SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jxn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		4 / 5 GLY A 104
SER A 215
THR A  90
PHE A 107
 MFU  A 501 (-3.5A)
None
None
None
 1.22A 1icuC-1jxnA:
0.0
1icuD-1jxnA:
0.0		 1icuC-1jxnA:
21.84
1icuD-1jxnA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		4 / 5 GLY A 104
SER A 215
THR A  90
PHE A 107
 MFU  A 501 (-3.5A)
None
None
None
 1.34A 1icvA-1jxnA:
0.0
1icvB-1jxnA:
0.0		 1icvA-1jxnA:
21.84
1icvB-1jxnA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		4 / 5 GLY A 104
SER A 215
THR A  90
PHE A 107
 MFU  A 501 (-3.5A)
None
None
None
 1.32A 1icvC-1jxnA:
undetectable
1icvD-1jxnA:
undetectable		 1icvC-1jxnA:
21.84
1icvD-1jxnA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		5 / 12 LEU A  89
GLY A 163
TYR A 187
VAL A 167
ALA A 168
 None
 1.19A 2kceB-1jxnA:
0.0		 2kceB-1jxnA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		4 / 8 GLY A  46
THR A  45
GLY A 108
ALA A 103
 None
 0.73A 3aruA-1jxnA:
undetectable		 3aruA-1jxnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		5 / 9 ASP A  87
GLY A 221
ILE A 220
VAL A 133
ILE A 129
 MFU  A 501 (-3.1A)
None
None
None
None
 1.26A 3ekyB-1jxnA:
undetectable		 3ekyB-1jxnA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		5 / 12 PHE A  92
ASP A  87
PHE A 110
ASP A 137
SER A 152
 None
MFU  A 501 (-3.1A)
None
MN  A 245 ( 2.7A)
MN  A 245 ( 4.3A)
 1.22A 3ko0K-1jxnA:
undetectable
3ko0L-1jxnA:
undetectable
3ko0S-1jxnA:
undetectable
3ko0T-1jxnA:
undetectable		 3ko0K-1jxnA:
21.25
3ko0L-1jxnA:
21.25
3ko0S-1jxnA:
21.25
3ko0T-1jxnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		5 / 12 PHE A 107
GLY A  88
GLY A 108
SER A 215
ALA A  24
 None
 1.20A 3sueD-1jxnA:
undetectable		 3sueD-1jxnA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		4 / 8 SER A 193
SER A 195
SER A 184
THR A 186
 None
 0.77A 4ikjA-1jxnA:
undetectable
4ikjB-1jxnA:
undetectable		 4ikjA-1jxnA:
19.82
4ikjB-1jxnA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		4 / 8 SER A 184
THR A 186
SER A 193
SER A 195
 None
 0.83A 4ikkA-1jxnA:
undetectable
4ikkB-1jxnA:
undetectable		 4ikkA-1jxnA:
19.82
4ikkB-1jxnA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		4 / 8 SER A 193
SER A 195
SER A 184
THR A 186
 None
 0.73A 4iklA-1jxnA:
undetectable
4iklB-1jxnA:
undetectable		 4iklA-1jxnA:
19.82
4iklB-1jxnA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		4 / 6 ILE A 129
GLY A 105
VAL A 150
HIS A 142
 None
MFU  A 501 (-3.1A)
None
MN  A 245 (-3.8A)
 0.90A 4oltA-1jxnA:
0.0		 4oltA-1jxnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		4 / 6 ILE A 129
GLY A 105
VAL A 150
HIS A 142
 None
MFU  A 501 (-3.1A)
None
MN  A 245 (-3.8A)
 0.92A 4oltB-1jxnA:
undetectable		 4oltB-1jxnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		4 / 8 GLY A 130
SER A 152
ASN A 134
HIS A 142
 CA  A 246 ( 4.4A)
MN  A 245 ( 4.3A)
MFU  A 501 ( 3.0A)
MN  A 245 (-3.8A)
 1.04A 4wrzA-1jxnA:
undetectable		 4wrzA-1jxnA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		5 / 12 ALA A 123
LEU A 202
ILE A  57
VAL A 212
PHE A 233
 None
 1.31A 5vlmB-1jxnA:
undetectable		 5vlmB-1jxnA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		5 / 12 ALA A 123
LEU A 202
ILE A  57
VAL A 212
PHE A 233
 None
 1.25A 5vlmE-1jxnA:
undetectable		 5vlmE-1jxnA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		5 / 12 ALA A 123
LEU A 202
ILE A  57
VAL A 212
PHE A 233
 None
 1.24A 5vlmG-1jxnA:
undetectable		 5vlmG-1jxnA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		5 / 12 GLY A 216
GLY A  88
VAL A  37
GLY A  46
GLY A  47
 None
 0.95A 5wyqA-1jxnA:
undetectable		 5wyqA-1jxnA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		5 / 12 VAL A 124
ASP A 146
PHE A  68
ARG A  50
LEU A 206
 None
 1.20A 6ew0G-1jxnA:
undetectable		 6ew0G-1jxnA:
15.60