SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jye'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		4 / 5 ASP A 302
VAL A 301
SER A 300
GLN A  89
 None
 1.39A 1n2xB-1jyeA:
4.4		 1n2xB-1jyeA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		3 / 3 ILE A 123
ILE A  64
THR A  68
 None
 0.53A 1rg7A-1jyeA:
2.0		 1rg7A-1jyeA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		3 / 3 ILE A 289
ASP A 292
PHE A 293
 None
 0.50A 1uwjB-1jyeA:
undetectable		 1uwjB-1jyeA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		5 / 10 ILE A 124
ALA A  67
VAL A 119
PRO A 144
ILE A  64
 None
 1.01A 2nnjA-1jyeA:
undetectable		 2nnjA-1jyeA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		4 / 5 ALA A 256
ALA A 183
ALA A 214
GLN A 231
 None
 0.92A 2nyrB-1jyeA:
5.2		 2nyrB-1jyeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		4 / 4 THR A 229
VAL A 264
GLY A 272
THR A 288
 None
 1.02A 3cflA-1jyeA:
0.2		 3cflA-1jyeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		4 / 8 PHE A 293
LEU A  73
PRO A  76
TRP A 220
 None
None
None
GOL  A 350 ( 4.2A)
 1.21A 3jq7B-1jyeA:
7.0		 3jq7B-1jyeA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		3 / 3 SER A 191
ASP A 149
ASN A 125
 None
 0.92A 3lsfB-1jyeA:
2.4
3lsfE-1jyeA:
3.1		 3lsfB-1jyeA:
22.56
3lsfE-1jyeA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		3 / 3 ASP A 149
ASN A 125
SER A 191
 None
 0.92A 3lsfB-1jyeA:
2.4
3lsfE-1jyeA:
3.1		 3lsfB-1jyeA:
22.56
3lsfE-1jyeA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		3 / 3 ASP A 149
ASN A 125
SER A 193
 None
None
GOL  A 350 ( 4.3A)
 0.99A 3lsfB-1jyeA:
2.4
3lsfE-1jyeA:
3.1		 3lsfB-1jyeA:
22.56
3lsfE-1jyeA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		6 / 10 ALA A  87
ILE A  64
GLY A 297
ILE A  79
VAL A  96
VAL A  94
 None
 1.37A 4j5jB-1jyeA:
undetectable		 4j5jB-1jyeA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		4 / 6 VAL A  94
VAL A  66
ILE A 123
LEU A 305
 None
 0.90A 4l1wB-1jyeA:
undetectable		 4l1wB-1jyeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		5 / 7 VAL A  99
ALA A 106
LEU A 114
ASP A 149
LEU A 128
 None
 1.40A 4l9iA-1jyeA:
0.0		 4l9iA-1jyeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		5 / 12 ALA A  87
GLY A 121
GLY A  65
LEU A 114
GLU A 137
 None
 0.99A 4lg1A-1jyeA:
undetectable		 4lg1A-1jyeA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		5 / 12 ALA A  87
GLY A 121
GLY A  65
LEU A 114
GLU A 137
 None
 1.02A 4lg1B-1jyeA:
undetectable		 4lg1B-1jyeA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		3 / 3 VAL A 324
THR A 288
ARG A 326
 None
 0.77A 5b2sB-1jyeA:
undetectable		 5b2sB-1jyeA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		3 / 3 VAL A 324
THR A 288
ARG A 326
 None
 0.79A 5b2tB-1jyeA:
1.5		 5b2tB-1jyeA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		4 / 7 VAL A 244
LEU A 286
VAL A 264
THR A 328
 None
 1.03A 5e4dA-1jyeA:
undetectable
5e4dB-1jyeA:
0.0		 5e4dA-1jyeA:
20.57
5e4dB-1jyeA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		5 / 9 SER A 120
GLY A  65
ALA A  87
VAL A  94
ILE A 123
 None
 1.43A 5i3cA-1jyeA:
undetectable		 5i3cA-1jyeA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1jye LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		4 / 8 ASN A 125
GLN A 291
PRO A  76
ILE A  79
 None
GOL  A 350 (-3.4A)
None
None
 0.85A 6hzpA-1jyeA:
undetectable		 6hzpA-1jyeA:
22.83