SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 GLY A  13
GLY A  85
LEU A  57
THR A  92
LEU A 251
 None
 1.04A 2nyuB-1k27A:
undetectable		 2nyuB-1k27A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 GLY A  13
GLY A  85
VAL A  91
THR A  92
LEU A 251
 None
 1.01A 2nyuB-1k27A:
undetectable		 2nyuB-1k27A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 LEU A 250
LEU A 251
ILE A 109
ALA A 216
THR A  93
 None
None
None
None
PO4  A 301 (-3.8A)
 1.08A 2v0mC-1k27A:
0.0		 2v0mC-1k27A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE
(Homo
sapiens) 		4 / 6 THR A 155
SER A 249
LEU A 250
THR A 253
 None
 0.94A 3deuB-1k27A:
undetectable		 3deuB-1k27A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE
(Homo
sapiens) 		4 / 7 ILE A  78
PHE A 144
TYR A 212
GLY A 209
 None
 0.85A 3em0B-1k27A:
undetectable		 3em0B-1k27A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE
(Homo
sapiens) 		3 / 3 MET A 196
MET A 185
PHE A 177
 MTM  A 401 (-3.7A)
None
MTM  A 401 (-4.8A)
 1.18A 3gn8A-1k27A:
undetectable		 3gn8A-1k27A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 VAL A 108
ILE A 114
GLY A 190
ALA A 191
LEU A  98
 None
 1.09A 3n8yB-1k27A:
0.0		 3n8yB-1k27A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE
(Homo
sapiens) 		4 / 8 ASP A 111
GLY A 167
PRO A 143
GLU A 142
 None
 1.01A 3s3mA-1k27A:
undetectable		 3s3mA-1k27A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE
(Homo
sapiens) 		4 / 8 TRP A 263
ILE A 210
GLY A  13
ILE A  12
 None
 0.86A 3wxoA-1k27A:
0.0		 3wxoA-1k27A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE
(Homo
sapiens) 		4 / 6 THR A 188
GLY A 190
ILE A 114
LEU A  98
 None
 1.23A 4ac9C-1k27A:
4.3		 4ac9C-1k27A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE
(Homo
sapiens) 		4 / 6 THR A 188
GLY A 190
ILE A 114
LEU A  98
 None
 1.19A 4acaC-1k27A:
4.0		 4acaC-1k27A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 GLY A 259
LEU A  26
GLY A  16
THR A  92
LEU A 251
 None
 1.03A 4ze2A-1k27A:
0.0		 4ze2A-1k27A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE
(Homo
sapiens) 		3 / 3 ARG A  60
TYR A 212
GLU A 201
 PO4  A 301 (-3.8A)
None
None
 0.47A 4zzbE-1k27A:
undetectable		 4zzbE-1k27A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE
(Homo
sapiens) 		3 / 3 TYR A  74
HIS A  61
MET A  68
 None
PO4  A 301 ( 3.8A)
None
 1.17A 6af6A-1k27A:
0.0		 6af6A-1k27A:
20.64