SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jwa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN
(Escherichia
coli) 		5 / 12 LEU B  58
LEU B  94
ALA B  51
ILE B 161
ILE B  36
 None
 1.11A 1crbA-1jwaB:
0.1		 1crbA-1jwaB:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN
(Escherichia
coli) 		4 / 7 LEU B  60
LEU B  42
GLY B  40
LEU B  76
 None
None
ATP  B 250 (-3.4A)
None
 0.70A 1gtiA-1jwaB:
undetectable		 1gtiA-1jwaB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN
(Escherichia
coli) 		4 / 8 TYR B 215
THR B 165
PRO B 148
LEU B 124
 None
 1.16A 2v0zO-1jwaB:
undetectable		 2v0zO-1jwaB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN
(Escherichia
coli) 		5 / 12 GLU B   3
ALA B   2
GLU B  27
PHE B  23
ASP B  22
 None
 1.17A 3nmuA-1jwaB:
undetectable
3nmuF-1jwaB:
5.8		 3nmuA-1jwaB:
21.32
3nmuF-1jwaB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN
(Escherichia
coli) 		5 / 12 GLU B   3
ALA B   2
GLU B  27
PHE B  23
ASP B  22
 None
 1.06A 3nvkF-1jwaB:
0.1
3nvkJ-1jwaB:
6.0		 3nvkF-1jwaB:
21.16
3nvkJ-1jwaB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN
(Escherichia
coli) 		5 / 8 LEU B  58
VAL B  34
ILE B 209
ALA B  53
LEU B  29
 None
 1.44A 4qrcA-1jwaB:
undetectable		 4qrcA-1jwaB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN
(Escherichia
coli) 		5 / 11 ILE B 200
GLY B 152
ALA B 154
LEU B 196
VAL B 192
 None
 1.23A 5hw4B-1jwaB:
2.2		 5hw4B-1jwaB:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN
(Escherichia
coli) 		3 / 3 THR B  81
SER B  89
ASP B  64
 None
None
ATP  B 250 (-4.5A)
 0.70A 5kvaA-1jwaB:
6.2		 5kvaA-1jwaB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN
(Escherichia
coli) 		5 / 10 ALA B  46
ILE B 103
ILE B 101
VAL B  55
ALA B 205
 None
 1.22A 5nukA-1jwaB:
undetectable		 5nukA-1jwaB:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN
(Escherichia
coli) 		5 / 7 GLY B  41
LEU B  42
ILE B 200
GLY B 198
ILE B 209
 ATP  B 250 (-3.6A)
None
None
None
None
 1.32A 5vkqA-1jwaB:
undetectable
5vkqB-1jwaB:
undetectable		 5vkqA-1jwaB:
9.38
5vkqB-1jwaB:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN
(Escherichia
coli) 		5 / 7 LEU B  42
LEU B 124
ILE B 200
GLY B 198
ILE B 209
 None
 1.35A 5vkqA-1jwaB:
undetectable
5vkqB-1jwaB:
undetectable		 5vkqA-1jwaB:
9.38
5vkqB-1jwaB:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN
(Escherichia
coli) 		4 / 5 VAL B 106
THR B 104
LEU B 110
LEU B 138
 None
 1.02A 6bqgA-1jwaB:
undetectable		 6bqgA-1jwaB:
12.50