SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k1d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		4 / 8 ASN A 186
THR A 211
ASP A 200
ASP A 191
 None
 0.99A 1bu5B-1k1dA:
undetectable		 1bu5B-1k1dA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  32
VAL A  50
ILE A   5
THR A  12
ILE A  10
 None
 0.93A 1c6zB-1k1dA:
undetectable		 1c6zB-1k1dA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		4 / 5 HIS A  58
HIS A 183
HIS A 239
ASP A 315
 ZN  A 502 (-3.5A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.7A)
ZN  A 502 (-3.0A)
 0.43A 1e9yB-1k1dA:
23.1		 1e9yB-1k1dA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 6 HIS A  58
HIS A  60
HIS A 183
HIS A 239
ASP A 315
 ZN  A 502 (-3.5A)
ZN  A 502 (-3.5A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.7A)
ZN  A 502 (-3.0A)
 0.63A 1fweC-1k1dA:
23.9		 1fweC-1k1dA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 10 PRO A  57
LEU A 375
PHE A 376
THR A 311
GLY A 261
 None
 1.01A 1h4oA-1k1dA:
0.2
1h4oB-1k1dA:
1.0		 1h4oA-1k1dA:
16.81
1h4oB-1k1dA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A 262
HIS A 239
HIS A 208
HIS A 183
TYR A 155
 None
ZN  A 501 (-3.7A)
None
ZN  A 501 (-3.3A)
None
 1.43A 1o86A-1k1dA:
undetectable		 1o86A-1k1dA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 11 ILE A  31
VAL A 386
THR A  12
ILE A 385
THR A 384
 None
 1.28A 1pkvA-1k1dA:
undetectable
1pkvB-1k1dA:
undetectable		 1pkvA-1k1dA:
14.35
1pkvB-1k1dA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		4 / 7 GLY A 323
ASP A 414
TYR A 415
PRO A 340
 None
 1.19A 1th6A-1k1dA:
undetectable		 1th6A-1k1dA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		4 / 7 GLY A 323
ASP A 414
TYR A 415
PRO A 340
 None
 1.19A 2armA-1k1dA:
undetectable		 2armA-1k1dA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 11 ASP A 315
HIS A  58
GLU A 185
HIS A 239
HIS A 208
 ZN  A 502 (-3.0A)
ZN  A 502 (-3.5A)
None
ZN  A 501 (-3.7A)
None
 1.21A 2q0jB-1k1dA:
undetectable		 2q0jB-1k1dA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 12 ASN A 337
ILE A 372
ASP A  56
PHE A  92
HIS A 123
 None
None
None
KCX  A 150 ( 3.7A)
None
 1.42A 2qmjA-1k1dA:
2.6		 2qmjA-1k1dA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A 342
GLN A 266
ASP A 344
GLY A  84
 None
 0.91A 2qqcH-1k1dA:
undetectable
2qqcK-1k1dA:
0.0		 2qqcH-1k1dA:
15.27
2qqcK-1k1dA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 8 LEU A 349
ILE A 359
LEU A 304
THR A 263
LEU A 312
 None
 1.26A 2xfhA-1k1dA:
undetectable		 2xfhA-1k1dA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 8 PHE A  74
GLY A  77
GLU A 343
ILE A 118
ALA A 116
 None
 1.43A 3aodA-1k1dA:
undetectable		 3aodA-1k1dA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 10 ILE A 341
GLY A  85
PHE A 396
VAL A 423
LEU A 312
 None
 1.35A 3elzB-1k1dA:
0.0		 3elzB-1k1dA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		4 / 6 GLN A 226
GLU A 229
LYS A 255
LEU A 257
 None
 0.83A 3h5gA-1k1dA:
undetectable
3h5gC-1k1dA:
undetectable		 3h5gA-1k1dA:
5.00
3h5gC-1k1dA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLN A 451
GLY A 448
GLY A 450
PHE A  74
ASN A 113
 None
 1.14A 3kkzA-1k1dA:
undetectable		 3kkzA-1k1dA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 12 PHE A 376
SER A 148
THR A 147
ILE A  89
LEU A 124
 None
 1.24A 3lcvB-1k1dA:
undetectable		 3lcvB-1k1dA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		3 / 3 SER A 127
PHE A 159
LYS A 151
 None
None
KCX  A 150 ( 3.7A)
 0.86A 3u88A-1k1dA:
