SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 1jyo PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica) 		4 / 6 LEU E  53
LEU E  80
PRO E  57
VAL E  65
 None
 1.03A 2dqyC-1jyoE:
undetectable		 2dqyC-1jyoE:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 1jyo SICP
(Salmonella
enterica) 		5 / 12 LEU A  48
ILE A   7
LEU A 100
ILE A  11
PHE A  21
 None
 1.25A 2gj5A-1jyoA:
0.1		 2gj5A-1jyoA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1jyo SICP
(Salmonella
enterica) 		4 / 7 TYR A  84
TRP A  64
VAL A  58
ILE A  63
 None
 1.26A 2xz5B-1jyoA:
undetectable
2xz5E-1jyoA:
undetectable		 2xz5B-1jyoA:
20.47
2xz5E-1jyoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1jyo SICP
(Salmonella
enterica) 		4 / 8 ILE A  63
TYR A  84
TRP A  64
VAL A  58
 None
 1.26A 2xz5A-1jyoA:
0.1
2xz5C-1jyoA:
undetectable		 2xz5A-1jyoA:
20.47
2xz5C-1jyoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1jyo SICP
(Salmonella
enterica) 		4 / 8 ILE A  63
TYR A  84
TRP A  64
VAL A  58
 None
 1.29A 2xz5C-1jyoA:
undetectable
2xz5D-1jyoA:
undetectable		 2xz5C-1jyoA:
20.47
2xz5D-1jyoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1jyo SICP
(Salmonella
enterica) 		4 / 7 ILE A  63
TYR A  84
TRP A  64
VAL A  58
 None
 1.26A 2xz5D-1jyoA:
undetectable
2xz5E-1jyoA:
undetectable		 2xz5D-1jyoA:
20.47
2xz5E-1jyoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1jyo SICP
(Salmonella
enterica) 		4 / 8 TYR A  84
TRP A  64
VAL A  58
ILE A  63
 None
 1.24A 4bqtC-1jyoA:
undetectable
4bqtD-1jyoA:
undetectable		 4bqtC-1jyoA:
20.47
4bqtD-1jyoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 1jyo PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica) 		4 / 7 THR E  51
GLY E  54
ALA E  38
ILE E  72
 None
 0.86A 4txnA-1jyoE:
undetectable		 4txnA-1jyoE:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 1jyo PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica) 		4 / 7 THR E  51
GLY E  54
ALA E  38
ILE E  72
 None
 0.88A 4txnB-1jyoE:
undetectable		 4txnB-1jyoE:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 1jyo PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica) 		4 / 7 THR E  51
GLY E  54
ALA E  38
ILE E  72
 None
 0.90A 4txnC-1jyoE:
undetectable		 4txnC-1jyoE:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 1jyo PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica) 		4 / 7 THR E  51
GLY E  54
ALA E  38
ILE E  72
 None
 0.89A 4txnD-1jyoE:
undetectable		 4txnD-1jyoE:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 1jyo SICP
PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica;
Salmonella
enterica) 		6 / 12 ILE E 134
SER E 136
LEU A  30
GLY E 129
ILE A  85
LEU A  92
 None
 1.34A 6dwnC-1jyoE:
undetectable		 6dwnC-1jyoE:
23.36