SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k1e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Haemophilus
influenzae) 		4 / 6 LEU A 156
VAL A  15
VAL A  54
ILE A 105
 None
 1.17A 2hyyB-1k1eA:
undetectable		 2hyyB-1k1eA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Haemophilus
influenzae) 		5 / 10 VAL A  18
GLY A  17
LEU A 139
SER A 140
ALA A 147
 None
CO  A 201 ( 4.4A)
None
None
None
 0.97A 2v3kA-1k1eA:
4.0		 2v3kA-1k1eA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Haemophilus
influenzae) 		4 / 6 LEU A 156
VAL A  15
VAL A  54
ILE A 105
 None
 1.20A 3k5vA-1k1eA:
undetectable		 3k5vA-1k1eA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Haemophilus
influenzae) 		4 / 6 LEU A 156
VAL A  15
VAL A  54
ILE A 105
 None
 1.22A 3k5vB-1k1eA:
undetectable		 3k5vB-1k1eA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Haemophilus
influenzae) 		4 / 6 VAL A  54
VAL A  15
ILE A  69
ARG A 149
 None
 1.07A 3ms9A-1k1eA:
undetectable		 3ms9A-1k1eA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Haemophilus
influenzae) 		4 / 6 VAL A  54
VAL A  15
ILE A  69
ARG A 149
 None
 1.07A 3mssA-1k1eA:
undetectable		 3mssA-1k1eA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Haemophilus
influenzae) 		4 / 6 VAL A  54
VAL A  15
ILE A  69
ARG A 149
 None
 1.04A 3mssC-1k1eA:
undetectable		 3mssC-1k1eA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Haemophilus
influenzae) 		4 / 6 VAL A  54
VAL A  15
ILE A  69
ARG A 149
 None
 0.94A 3pyyA-1k1eA:
undetectable		 3pyyA-1k1eA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Haemophilus
influenzae) 		4 / 8 GLY A  96
THR A 102
LEU A  91
PHE A  10
 None
 1.13A 4m5mA-1k1eA:
undetectable		 4m5mA-1k1eA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Haemophilus
influenzae) 		3 / 3 SER A 121
ALA A 123
VAL A 124
 None
 0.38A 4x20C-1k1eA:
undetectable		 4x20C-1k1eA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Haemophilus
influenzae) 		5 / 10 ASP A 111
ASP A  16
GLY A 106
ASP A  90
THR A  86
 CO  A 201 ( 4.3A)
None
None
GOL  A2502 (-4.2A)
None
 1.44A 6mn1A-1k1eA:
1.0		 6mn1A-1k1eA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Haemophilus
influenzae) 		5 / 10 ASP A 111
ASP A  16
GLY A 106
ASP A  90
THR A  86
 CO  A 201 ( 4.3A)
None
None
GOL  A2502 (-4.2A)
None
 1.49A 6mn1B-1k1eA:
1.0		 6mn1B-1k1eA:
23.40