SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jy1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.89A 1cqeA-1jy1A:
undetectable		 1cqeA-1jy1A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.90A 1cqeB-1jy1A:
0.0		 1cqeB-1jy1A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 9 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.85A 1eqgA-1jy1A:
undetectable		 1eqgA-1jy1A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 11 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.86A 1eqgB-1jy1A:
undetectable		 1eqgB-1jy1A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.91A 1eqhA-1jy1A:
undetectable		 1eqhA-1jy1A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.93A 1eqhB-1jy1A:
undetectable		 1eqhB-1jy1A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 PHE A 416
LEU A 517
LEU A 439
 None
 0.60A 1mx1E-1jy1A:
undetectable		 1mx1E-1jy1A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 7 VAL A 227
TYR A 537
ALA A 332
LEU A 335
 None
 0.81A 1pthA-1jy1A:
undetectable		 1pthA-1jy1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 7 VAL A 227
TYR A 537
ALA A 332
LEU A 335
 None
 0.81A 1pthB-1jy1A:
undetectable		 1pthB-1jy1A:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RFF_B_SPMB700_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 4 ASN A 591
ASN A 603
TRP A 605
PRO A 607
 None
 0.25A 1rffB-1jy1A:
65.5		 1rffB-1jy1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RFI_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1
TOPOISOMERASE
I-DERIVED PEPTIDE)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 5 TRP A 590
TRP A 605
VAL A 606
PRO A 607
 None
 0.30A 1rfiA-1jy1A:
66.2
1rfiC-1jy1A:
undetectable		 1rfiA-1jy1A:
100.00
1rfiC-1jy1A:
9.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 TRP A 605
VAL A 606
PRO A 607
 None
 0.22A 1rg1A-1jy1A:
66.1		 1rg1A-1jy1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG2_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 5 TRP A 590
ASN A 591
TRP A 605
VAL A 606
PRO A 607
 None
 0.32A 1rg2A-1jy1A:
66.3		 1rg2A-1jy1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RGU_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 5 TRP A 590
ASN A 591
TRP A 605
VAL A 606
PRO A 607
 None
 0.29A 1rguA-1jy1A:
66.2		 1rguA-1jy1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 TRP A 605
VAL A 606
PRO A 607
 None
 0.22A 1rh0A-1jy1A:
66.2		 1rh0A-1jy1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 LEU A 275
LEU A 270
SER A 198
 None
 0.56A 1tlmA-1jy1A:
0.0		 1tlmA-1jy1A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 HIS A 478
LEU A 576
VAL A 555
MET A 498
LEU A 437
 None
 1.48A 2prgB-1jy1A:
0.0		 2prgB-1jy1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 LEU A 539
GLY A 356
GLY A 371
LEU A 354
LEU A 323
 None
 1.08A 2zbpA-1jy1A:
undetectable		 2zbpA-1jy1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 4 VAL A 171
ASP A 187
LEU A 298
ARG A 487
 None
 1.39A 2ziaA-1jy1A:
undetectable		 2ziaA-1jy1A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 TYR A 497
TYR A 574
ILE A 440
 None
 0.71A 3eteA-1jy1A:
0.3
3eteB-1jy1A:
undetectable		 3eteA-1jy1A:
21.83
3eteB-1jy1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 6 LEU A 298
SER A 299
LEU A 301
LEU A 158
 None
 1.05A 3f33A-1jy1A:
undetectable		 3f33A-1jy1A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.99A 3ln1A-1jy1A:
0.0		 3ln1A-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.97A 3ln1B-1jy1A:
undetectable		 3ln1B-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.98A 3ln1C-1jy1A:
undetectable		 3ln1C-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.80A 3n8wA-1jy1A:
0.0		 3n8wA-1jy1A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.82A 3n8zA-1jy1A:
undetectable		 3n8zA-1jy1A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.82A 3n8zB-1jy1A:
0.0		 3n8zB-1jy1A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.81A 3nt1A-1jy1A:
