SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 1k12 LECTIN
(Anguilla
anguilla) 		4 / 8 GLU A 118
LEU A 145
ALA A  90
THR A 135
 None
 0.64A 1ie4B-1k12A:
undetectable
1ie4D-1k12A:
undetectable		 1ie4B-1k12A:
19.88
1ie4D-1k12A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1k12 LECTIN
(Anguilla
anguilla) 		3 / 3 TYR A  46
HIS A  52
ARG A  79
 None
FUC  A 159 (-3.8A)
FUC  A 159 (-2.7A)
 1.10A 4htfA-1k12A:
undetectable		 4htfA-1k12A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 1k12 LECTIN
(Anguilla
anguilla) 		3 / 3 TYR A 136
PRO A  59
LEU A 143
 None
 0.81A 6beoA-1k12A:
undetectable		 6beoA-1k12A:
10.45