SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jxi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		4 / 5 THR A 205
THR A 214
HIS A 261
HIS A 209
 None
None
None
SO4  A2005 (-4.3A)
 1.42A 1d4fA-1jxiA:
5.6		 1d4fA-1jxiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		3 / 3 ASP A  58
ASP A  65
ASP A  85
 None
 0.74A 1eizA-1jxiA:
3.5		 1eizA-1jxiA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		3 / 3 ASP A  58
ASP A  65
ASP A  85
 None
 0.76A 1ej0A-1jxiA:
3.4		 1ej0A-1jxiA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		4 / 5 LEU A 189
GLU A 193
ALA A 172
LEU A 174
 None
 0.90A 1eta2-1jxiA:
0.0		 1eta2-1jxiA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		5 / 10 GLY A  11
GLU A  44
GLY A  19
THR A  39
VAL A  42
 HMH  A2001 (-3.6A)
HMH  A2001 (-3.0A)
HMH  A2001 ( 3.8A)
None
None
 1.29A 1v3qE-1jxiA:
2.5		 1v3qE-1jxiA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		4 / 5 LEU A 244
THR A 205
THR A 214
HIS A 261
 None
 1.36A 2zj0C-1jxiA:
4.9		 2zj0C-1jxiA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		4 / 7 THR A 232
LEU A 189
LEU A 135
LEU A 174
 None
 0.83A 3bgdB-1jxiA:
0.8		 3bgdB-1jxiA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		4 / 6 LEU A   7
ILE A  20
ALA A  10
THR A  39
 None
 0.89A 3mdrA-1jxiA:
undetectable		 3mdrA-1jxiA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		5 / 10 ASP A  13
GLY A  17
ALA A  18
ILE A 256
VAL A  49
 None
None
HMH  A2001 ( 4.0A)
None
None
 1.09A 3nu9B-1jxiA:
undetectable		 3nu9B-1jxiA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		4 / 4 GLY A 212
GLY A 210
THR A 208
LEU A 244
 SO4  A2003 (-3.2A)
SO4  A2005 (-3.6A)
None
None
 0.79A 3si7C-1jxiA:
1.0
3si7D-1jxiA:
1.0		 3si7C-1jxiA:
20.38
3si7D-1jxiA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		4 / 5 LEU A 244
GLY A 212
GLY A 210
THR A 208
 None
SO4  A2003 (-3.2A)
SO4  A2005 (-3.6A)
None
 0.77A 3si7C-1jxiA:
0.7
3si7D-1jxiA:
1.0		 3si7C-1jxiA:
20.38
3si7D-1jxiA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		4 / 6 CYH A 213
THR A 214
GLY A  19
ASP A  23
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 3.8A)
None
 1.20A 3w9tE-1jxiA:
undetectable		 3w9tE-1jxiA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		4 / 7 THR A  26
TRP A 239
HIS A 263
LEU A 244
 None
 1.37A 4awuA-1jxiA:
3.6		 4awuA-1jxiA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		5 / 11 ALA A  18
VAL A  49
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 ( 4.0A)
None
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 1.26A 4c5lA-1jxiA:
32.2		 4c5lA-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		9 / 11 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 4.0A)
HMH  A2001 ( 3.8A)
None
HMH  A2001 ( 4.5A)
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 0.52A 4c5lA-1jxiA:
32.2		 4c5lA-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		5 / 9 ALA A  18
VAL A  49
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 ( 4.0A)
None
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 1.28A 4c5lB-1jxiA:
31.7		 4c5lB-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		9 / 9 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 4.0A)
HMH  A2001 ( 3.8A)
None
HMH  A2001 ( 4.5A)
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 0.52A 4c5lB-1jxiA:
31.7		 4c5lB-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		5 / 10 ALA A  18
VAL A  49
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 ( 4.0A)
None
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 1.22A 4c5lC-1jxiA:
32.0		 4c5lC-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		9 / 10 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 4.0A)
HMH  A2001 ( 3.8A)
None
HMH  A2001 ( 4.5A)
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 0.53A 4c5lC-1jxiA:
32.0		 4c5lC-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		5 / 10 ALA A  18
VAL A  49
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 ( 4.0A)
None
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 1.25A 4c5lD-1jxiA:
31.8		 4c5lD-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		9 / 10 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 4.0A)
HMH  A2001 ( 3.8A)
None
HMH  A2001 ( 4.5A)
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 0.53A 4c5lD-1jxiA:
31.8		 4c5lD-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		7 / 7 GLY A  11
ASP A  13
GLY A  19
VAL A  42
MET A  80
HIS A 209
CYH A 213
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 3.8A)
None
HMH  A2001 ( 4.5A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 0.55A 4c5nA-1jxiA:
31.5		 4c5nA-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		5 / 10 ALA A  18
VAL A  49
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 ( 4.0A)
None
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 1.23A 4c5nB-1jxiA:
31.9		 4c5nB-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		9 / 10 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 4.0A)
HMH  A2001 ( 3.8A)
None
HMH  A2001 ( 4.5A)
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 0.51A 4c5nB-1jxiA:
31.9		 4c5nB-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		8 / 8 GLY A  11
ASP A  13
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 3.8A)
None
HMH  A2001 ( 4.5A)
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 0.53A 4c5nC-1jxiA:
31.3		 4c5nC-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		9 / 10 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 4.0A)
HMH  A2001 ( 3.8A)
None
HMH  A2001 ( 4.5A)
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 0.54A 4c5nD-1jxiA:
31.8		 4c5nD-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		5 / 10 ASP A 105
GLY A  11
ILE A  38
VAL A  90
ILE A  78
 SO4  A2003 (-2.9A)
HMH  A2001 (-3.6A)
None
None
None
 1.10A 4dqcA-1jxiA:
undetectable		 4dqcA-1jxiA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		4 / 6 LYS A  77
ILE A   9
VAL A  90
LEU A  94
 None
 1.04A 4em2A-1jxiA:
0.0		 4em2A-1jxiA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		4 / 7 THR A  12
ILE A  38
THR A   8
GLY A  79
 None
 0.95A 4eqlB-1jxiA:
0.9		 4eqlB-1jxiA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		3 / 3 VAL A  60
LEU A  64
VAL A  37
 None
 0.42A 4wq4A-1jxiA:
undetectable		 4wq4A-1jxiA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		4 / 5 ASP A  13
VAL A 107
ASP A 105
GLY A 212
 None
HMH  A2001 ( 4.7A)
SO4  A2003 (-2.9A)
SO4  A2003 (-3.2A)
 1.09A 4xp6A-1jxiA:
0.0		 4xp6A-1jxiA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		6 / 12 VAL A 103
ALA A 220
LYS A  77
ALA A 236
ASP A 187
GLY A  19
 None
None
None
None
None
HMH  A2001 ( 3.8A)
 1.44A 5hesB-1jxiA:
undetectable		 5hesB-1jxiA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		5 / 12 ALA A  32
ALA A  82
ALA A  40
THR A  12
THR A  26
 None
 1.25A 5tl8A-1jxiA:
0.0		 5tl8A-1jxiA:
20.75