SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 1k0k PROFILIN
(Saccharomyces
cerevisiae) 		4 / 4 GLY A  79
LEU A  70
GLY A  85
ARG A  80
 None
 1.06A 1j7kA-1k0kA:
0.0		 1j7kA-1k0kA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1k0k PROFILIN
(Saccharomyces
cerevisiae) 		4 / 8 ASN A  58
LEU A  55
GLY A  48
GLY A  43
 None
 0.87A 1rukH-1k0kA:
undetectable
1rukL-1k0kA:
undetectable		 1rukH-1k0kA:
18.39
1rukL-1k0kA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1k0k PROFILIN
(Saccharomyces
cerevisiae) 		4 / 8 GLN A  63
LEU A  37
VAL A  86
VAL A  28
 None
 1.00A 2bdmA-1k0kA:
0.1		 2bdmA-1k0kA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1469_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1k0k PROFILIN
(Saccharomyces
cerevisiae) 		4 / 4 GLN A  63
GLU A  41
LEU A  37
SER A  36
 None
 1.17A 2xrzA-1k0kA:
0.0		 2xrzA-1k0kA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 1k0k PROFILIN
(Saccharomyces
cerevisiae) 		4 / 4 LEU A  35
ILE A  77
TYR A 100
TYR A  21
 None
 1.44A 3vt7A-1k0kA:
undetectable		 3vt7A-1k0kA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1k0k PROFILIN
(Saccharomyces
cerevisiae) 		4 / 5 ILE A  45
LYS A  17
HIS A  99
VAL A  86
 None
 1.08A 5jmnB-1k0kA:
0.1		 5jmnB-1k0kA:
9.57