undetectable		 3u88A-1k1dA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		4 / 6 GLU A 419
ASP A 344
ASP A 414
GLU A 343
 None
 1.34A 3vywA-1k1dA:
undetectable		 3vywA-1k1dA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A 277
PRO A 278
LYS A 284
 None
 1.42A 4dv7L-1k1dA:
0.0		 4dv7L-1k1dA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 388
ASP A 390
ASP A 392
THR A  12
 None
 0.79A 4eyrB-1k1dA:
undetectable		 4eyrB-1k1dA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		4 / 5 HIS A  58
HIS A 183
HIS A 239
ASP A 315
 ZN  A 502 (-3.5A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.7A)
ZN  A 502 (-3.0A)
 0.43A 4h9mA-1k1dA:
25.0		 4h9mA-1k1dA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 12 CYH A  48
PRO A 398
GLY A   8
ILE A  10
LEU A 361
 None
 1.37A 4kosA-1k1dA:
0.0		 4kosA-1k1dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 12 CYH A  48
PRO A 398
GLY A   8
ILE A  10
LEU A 361
 None
 1.44A 4kotA-1k1dA:
0.0		 4kotA-1k1dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOY_A_CSCA214_1
(UNCHARACTERIZED
PROTEIN)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 11 CYH A  48
PRO A 398
GLY A   8
ILE A  10
LEU A 361
 None
 1.40A 4koyA-1k1dA:
0.0		 4koyA-1k1dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 10 ASP A 320
ASP A 414
THR A  68
GLN A 324
THR A  70
 None
 1.46A 4n9uA-1k1dA:
undetectable		 4n9uA-1k1dA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  32
VAL A  50
ILE A   5
THR A  12
ILE A  10
 None
 0.92A 4njvD-1k1dA:
undetectable		 4njvD-1k1dA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 6 HIS A  58
HIS A  60
HIS A 183
HIS A 239
ASP A 315
 ZN  A 502 (-3.5A)
ZN  A 502 (-3.5A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.7A)
ZN  A 502 (-3.0A)
 0.51A 4ubpC-1k1dA:
24.1		 4ubpC-1k1dA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		4 / 4 GLY A  84
LEU A  61
PHE A  74
ILE A  89
 None
 0.87A 4xv2A-1k1dA:
0.0		 4xv2A-1k1dA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 261
ILE A 118
GLY A  85
PHE A 376
THR A 263
 None
 1.14A 4zdyA-1k1dA:
0.0		 4zdyA-1k1dA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		4 / 7 SER A 233
ASP A 163
ARG A 223
GLU A 219
 None
 1.11A 5btfA-1k1dA:
undetectable
5btfC-1k1dA:
undetectable
5btfD-1k1dA:
undetectable		 5btfA-1k1dA:
20.79
5btfC-1k1dA:
20.79
5btfD-1k1dA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 261
ILE A 118
GLY A  85
PHE A 376
THR A 263
 None
 1.15A 5eskA-1k1dA:
undetectable		 5eskA-1k1dA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 261
ILE A 118
GLY A  85
PHE A 376
THR A 263
 None
 1.18A 5eslA-1k1dA:
undetectable		 5eslA-1k1dA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 307
GLN A 310
LEU A 349
LEU A 375
TYR A 236
 None
 1.13A 5ji0D-1k1dA:
0.0		 5ji0D-1k1dA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 118
GLY A 450
PHE A 443
ALA A  81
VAL A 430
 None
 1.24A 5n0xB-1k1dA:
undetectable		 5n0xB-1k1dA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 9 ILE A 335
GLY A 328
GLY A 330
LEU A 275
ALA A 283
 None
 0.95A 5o96A-1k1dA:
undetectable
5o96B-1k1dA:
undetectable		 5o96A-1k1dA:
21.55
5o96B-1k1dA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		4 / 6 ASP A 344
GLN A 266
GLU A 343
ALA A 412
 None
 1.19A 6djzB-1k1dA:
undetectable		 6djzB-1k1dA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1k1d D-HYDANTOINASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 361
VAL A 365
SER A 369
THR A 370
VAL A 394
 None
 1.46A 6drxA-1k1dA:
undetectable		 6drxA-1k1dA:
20.91