SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k0f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		5 / 12 HIS A 133
HIS A  68
GLU A 248
ASP A 279
ASP A  66
 None
 1.23A 1a4lA-1k0fA:
undetectable		 1a4lA-1k0fA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		5 / 12 HIS A 133
HIS A  68
GLU A 248
ASP A 279
ASP A  66
 None
 1.24A 1a4lC-1k0fA:
undetectable		 1a4lC-1k0fA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		5 / 12 HIS A  68
GLY A 218
GLU A 248
ASP A 279
ASP A  66
 None
 1.15A 1a4lD-1k0fA:
undetectable		 1a4lD-1k0fA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		4 / 7 LEU A 140
TYR A 204
TRP A 135
ASN A  89
 None
 1.25A 1afsA-1k0fA:
0.4		 1afsA-1k0fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		4 / 7 LEU A 140
TYR A 204
TRP A 135
ASN A  89
 None
 1.25A 1afsB-1k0fA:
0.3		 1afsB-1k0fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		5 / 8 ASP A  66
THR A 221
ASP A 279
HIS A 133
HIS A 199
 None
 1.42A 1ei6C-1k0fA:
undetectable		 1ei6C-1k0fA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		4 / 8 PHE A 236
LEU A 242
ILE A 272
ILE A 245
 None
 0.95A 1sbrA-1k0fA:
undetectable		 1sbrA-1k0fA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		5 / 12 TYR A 204
ALA A  46
VAL A 113
ALA A 112
LEU A  91
 None
 1.20A 1udtA-1k0fA:
undetectable		 1udtA-1k0fA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		3 / 3 ILE A 251
ASP A 200
PHE A 202
 None
 0.64A 1uwjB-1k0fA:
0.0		 1uwjB-1k0fA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		3 / 3 GLN A 171
LYS A 146
VAL A 148
 None
 0.89A 2jfaB-1k0fA:
0.0		 2jfaB-1k0fA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		5 / 12 ALA A 201
TRP A 135
LEU A 123
LEU A  91
THR A  95
 None
 1.43A 2oaxC-1k0fA:
undetectable		 2oaxC-1k0fA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		5 / 12 ALA A 201
TRP A 135
LEU A 123
LEU A  91
THR A  95
 None
 1.43A 2oaxF-1k0fA:
undetectable		 2oaxF-1k0fA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		5 / 12 HIS A  68
GLY A 218
SER A 278
ASP A 279
ASP A  66
 None
 1.10A 2pgfA-1k0fA:
undetectable		 2pgfA-1k0fA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		4 / 4 GLY A 293
GLU A 288
ASP A 300
TYR A 180
 None
 0.87A 2yvlC-1k0fA:
undetectable		 2yvlC-1k0fA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		5 / 12 SER A 206
VAL A 219
HIS A  68
LEU A  93
LEU A  69
 None
 1.36A 2zlcA-1k0fA:
0.0		 2zlcA-1k0fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		5 / 12 ALA A 198
GLU A 248
LEU A  93
VAL A 219
THR A 197
 None
 1.07A 3ix9A-1k0fA:
undetectable		 3ix9A-1k0fA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		5 / 12 LEU A  60
LEU A  57
ILE A  86
GLY A  81
ALA A  83
 None
 1.11A 3n8xB-1k0fA:
0.0		 3n8xB-1k0fA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		3 / 3 HIS A 133
HIS A  68
HIS A 199
 None
 0.50A 3qpkA-1k0fA:
undetectable		 3qpkA-1k0fA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		3 / 3 HIS A 133
HIS A  68
HIS A 199
 None
 0.49A 3qpkB-1k0fA:
undetectable		 3qpkB-1k0fA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		3 / 3 LYS A  33
PRO A  34
LEU A  35
 None
 0.84A 3tpxE-1k0fA:
undetectable		 3tpxE-1k0fA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		4 / 6 HIS A 133
GLU A 248
ASP A 279
SER A 250
 None
 0.95A 4apjA-1k0fA:
undetectable
4apjP-1k0fA:
undetectable		 4apjA-1k0fA:
19.38
4apjP-1k0fA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		5 / 12 ARG A 266
ILE A 245
LEU A 259
ALA A 235
LEU A 242
 None
 1.00A 4m11B-1k0fA:
0.1		 4m11B-1k0fA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		5 / 12 SER A 250
HIS A 199
ILE A 251
HIS A  68
LEU A  93
 None
 1.24A 4xumA-1k0fA:
0.0		 4xumA-1k0fA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		4 / 5 LEU A 216
ARG A 260
ILE A 245
ILE A 272
 None
 1.05A 5dzk4-1k0fA:
undetectable
5dzkg-1k0fA:
undetectable
5dzkm-1k0fA:
undetectable
5dzkn-1k0fA:
undetectable		 5dzk4-1k0fA:
1.60
5dzkg-1k0fA:
21.30
5dzkm-1k0fA:
20.85
5dzkn-1k0fA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		4 / 4 ILE A 245
ILE A 272
ARG A 260
LEU A 216
 None
 1.33A 5dzkh-1k0fA:
0.0
5dzkn-1k0fA:
undetectable
5dzkv-1k0fA:
undetectable		 5dzkh-1k0fA:
20.85
5dzkn-1k0fA:
20.85
5dzkv-1k0fA:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		3 / 3 HIS A 133
HIS A  68
HIS A 199
 None
 0.49A 5migA-1k0fA:
undetectable		 5migA-1k0fA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		4 / 5 THR A 197
HIS A 199
ASP A 279
HIS A 133
 None
 1.44A 6dchA-1k0fA:
undetectable		 6dchA-1k0fA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA
(Treponema
pallidum) 		4 / 5 VAL A  36
PHE A 277
MET A 294
GLY A 293
 None
 1.42A 6hd4A-1k0fA:
undetectable		 6hd4A-1k0fA:
13.45