SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jyl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 TRP A 165
VAL A 174
TRP A 191
 None
 1.29A 1c4dA-1jylA:
undetectable
1c4dB-1jylA:
undetectable		 1c4dA-1jylA:
5.73
1c4dB-1jylA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_A_RIOA500_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 9 ASP A 218
ASP A 107
GLY A  14
ASP A 192
ASP A 105
 MG  A1996 ( 2.8A)
MG  A1996 ( 2.4A)
CDC  A1991 (-3.4A)
CDC  A1991 (-3.3A)
CDC  A1991 ( 4.0A)
 1.29A 1m4gA-1jylA:
0.0		 1m4gA-1jylA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_B_RIOB501_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 9 ASP A 218
ASP A 107
GLY A  14
ASP A 192
ASP A 105
 MG  A1996 ( 2.8A)
MG  A1996 ( 2.4A)
CDC  A1991 (-3.4A)
CDC  A1991 (-3.3A)
CDC  A1991 ( 4.0A)
 1.31A 1m4gB-1jylA:
0.0		 1m4gB-1jylA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 8 ASP A 218
ASP A 107
GLY A  14
ASP A 192
ASP A 105
 MG  A1996 ( 2.8A)
MG  A1996 ( 2.4A)
CDC  A1991 (-3.4A)
CDC  A1991 (-3.3A)
CDC  A1991 ( 4.0A)
 1.39A 1m4iA-1jylA:
0.0		 1m4iA-1jylA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 ASP A 197
ASN A 198
THR A 169
 None
 0.78A 2q63B-1jylA:
undetectable		 2q63B-1jylA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 TYR A 109
GLU A  44
ILE A  43
PHE A  65
ILE A  10
 None
 1.24A 3ndiA-1jylA:
2.2		 3ndiA-1jylA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A  30
ALA A 106
ASP A 105
ASN A 108
ILE A  54
 None
CDC  A1991 (-3.6A)
CDC  A1991 ( 4.0A)
None
None
 1.03A 3ucbA-1jylA:
undetectable		 3ucbA-1jylA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 VAL A 162
GLY A 161
TYR A 124
ASP A 192
 None
None
None
CDC  A1991 (-3.3A)
 1.30A 3w9tA-1jylA:
undetectable		 3w9tA-1jylA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 VAL A 162
GLY A 161
TYR A 124
ASP A 192
 None
None
None
CDC  A1991 (-3.3A)
 1.30A 3w9tB-1jylA:
undetectable		 3w9tB-1jylA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 VAL A 162
GLY A 161
TYR A 124
ASP A 192
 None
None
None
CDC  A1991 (-3.3A)
 1.30A 3w9tC-1jylA:
undetectable		 3w9tC-1jylA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 VAL A 162
GLY A 161
TYR A 124
ASP A 192
 None
None
None
CDC  A1991 (-3.3A)
 1.30A 3w9tD-1jylA:
undetectable		 3w9tD-1jylA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 VAL A 162
GLY A 161
TYR A 124
ASP A 192
 None
None
None
CDC  A1991 (-3.3A)
 1.30A 3w9tE-1jylA:
undetectable		 3w9tE-1jylA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 VAL A 162
GLY A 161
TYR A 124
ASP A 192
 None
None
None
CDC  A1991 (-3.3A)
 1.30A 3w9tF-1jylA:
undetectable		 3w9tF-1jylA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 VAL A 162
GLY A 161
TYR A 124
ASP A 192
 None
None
None
CDC  A1991 (-3.3A)
 1.29A 3w9tG-1jylA:
undetectable		 3w9tG-1jylA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 8 GLN A  42
ILE A  10
PHE A 115
GLY A 161
GLU A 216
 None
None
None
None
MG  A1996 ( 2.6A)
 1.50A 4fgjA-1jylA:
undetectable
4fgjB-1jylA:
undetectable		 4fgjA-1jylA:
21.53
4fgjB-1jylA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A  76
LEU A  68
ILE A  10
ALA A 106
ILE A  43
 None
None
None
CDC  A1991 (-3.6A)
None
 1.01A 5eypB-1jylA:
undetectable		 5eypB-1jylA:
20.36