SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k26'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 1k26 NUDIX HOMOLOG
(Pyrobaculum
aerophilum) 		5 / 12 LEU A   8
LEU A  15
VAL A  14
VAL A  98
LEU A  75
 None
 1.26A 3m7rA-1k26A:
0.0		 3m7rA-1k26A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFB_B_KANB401_1
(APH(2')-ID)		 1k26 NUDIX HOMOLOG
(Pyrobaculum
aerophilum) 		5 / 10 ASP A  93
SER A   5
GLU A  45
GLU A  49
GLU A  33
 GOL  A 209 (-4.2A)
GOL  A 209 ( 4.2A)
None
GOL  A 211 (-3.7A)
None
 1.19A 4dfbB-1k26A:
0.0		 4dfbB-1k26A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1k26 NUDIX HOMOLOG
(Pyrobaculum
aerophilum) 		5 / 8 GLY A   6
VAL A   7
ALA A 132
LEU A 136
GLY A  58
 None
 1.23A 4zauA-1k26A:
undetectable		 4zauA-1k26A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1k26 NUDIX HOMOLOG
(Pyrobaculum
aerophilum) 		4 / 5 TYR A  25
PHE A  46
LEU A 105
PRO A  28
 None
 1.44A 5csyB-1k26A:
undetectable		 5csyB-1k26A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1k26 NUDIX HOMOLOG
(Pyrobaculum
aerophilum) 		4 / 5 THR A   4
GLU A  49
THR A  50
LEU A   8
 None
GOL  A 211 (-3.7A)
None
None
 1.23A 5hm8G-1k26A:
undetectable		 5hm8G-1k26A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1k26 NUDIX HOMOLOG
(Pyrobaculum
aerophilum) 		4 / 5 PRO A  38
HIS A  31
TYR A  27
PHE A 122
 None
IR3  A 206 (-4.0A)
None
GOL  A 209 ( 4.8A)
 1.46A 5igjA-1k26A:
0.0		 5igjA-1k26A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1k26 NUDIX HOMOLOG
(Pyrobaculum
aerophilum) 		3 / 3 VAL A 128
ARG A  71
PRO A  56
 None
 0.85A 5koxA-1k26A:
undetectable		 5koxA-1k26A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 1k26 NUDIX HOMOLOG
(Pyrobaculum
aerophilum) 		4 / 5 GLU A  80
GLY A  30
SER A   5
GLY A   6
 GOL  A 209 (-3.1A)
GOL  A 209 (-3.7A)
GOL  A 209 ( 4.2A)
None
 1.11A 5kprA-1k26A:
undetectable		 5kprA-1k26A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1k26 NUDIX HOMOLOG
(Pyrobaculum
aerophilum) 		4 / 5 VAL A  14
PRO A  28
GLY A   6
TYR A  27
 None
 1.22A 5x80A-1k26A:
undetectable
5x80B-1k26A:
undetectable		 5x80A-1k26A:
22.73
5x80B-1k26A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1k26 NUDIX HOMOLOG
(Pyrobaculum
aerophilum) 		4 / 5 PRO A  28
GLY A   6
TYR A  27
VAL A  14
 None
 1.17A 5x80C-1k26A:
undetectable
5x80D-1k26A:
undetectable		 5x80C-1k26A:
22.73
5x80D-1k26A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 1k26 NUDIX HOMOLOG
(Pyrobaculum
aerophilum) 		5 / 10 ALA A 132
LEU A 133
VAL A   9
ILE A 111
THR A 121
 None
 1.35A 6h1lA-1k26A:
undetectable		 6h1lA-1k26A:
15.25