SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k0g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		5 / 10 GLU A 258
ARG A 410
GLY A 426
GLU A 439
LYS A 443
 None
 1.06A 1i7qC-1k0gA:
37.3		 1i7qC-1k0gA:
31.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		3 / 3 PHE A 218
TYR A 437
TYR A 193
 None
 0.97A 1x70B-1k0gA:
0.0		 1x70B-1k0gA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		5 / 11 GLU A 258
ARG A 410
GLY A 426
GLU A 439
LYS A 443
 None
 1.04A 2fn1A-1k0gA:
36.9		 2fn1A-1k0gA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		5 / 11 GLU A 258
ARG A 410
GLY A 426
GLU A 439
LYS A 443
 None
 1.05A 2fn1B-1k0gA:
36.6		 2fn1B-1k0gA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		3 / 3 TRP A 184
GLN A 450
TRP A 390
 None
 1.39A 2vqyA-1k0gA:
0.0		 2vqyA-1k0gA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		4 / 5 ILE A 409
SER A 256
PRO A 257
PHE A 241
 None
None
None
TRP  A 601 (-3.9A)
 1.27A 3bjwC-1k0gA:
0.0		 3bjwC-1k0gA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		5 / 12 LEU A 114
ALA A 135
GLY A  61
LEU A  57
ARG A  72
 None
 1.07A 3gyqA-1k0gA:
undetectable
3gyqB-1k0gA:
undetectable		 3gyqA-1k0gA:
21.05
3gyqB-1k0gA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		3 / 3 GLU A  19
LEU A 231
LEU A 412
 None
 0.70A 3ohtA-1k0gA:
undetectable		 3ohtA-1k0gA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		5 / 12 ILE A 268
MET A 403
ASN A 402
ILE A  48
ALA A 354
 None
 1.12A 3ohtA-1k0gA:
undetectable
3ohtB-1k0gA:
0.0		 3ohtA-1k0gA:
21.52
3ohtB-1k0gA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		3 / 3 GLU A  19
LEU A 231
LEU A 412
 None
 0.67A 3ohtB-1k0gA:
undetectable		 3ohtB-1k0gA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		4 / 6 ILE A 144
ASN A  97
PRO A   6
LEU A 155
 None
 1.12A 3oi8A-1k0gA:
undetectable		 3oi8A-1k0gA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		5 / 12 ARG A 359
PHE A 118
THR A  75
VAL A  82
LEU A  83
 None
 1.27A 3s79A-1k0gA:
0.0		 3s79A-1k0gA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		5 / 12 PHE A 118
SER A 406
ILE A 394
THR A  59
ALA A 361
 None
TRP  A 601 ( 4.1A)
None
None
None
 1.15A 3ua1A-1k0gA:
0.0		 3ua1A-1k0gA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		4 / 8 ILE A 344
ILE A 261
LEU A 357
ILE A 268
 None
 0.90A 4dtaB-1k0gA:
undetectable		 4dtaB-1k0gA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		5 / 12 VAL A 136
PHE A 362
PHE A 110
PHE A 260
THR A  59
 None
 1.22A 4eckA-1k0gA:
undetectable		 4eckA-1k0gA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		4 / 8 PHE A 260
ILE A 367
GLY A 115
GLU A 119
 None
 0.77A 4fgjA-1k0gA:
undetectable
4fgjB-1k0gA:
undetectable		 4fgjA-1k0gA:
19.43
4fgjB-1k0gA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		4 / 4 LEU A  25
SER A  23
LEU A  33
LEU A 167
 None
 1.06A 4n09A-1k0gA:
undetectable		 4n09A-1k0gA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		3 / 3 ASP A 208
ARG A 374
TYR A 203
 None
 1.05A 5a7mA-1k0gA:
undetectable		 5a7mA-1k0gA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		5 / 8 LEU A 358
ILE A 314
PHE A 260
GLY A 365
THR A 368
 None
 1.40A 5eseA-1k0gA:
undetectable		 5eseA-1k0gA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		4 / 8 GLU A 119
GLY A 364
PRO A 363
ASP A 313
 None
 1.11A 5kf8A-1k0gA:
0.0		 5kf8A-1k0gA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		5 / 12 LEU A 109
ILE A 394
GLY A 395
LEU A 247
LEU A  34
 None
None
TRP  A 601 ( 4.1A)
None
TRP  A 601 (-3.6A)
 0.92A 5nfjA-1k0gA:
undetectable		 5nfjA-1k0gA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		3 / 3 HIS A 147
ASP A  47
HIS A  35
 None
 0.63A 5oexA-1k0gA:
0.0		 5oexA-1k0gA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		3 / 3 HIS A 147
ASP A  47
HIS A  35
 None
 0.65A 5oexB-1k0gA:
0.0		 5oexB-1k0gA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		3 / 3 HIS A 147
ASP A  47
HIS A  35
 None
 0.65A 5oexC-1k0gA:
0.0		 5oexC-1k0gA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		3 / 3 HIS A 147
ASP A  47
HIS A  35
 None
 0.62A 5oexD-1k0gA:
0.0		 5oexD-1k0gA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		6 / 11 ILE A 379
ILE A 427
GLY A 425
GLY A 424
LEU A 382
VAL A 200
 PO4  A 701 (-4.8A)
None
None
None
None
None
 1.31A 5twjD-1k0gA:
undetectable		 5twjD-1k0gA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		4 / 8 ALA A 346
VAL A 323
THR A 343
GLY A 315
 None
 0.96A 5v0vA-1k0gA:
undetectable		 5v0vA-1k0gA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		4 / 7 LEU A 247
LEU A 131
ALA A 389
THR A 408
 None
 0.88A 6a7jA-1k0gA:
undetectable		 6a7jA-1k0gA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		4 / 6 ILE A 419
GLN A 418
ILE A 129
ASP A 128
 None
 1.20A 6cbdA-1k0gA:
0.0		 6cbdA-1k0gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I
(Escherichia
coli) 		4 / 5 TYR A 193
GLN A 216
GLY A 369
ILE A 427
 None
 1.24A 6debB-1k0gA:
undetectable		 6debB-1k0gA:
10.74