SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jyh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 1jyh DNA GYRASE
INHIBITORY PROTEIN
(Escherichia
coli) 		3 / 3 ALA A  49
VAL A  69
TRP A  47
 None
 0.83A 1av2C-1jyhA:
undetectable
1av2D-1jyhA:
undetectable		 1av2C-1jyhA:
9.45
1av2D-1jyhA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 1jyh DNA GYRASE
INHIBITORY PROTEIN
(Escherichia
coli) 		3 / 3 ALA A  49
VAL A  69
TRP A  47
 None
 0.83A 1w5uC-1jyhA:
undetectable
1w5uD-1jyhA:
undetectable		 1w5uC-1jyhA:
9.45
1w5uD-1jyhA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1jyh DNA GYRASE
INHIBITORY PROTEIN
(Escherichia
coli) 		3 / 3 LEU A  33
TRP A  22
TYR A 134
 None
 0.97A 3aicG-1jyhA:
undetectable		 3aicG-1jyhA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1jyh DNA GYRASE
INHIBITORY PROTEIN
(Escherichia
coli) 		5 / 12 PHE A 131
ALA A  97
VAL A  48
GLU A   8
ILE A   5
 None
 1.21A 3dl9A-1jyhA:
undetectable		 3dl9A-1jyhA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 1jyh DNA GYRASE
INHIBITORY PROTEIN
(Escherichia
coli) 		4 / 6 ALA A 151
LEU A 126
MET A 125
LEU A 117
 None
 1.21A 4xp3A-1jyhA:
undetectable		 4xp3A-1jyhA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1jyh DNA GYRASE
INHIBITORY PROTEIN
(Escherichia
coli) 		4 / 6 ILE A  42
VAL A  84
TRP A  36
SER A  81
 None
 0.96A 5jwaH-1jyhA:
undetectable		 5jwaH-1jyhA:
14.01