.47
5hw8D-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
 None
 0.73A 5hw8A-1jvwA:
14.7
5hw8D-1jvwA:
14.7		 5hw8A-1jvwA:
32.47
5hw8D-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
 None
 0.79A 5hw8A-1jvwA:
14.7
5hw8D-1jvwA:
14.7		 5hw8A-1jvwA:
32.47
5hw8D-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 11 PHE A 114
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.10A 5hw8B-1jvwA:
15.0		 5hw8B-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
ARG A 108
VAL A 119
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.66A 5hw8B-1jvwA:
15.0		 5hw8B-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
ASP A 103
ARG A 108
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.70A 5hw8B-1jvwA:
15.0		 5hw8B-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		9 / 10 TYR A  92
ASP A 103
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
LEU A 161
PHE A 163
 None
 0.72A 5hw8C-1jvwA:
14.8
5hw8H-1jvwA:
12.2		 5hw8C-1jvwA:
32.47
5hw8H-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 11 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.05A 5hw8D-1jvwA:
14.7		 5hw8D-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.65A 5hw8D-1jvwA:
14.7		 5hw8D-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.74A 5hw8D-1jvwA:
14.7		 5hw8D-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 11 ARG A 108
PHE A 114
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 1.01A 5hw8E-1jvwA:
14.5		 5hw8E-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 0.50A 5hw8E-1jvwA:
14.5		 5hw8E-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 11 TYR A  92
ASP A 103
ARG A 108
TYR A 146
PHE A 163
 None
 0.76A 5hw8E-1jvwA:
14.5		 5hw8E-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 12 PHE A 114
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 1.06A 5hw8B-1jvwA:
15.0
5hw8F-1jvwA:
11.8
5hw8G-1jvwA:
14.3		 5hw8B-1jvwA:
32.47
5hw8F-1jvwA:
32.47
5hw8G-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 12 TYR A  92
ASP A 103
ILE A 120
TYR A 146
PHE A 163
 None
 0.77A 5hw8B-1jvwA:
15.0
5hw8F-1jvwA:
11.8
5hw8G-1jvwA:
14.3		 5hw8B-1jvwA:
32.47
5hw8F-1jvwA:
32.47
5hw8G-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 12 TYR A  92
VAL A 119
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 0.46A 5hw8B-1jvwA:
15.0
5hw8F-1jvwA:
11.8
5hw8G-1jvwA:
14.3		 5hw8B-1jvwA:
32.47
5hw8F-1jvwA:
32.47
5hw8G-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 11 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.00A 5hw8G-1jvwA:
14.3		 5hw8G-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
ASP A 103
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.61A 5hw8G-1jvwA:
14.3		 5hw8G-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		7 / 11 TYR A  92
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.56A 5hw8G-1jvwA:
14.3		 5hw8G-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		4 / 8 TYR A  92
ASP A 103
TRP A 123
PHE A 163
 None
 0.77A 5hw8H-1jvwA:
12.2		 5hw8H-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		5 / 8 TYR A  92
VAL A 119
ILE A 120
TRP A 123
PHE A 163
 None
 0.71A 5hw8H-1jvwA:
12.2		 5hw8H-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 11 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.99A 5hwcA-1jvwA:
15.8		 5hwcA-1jvwA:
32.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.56A 5hwcA-1jvwA:
15.8		 5hwcA-1jvwA:
32.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 11 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.61A 5hwcA-1jvwA:
15.8		 5hwcA-1jvwA:
32.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOC_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		4 / 6 TRP A 123
PHE A 139
VAL A 165
ARG A  95
 None
 1.22A 5uocA-1jvwA:
0.0
5uocB-1jvwA:
0.4		 5uocA-1jvwA:
18.81
5uocB-1jvwA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		3 / 3 LEU A 129
ALA A 126
LEU A 186
 None
 0.52A 5uunB-1jvwA:
undetectable		 5uunB-1jvwA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 12 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.99A 6mkeA-1jvwA:
16.3
6mkeD-1jvwA:
16.1		 6mkeA-1jvwA:
21.56
6mkeD-1jvwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 12 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.59A 6mkeA-1jvwA:
16.3
6mkeD-1jvwA:
16.1		 6mkeA-1jvwA:
21.56
6mkeD-1jvwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 12 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.75A 6mkeA-1jvwA:
16.3
6mkeD-1jvwA:
16.1		 6mkeA-1jvwA:
21.56
6mkeD-1jvwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 12 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.02A 6mkeB-1jvwA:
16.2
6mkeC-1jvwA:
16.2		 6mkeB-1jvwA:
21.56
6mkeC-1jvwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 12 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.52A 6mkeB-1jvwA:
16.2
6mkeC-1jvwA:
16.2		 6mkeB-1jvwA:
21.56
6mkeC-1jvwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		8 / 12 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.67A 6mkeB-1jvwA:
16.2
6mkeC-1jvwA:
16.2		 6mkeB-1jvwA:
21.56
6mkeC-1jvwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 10 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.96A 6mkeC-1jvwA:
16.2		 6mkeC-1jvwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		9 / 10 TYR A  92
ASP A 103
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.62A 6mkeC-1jvwA:
16.2		 6mkeC-1jvwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		6 / 10 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.96A 6mkeD-1jvwA:
16.1		 6mkeD-1jvwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR
(Trypanosoma
cruzi) 		9 / 10 TYR A  92
ASP A 103
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.62A 6mkeD-1jvwA:
16.1		 6mkeD-1jvwA:
21.56