0.0		 3nt1A-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.83A 3nt1B-1jy1A:
0.0		 3nt1B-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.89A 3rr3A-1jy1A:
0.0		 3rr3A-1jy1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.90A 3rr3B-1jy1A:
undetectable		 3rr3B-1jy1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 7 HIS A 280
ASP A 288
TRP A 289
HIS A 493
 None
 0.99A 3zodA-1jy1A:
0.0		 3zodA-1jy1A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 302
ILE A 188
LEU A 268
VAL A 278
ILE A 296
 None
 1.11A 4aztA-1jy1A:
2.0		 4aztA-1jy1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.89A 4coxA-1jy1A:
undetectable		 4coxA-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.89A 4coxC-1jy1A:
undetectable		 4coxC-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 ASP A 187
ARG A 170
ASP A 156
 None
 0.81A 4fp9A-1jy1A:
undetectable		 4fp9A-1jy1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 8 GLY A 371
THR A 513
LEU A 542
ARG A 374
 None
 0.94A 4m5mA-1jy1A:
undetectable		 4m5mA-1jy1A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 HIS A 478
LEU A 576
VAL A 555
MET A 498
LEU A 437
 None
 1.46A 4o8fB-1jy1A:
0.0		 4o8fB-1jy1A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 1.01A 4otyA-1jy1A:
0.0		 4otyA-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.96A 4otyB-1jy1A:
0.0		 4otyB-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 10 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.88A 4ph9A-1jy1A:
undetectable		 4ph9A-1jy1A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 10 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.87A 4ph9B-1jy1A:
undetectable		 4ph9B-1jy1A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.95A 4rrwA-1jy1A:
0.0		 4rrwA-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.92A 4rrwB-1jy1A:
0.0		 4rrwB-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.93A 4rrwC-1jy1A:
0.0		 4rrwC-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.94A 4rrwD-1jy1A:
0.0		 4rrwD-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.95A 4rrzA-1jy1A:
0.0		 4rrzA-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.92A 4rrzB-1jy1A:
0.0		 4rrzB-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.93A 4rrzC-1jy1A:
0.0		 4rrzC-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.94A 4rrzD-1jy1A:
0.0		 4rrzD-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 302
ILE A 188
LEU A 268
VAL A 278
ILE A 296
 None
 1.08A 4uw0A-1jy1A:
undetectable		 4uw0A-1jy1A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 11 LEU A 439
TYR A 476
LEU A 517
LEU A 404
LEU A 412
 None
 1.07A 4wg0I-1jy1A:
undetectable
4wg0J-1jy1A:
undetectable
4wg0K-1jy1A:
undetectable		 4wg0I-1jy1A:
2.94
4wg0J-1jy1A:
2.94
4wg0K-1jy1A:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 11 LEU A 439
TYR A 476
LEU A 517
LEU A 404
LEU A 412
 None
 1.06A 4wg0K-1jy1A:
undetectable
4wg0L-1jy1A:
undetectable
4wg0M-1jy1A:
undetectable		 4wg0K-1jy1A:
2.94
4wg0L-1jy1A:
2.94
4wg0M-1jy1A:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 1.01A 5ikqA-1jy1A:
0.0		 5ikqA-1jy1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 1.01A 5ikqB-1jy1A:
0.0		 5ikqB-1jy1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.98A 5ikrA-1jy1A:
0.0		 5ikrA-1jy1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.99A 5ikrB-1jy1A:
0.0		 5ikrB-1jy1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.93A 5jvzA-1jy1A:
0.0		 5jvzA-1jy1A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.93A 5kirA-1jy1A:
0.0		 5kirA-1jy1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.98A 5kirB-1jy1A:
undetectable		 5kirB-1jy1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1S_A_SAMA604_0
(RADICAL SAM)		 1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 9 SER A 403
GLN A 470
VAL A 401
TYR A 441
SER A 399
 None
 1.49A 5v1sA-1jy1A:
2.0		 5v1sA-1jy1A:
22.50