SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k20'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
gordonii) 		5 / 10 LEU A 267
ALA A 219
ASP A 205
VAL A 221
ILE A 204
 None
None
GOL  A 710 (-3.6A)
GOL  A 710 (-4.2A)
GOL  A 710 ( 4.7A)
 1.15A 1d4sA-1k20A:
undetectable		 1d4sA-1k20A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_B_TOYB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
gordonii) 		5 / 9 ASP A  13
GLU A  46
ALA A 294
THR A 257
ASP A 205
 MN  A 701 (-2.2A)
GOL  A 710 ( 4.8A)
None
None
GOL  A 710 (-3.6A)
 1.42A 1m4dB-1k20A:
0.0		 1m4dB-1k20A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
gordonii) 		4 / 8 ILE A  62
SER A  64
LEU A   5
GLU A  36
 None
 0.97A 2cdqA-1k20A:
0.4		 2cdqA-1k20A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
gordonii) 		4 / 5 LEU A  40
ALA A  16
ILE A  17
SER A  20
 None
MN  A 701 ( 4.0A)
None
None
 0.98A 2othA-1k20A:
undetectable		 2othA-1k20A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
gordonii) 		5 / 12 PHE A 129
LEU A   5
ALA A  39
MET A 144
GLU A 139
 None
 1.28A 2v0mC-1k20A:
0.0		 2v0mC-1k20A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
gordonii) 		5 / 12 ALA A 243
ILE A 240
LEU A 254
VAL A 221
ILE A 204
 None
None
None
GOL  A 710 (-4.2A)
GOL  A 710 ( 4.7A)
 0.98A 3adsB-1k20A:
0.0		 3adsB-1k20A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
gordonii) 		5 / 12 ALA A 243
ILE A 240
LEU A 254
VAL A 221
ILE A 204
 None
None
None
GOL  A 710 (-4.2A)
GOL  A 710 ( 4.7A)
 0.96A 3adxB-1k20A:
undetectable		 3adxB-1k20A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
gordonii) 		4 / 5 HIS A  99
HIS A 100
ASP A 151
ASP A  13
 MN  A 702 (-3.2A)
SO4  A 705 (-3.9A)
MN  A 702 (-2.8A)
MN  A 701 (-2.2A)
 1.03A 3c0zA-1k20A:
undetectable		 3c0zA-1k20A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
gordonii) 		4 / 6 HIS A  99
HIS A 100
ASP A 151
ASP A  13
 MN  A 702 (-3.2A)
SO4  A 705 (-3.9A)
MN  A 702 (-2.8A)
MN  A 701 (-2.2A)
 1.05A 3c0zC-1k20A:
undetectable		 3c0zC-1k20A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
gordonii) 		4 / 6 ALA A  58
ILE A  17
LEU A  51
GLU A  42
 None
 0.87A 3r9sA-1k20A:
undetectable		 3r9sA-1k20A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
gordonii) 		5 / 12 ALA A  70
VAL A  73
GLN A  10
ILE A  88
PHE A   7
 None
 1.23A 4c49A-1k20A:
undetectable		 4c49A-1k20A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
gordonii) 		5 / 12 ASP A 164
GLY A 119
ALA A 121
GLY A 147
ASP A  15
 None
None
MN  A 702 ( 4.6A)
None
MN  A 702 (-3.1A)
 0.91A 4dc3A-1k20A:
undetectable		 4dc3A-1k20A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
gordonii) 		4 / 7 LEU A  40
ALA A  16
ASP A  15
ILE A 140
 None
MN  A 701 ( 4.0A)
MN  A 702 (-3.1A)
None
 0.82A 4eyrA-1k20A:
undetectable		 4eyrA-1k20A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
gordonii) 		4 / 6 VAL A 229
LEU A 230
ARG A 232
LEU A 254
 None
 0.70A 4o1zA-1k20A:
undetectable		 4o1zA-1k20A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
gordonii) 		4 / 7 ASN A 178
GLU A 180
TYR A 182
GLU A 181
 None
 1.25A 4r87I-1k20A:
0.0		 4r87I-1k20A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
gordonii) 		5 / 12 PRO A  12
GLY A   8
ASP A 205
ILE A 204
ASP A  15
 None
None
GOL  A 710 (-3.6A)
GOL  A 710 ( 4.7A)
MN  A 702 (-3.1A)
 1.19A 5wwsB-1k20A:
undetectable		 5wwsB-1k20A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
gordonii) 		5 / 12 ILE A 140
VAL A  96
VAL A 125
LEU A  75
LEU A  40
 None
 1.33A 6a7pB-1k20A:
undetectable		 6a7pB-1k20A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
gordonii) 		5 / 12 ILE A 140
VAL A 125
LEU A  75
PHE A   7
LEU A  40
 None
 0.81A 6a7pB-1k20A:
undetectable		 6a7pB-1k20A:
21.23